Results 11 to 20 of about 1,900,890 (167)

Promoter recognition by a complex of Spx and the C-terminal domain of the RNA polymerase alpha subunit. [PDF]

PLoS ONE, 2010
Spx, an ArsC (arsenate reductase) family member, is a global transcriptional regulator of the microbial stress response and is highly conserved amongst Gram-positive bacteria.
Michiko M Nakano, Ann Lin, Cole S Zuber, Kate J Newberry, Richard G Brennan, Peter Zuber   +5 more
doaj   +5 more sources

Characterization of XPR1/SLC53A1 variants located outside of the SPX domain in patients with primary familial brain calcification. [PDF]

Sci Rep, 2019
AbstractPrimary familial brain calcification (PFBC) is a rare neurological disease characterized by deposits of calcium phosphate in the basal ganglia and other regions of the brain. Pathogenic variants in the XPR1/SLC53A1 gene, which encodes the only known inorganic phosphate exporter, cause an autosomal dominant form of PFBC.
López-Sánchez U, Nicolas G, Richard AC, Maltête D, Charif M, Ayrignac X, Goizet C, Touhami J, Labesse G, Battini JL, Sitbon M.   +10 more
europepmc   +7 more sources

Crystal structure of the in vivo-assembled Bacillus subtilis Spx/RNA polymerase α subunit C-terminal domain complex [PDF]

Journal of Structural Biology, 2009
The Bacillus subtilis Spx protein is a global transcription factor that interacts with the C-terminal domain of the RNA polymerase alpha subunit (alphaCTD) and regulates transcription of genes involved in thiol-oxidative stress, sporulation, competence, and organosulfur metabolism.
Lamour, Valerie, Westblade, Lars, Campbell, Elizabeth, Darst, Seth   +3 more
openaire   +3 more sources

Mining key genes associated with phosphorus deficiency through genome-wide identification and characterization of cucumber SPX family genes

BMC Plant Biology
Background Proteins harboring the SPX domain are crucial for the regulation of phosphate (Pi) homeostasis in plants. This study aimed to identify and analyze the entire SPX gene family within the cucumber genome.
Jialin Li, Linyue Hu, Qianqian Luan, Jingdan Zhang, Xueru Feng, Hongmei Li, Zenghui Wang, Wenxing He   +7 more
doaj   +2 more sources

Evolution of the SPX gene family and its role in the response mechanism to low phosphorus stress in self-rooted apple stock

BMC Genomics
Background Phosphorus plays a key role in plant adaptation to adversity and plays a positive role in the yield and quality formation of apples. Genes of the SPX domain-containing family are widely involved in the regulation of phosphorus signalling ...
Zenghui Wang, Xiaowen Zhang, Xuemei Yang, Haixia Tang, Lijuan Feng, Yanlei Yin, Jialin Li   +6 more
doaj   +2 more sources

Transcriptome assemblies for two drug‐type cannabis chemotypes by long‐read RNA sequencing [PDF]

The Plant Genome
Cannabis sativa has undergone over 10,000 years of domestication, resulting in extensive genetic and phenotypic diversity among cultivated chemotypes. Increased medical and recreational use of specialized metabolites accumulating in cannabis glandular ...
Oliver Berkowitz, Ricarda Jost, Sophia Ng, Antony Bacic, James Whelan, Mathew G. Lewsey   +5 more
doaj   +2 more sources

Transporter-Driven Glycerophosphocholine (GPC) Toxicity Is Conserved from Fission Yeast to Budding Yeast: Roles for Inositol Pyrophosphates and Gde1 Regulation in Fission Yeast [PDF]

Biomolecules
Glycerophosphocholine (GPC) and glycerophosphoinositol (GPI) are phospholipid metabolites generated by phospholipase-mediated deacylation. In budding yeast, they enter cells via the Git1 permease; in fission yeast, the homolog is Tgp1.
Victoria Lee Hrach, Beate Schwer, Lane Vitek, Michael Borowicz, Aleksei Innokentev, Ana M. Sanchez, Justin R. Singer, Stewart Shuman, Jana Patton-Vogt   +8 more
doaj   +2 more sources

Co-expression analysis identifies organ-specific gene regulatory networks responsive to phosphate limitation in hemp (Cannabis sativa L.) [PDF]

BMC Plant Biology
Background Cannabis sativa L. is a compelling model species for studying how human selection has shaped plant traits through domestication. Cannabis hemp-type varieties are grown for fibre and seed, whereas drug-types are cultivated for high cannabinoid ...
Benjamin Wee Y., Ricarda Jost, James Whelan, Oliver Berkowitz   +3 more
doaj   +2 more sources

Genome-Wide Identification and Characterization of SPX Domain-Containing Members and Their Responses to Phosphate Deficiency in Brassica napus. [PDF]

Front Plant Sci, 2017
The importance of SPX domain-encoding proteins to phosphate (Pi) homeostasis and signaling pathways has been well-documented in rice and Arabidopsis. However, global information and responses of SPX members to P stress in allotetraploid Brassica napus, one of the world's major oil crops that is sensitive to P deficiency, remain undefined. We identified
Du H, Yang C, Ding G, Shi L, Xu F.
europepmc   +4 more sources

Untangling Inositol (Pyro)Phosphate Biology Through Emerging Technologies. [PDF]

Adv Sci (Weinh)
Inositol (pyro)phosphates represent a vital class of intracellular messengers that govern multiple biological processes. The last decade has experienced a surge of interest in the functions of this class of signaling molecules, primarily due to the introduction of several innovative analytical technologies.
Saiardi A, Lu M, Zhang Y, Shukla A, Ko AA, Jessen HJ.   +5 more
europepmc   +2 more sources