Results 31 to 40 of about 1,900,890 (167)
Role of transporters in regulating mammalian intracellular inorganic phosphate
Frontiers in Pharmacology, 2023 This review summarizes the current understanding of the role of plasma membrane transporters in regulating intracellular inorganic phosphate ([Pi]In) in mammals. Pi influx is mediated by SLC34 and SLC20 Na+-Pi cotransporters.
Michael L. Jennings
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Requirement of the Zinc-Binding Domain of ClpX for Spx Proteolysis inBacillus subtilisand Effects of Disulfide Stress on ClpXP Activity [PDF]
Journal of Bacteriology, 2007 ABSTRACTSpx, a transcriptional regulator of the disulfide stress response inBacillus subtilis, is under the proteolytic control of the ATP-dependent protease ClpXP. Previous studies suggested that ClpXP activity is down-regulated in response to disulfide stress, resulting in elevated concentrations of Spx.
Ying, Zhang, Peter, Zuber
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FEBS Letters, 2012 In the yeast Saccharomyces cerevisiae, a working model for nutrient homeostasis in eukaryotes, inorganic phosphate (Pi) homeostasis is regulated by the PHO pathway, a set of phosphate starvation induced genes, acting to optimize Pi uptake and utilization. Among these, a subset of proteins containing the SPX domain has been shown to be key regulators of
Secco, David. +3 more
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PLoS ONE, 2020 Galanin receptors (GALRs) belong to the superfamily of G-protein coupled receptors. The three GALR subtypes (GALR1, GALR2, and GALR3) are activated by their endogenous ligands: spexin (SPX) and galanin (GAL).
Yoo-Na Lee +5 more
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NMR spectroscopy studies to elucidate the role of SPX domains in phosphate homeostasis
, 2021 This PhD thesis focuses on two main areas of research. The first area deals with structural and functional studies of SPX domains in yeast and plants that are key to the understanding of the basis of eukaryotic phosphate (Pi) homeostasis. A better understanding potentially offers a door-opener for future treatment of human primary familial brain ...
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Biomolecules, 2023 Inositol poly- and pyrophosphates (InsPs and PP-InsPs) are central eukaryotic messengers. These very highly phosphorylated molecules can exist in two distinct conformations, a canonical one with five phosphoryl groups in equatorial positions, and a ...
Leonie Kurz +3 more
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Mutational Analysis of theBacillus subtilisRNA Polymerase α C-Terminal Domain Supports the Interference Model of Spx-Dependent Repression [PDF]
Journal of Bacteriology, 2006 ABSTRACTThe Spx protein ofBacillus subtilisexerts both positive and negative transcriptional control in response to oxidative stress by interacting with the C-terminal domain of the RNA polymerase (RNAP) alpha subunit (αCTD). Thus, transcription of thesrfoperon at the onset of competence development, which requires the ComA response regulator of the ...
Ying, Zhang +3 more
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Structural Basis for YjbH Adaptor-Mediated Recognition of Transcription Factor Spx
, 2019 YjbH is a bacterial adaptor protein required for efficient proteolysis of the RNA polymerase-binding transcription factor Spx by the ClpXP protease. We report the structure of YjbH in complex with Spx.
Ekström, Simon +10 more
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Novel pathways of regulation of the transcription factor Spx in Bacillus subtilis [PDF]
, 2018 Spx is a transcription factor present in low G+C Gram-positive bacteria, including Bacillus subtilis and several human pathogens. By direct binding to the αCTD domain of the RNA polymerase, Spx modulates the expression of a large set of genes in B ...
Rojas Tapias, Daniel Fernando
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