Results 11 to 20 of about 46,717 (320)

SR-BI: A Multifunctional Receptor in Cholesterol Homeostasis and Atherosclerosis. [PDF]

Trends Endocrinol Metab, 2017
The HDL receptor scavenger receptor class B type I (SR-BI) plays crucial roles in cholesterol homeostasis, lipoprotein metabolism, and atherosclerosis. Hepatic SR-BI mediates reverse cholesterol transport (RCT) by the uptake of HDL cholesterol for routing to the bile.
Linton MF, Tao H, Linton EF, Yancey PG.
europepmc   +4 more sources

SR-BI mediates neutral lipid sorting from LDL to lipid droplets and facilitates their formation. [PDF]

PLoS ONE, 2020
SR-BI binds various lipoproteins, including HDL, LDL as well as VLDL, and mediates selective cholesteryl ester (CE) uptake. HDL derived CE accumulates in cellular lipid droplets (LDs), which also store triacylglycerol (TAG).
Tatyana G Vishnyakova, Alexander V Bocharov, Irina N Baranova, Roger Kurlander, Steven K Drake, Zhigang Chen, Marcelo Amar, Denis Sviridov, Boris Vaisman, Eugenia Poliakov, Alan T Remaley, Thomas L Eggerman, Amy P Patterson   +12 more
doaj   +2 more sources

Functional characterization of newly-discovered mutations in human SR-BI. [PDF]

PLoS ONE, 2012
In rodents, SR-BI has been firmly established as a physiologically relevant HDL receptor that mediates removal of HDL-cholesteryl esters (CE). However, its role in human lipoprotein metabolism is less defined.
Alexandra C Chadwick, Daisy Sahoo
doaj   +4 more sources

SR-BI in bone marrow derived cells protects mice from diet induced coronary artery atherosclerosis and myocardial infarction. [PDF]

PLoS ONE, 2013
SR-BI deficient mice that are also hypomorphic for apolipoprotein E expression develop diet induced occlusive coronary artery atherosclerosis, myocardial infarction and early death.
Ying Pei, Xing Chen, Dina Aboutouk, Mark T Fuller, Omid Dadoo, Pei Yu, Elizabeth J White, Suleiman A Igdoura, Bernardo L Trigatti   +8 more
doaj   +1 more source

Accelerated Lipid Absorption in Mice Overexpressing Intestinal SR-BI [PDF]

Journal of Biological Chemistry, 2006
Dietary cholesterol absorption contributes to a large part of the circulating cholesterol. However, the mechanism of sterol intestinal uptake is not clearly elucidated. Scavenger receptor class B type I (SR-BI), major component in the control of cholesterol homeostasis, is expressed in the intestine, but its role in this organ remains unclear.
Bietrix, Florence, Yan, Daoguang, Nauze, Michel, Rolland, Corinne, Bertrand-Michel, Justine, Coméra, Christine, Schaak, Stephane, Barbaras, Ronald, Groen, Albert K., Perret, Bertrand, Tercé, François, Collet, Xavier   +11 more
openaire   +3 more sources

Receptor complementation and mutagenesis reveal SR-BI as an essential HCV entry factor and functionally imply its intra- and extra-cellular domains. [PDF]

PLoS Pathogens, 2009
HCV entry into cells is a multi-step and slow process. It is believed that the initial capture of HCV particles by glycosaminoglycans and/or lipoprotein receptors is followed by coordinated interactions with the scavenger receptor class B type I (SR-BI),
Marlène Dreux, Viet Loan Dao Thi, Judith Fresquet, Maryse Guérin, Zélie Julia, Géraldine Verney, David Durantel, Fabien Zoulim, Dimitri Lavillette, François-Loïc Cosset, Birke Bartosch   +10 more
doaj   +1 more source

SR-BI Selective Lipid Uptake [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2009
Objective— The purpose of this study was to investigate the interaction of SAA and SR-BI in remodeling of acute phase HDL (AP HDL). Methods and Results— We used SAA and SR-BI adenoviral vector expression models to study the ...
Maria C, de Beer, Nancy R, Webb, Nathan L, Whitaker, Joanne M, Wroblewski, Anisa, Jahangiri, Deneys R, van der Westhuyzen, Frederick C, de Beer   +6 more
openaire   +2 more sources

Scavenger receptor SR-BI in macrophage lipid metabolism [PDF]

Atherosclerosis, 2011
To investigate the mechanisms by which macrophage scavenger receptor BI (SR-BI) regulates macrophage cholesterol homeostasis and protects against atherosclerosis.The expression and function of SR-BI was investigated in cultured mouse bone marrow-derived macrophages (BMM).
Ailing, Ji, Jason M, Meyer, Lei, Cai, Akinwunmi, Akinmusire, Maria C, de Beer, Nancy R, Webb, Deneys R, van der Westhuyzen   +6 more
openaire   +2 more sources

Hepatoma cell density promotes claudin-1 and scavenger receptor BI expression and hepatitis C virus internalization. [PDF]

, 2009
Hepatitis C virus (HCV) entry occurs via a pH- and clathrin-dependent endocytic pathway and requires a number of cellular factors, including CD81, the tight-junction proteins claudin 1 (CLDN1) and occludin, and scavenger receptor class B member I (SR-BI).
Balfe, Peter, Grove, Joe, Hu, Ke, McKeating, Jane A, Mee, Christopher J, Schwarz, Anne K   +5 more
core   +2 more sources

Indolinyl-Thiazole Based Inhibitors of Scavenger Receptor-BI (SR-BI)-Mediated Lipid Transport [PDF]

, 2014
A potent class of indolinyl-thiazole based inhibitors of cellular lipid uptake mediated by scavenger receptor, class B, type I (SR-BI) was identified via a high-throughput screen of the National Institutes of Health Molecular Libraries Small Molecule ...
Bennion, Melissa, Dandapani, Sivaraman, Dockendorff, Chris, Faloon, Patrick W., Krieger, Monty, Lam, Garrett, Lewis, Timothy A., Munoz, Benito, Nag, Partha P., Negri, Joseph, Nieland, Thomas J.F., Palmer, Michelle A., Paterson, Conor, Penman, Marsha, Perez, José R., Pu, Jun, Schreiber, Stuart L., Youngsaye, Willmen, Yu, Miao   +18 more
core   +3 more sources