SR-BI/CD36 chimeric receptors define extracellular subdomains of SR-BI critical for cholesterol transport. [PDF]
Biochemistry, 2014 High-density lipoproteins (HDLs) are athero-protective, primarily because of their ability to promote cholesterol flux from peripheral tissues to the liver by reverse cholesterol transport (RCT).
Kartz GA +3 more
europepmc +6 more sources
SR-BI: A Multifunctional Receptor in Cholesterol Homeostasis and Atherosclerosis. [PDF]
Trends Endocrinol Metab, 2017 The HDL receptor scavenger receptor class B type I (SR-BI) plays crucial roles in cholesterol homeostasis, lipoprotein metabolism, and atherosclerosis. Hepatic SR-BI mediates reverse cholesterol transport (RCT) by the uptake of HDL cholesterol for routing to the bile.
Linton MF, Tao H, Linton EF, Yancey PG.
europepmc +6 more sources
Baicalin promotes cholesterol efflux by regulating the expression of SR-BI in macrophages. [PDF]
Exp Ther Med, 2016 Intake of a high dosage of baicalin has previously been shown to attenuate hyperlipidemia induced by a high-fat diet. Baicalin functions as an activator of peroxisome proliferator-activated receptor-γ (PPAR-γ), which is the key regulator of reverse ...
Yu R +9 more
europepmc +6 more sources
Functional characterization of newly-discovered mutations in human SR-BI. [PDF]
PLoS ONE, 2012 In rodents, SR-BI has been firmly established as a physiologically relevant HDL receptor that mediates removal of HDL-cholesteryl esters (CE). However, its role in human lipoprotein metabolism is less defined.
Alexandra C Chadwick, Daisy Sahoo
doaj +6 more sources
SR-BI in bone marrow derived cells protects mice from diet induced coronary artery atherosclerosis and myocardial infarction. [PDF]
PLoS ONE, 2013 SR-BI deficient mice that are also hypomorphic for apolipoprotein E expression develop diet induced occlusive coronary artery atherosclerosis, myocardial infarction and early death.
Ying Pei +8 more
doaj +2 more sources
SR-BI Interactome Analysis Reveals a Proviral Role for UGGT1 in Hepatitis C Virus Entry [PDF]
Frontiers in Microbiology, 2019 Hepatitis C virus (HCV) entry is mediated by multiple co-receptors including scavenger receptor class B, type I (SR-BI). To elucidate the interactome of human SR-BI, we performed immunoprecipitation (IP) experiment coupled with mass spectrometry (MS ...
Jiazhao Huang +7 more
doaj +2 more sources
Malignant Phenotypes in Metastatic Melanoma are Governed by SR-BI and its Association with Glycosylation and STAT5 Activation. [PDF]
Mol Cancer Res, 2018 Metastatic melanoma is hallmarked by elevated glycolytic flux and alterations in cholesterol homeostasis. The contribution of cholesterol transporting receptors for the maintenance of a migratory and invasive phenotype is not well defined.
Kinslechner K +10 more
europepmc +2 more sources
Human SR-BI and SR-BII Potentiate Lipopolysaccharide-Induced Inflammation and Acute Liver and Kidney Injury in Mice. [PDF]
J Immunol, 2016 The class B scavenger receptors BI (SR-BI) and BII (SR-BII) are high-density lipoprotein receptors that recognize various pathogens, including bacteria and their products.
Baranova IN +13 more
europepmc +2 more sources
S1P in HDL promotes interaction between SR-BI and S1PR1 and activates S1PR1-mediated biological functions: calcium flux and S1PR1 internalization. [PDF]
J Lipid Res, 2017 HDL normally transports about 50–70% of plasma sphingosine 1-phosphate (S1P), and the S1P in HDL reportedly mediates several HDL-associated biological effects and signaling pathways. The HDL receptor, SR-BI, as well as the cell surface receptors for S1P (
Lee MH +8 more
europepmc +2 more sources
A novel assay uncovers an unexpected role for SR-BI in LDL transcytosis. [PDF]
Cardiovasc Res, 2015 AIMS Retention of low-density lipoprotein (LDL) cholesterol beneath the arterial endothelium initiates an inflammatory response culminating in atherosclerosis.
Armstrong SM +15 more
europepmc +2 more sources