Results 21 to 30 of about 878,007 (304)

Alternative forms of the scavenger receptor BI (SR-BI)

Journal of Lipid Research, 1997
The class B, type I scavenger receptor has been implicated as a receptor for high density lipoprotein (HDL). We have isolated a murine cDNA clone encoding an alternative form of SR-BI that differs in the putative cytoplasmic domain of the receptor.
N R Webb, W J de Villiers, P M Connell, F C de Beer, D R van der Westhuyzen   +4 more
doaj   +4 more sources

Macrophage SR-BI mediates efferocytosis via Src/PI3K/Rac1 signaling and reduces atherosclerotic lesion necrosis. [PDF]

J Lipid Res, 2015
Macrophage apoptosis and efferocytosis are key determinants of atherosclerotic plaque inflammation and necrosis. Bone marrow transplantation studies in ApoE- and LDLR-deficient mice revealed that hematopoietic scavenger receptor class B type I (SR-BI ...
Tao H, Yancey PG, Babaev VR, Blakemore JL, Zhang Y, Ding L, Fazio S, Linton MF.   +7 more
europepmc   +2 more sources

Successful anti-scavenger receptor class B type I (SR-BI) monoclonal antibody therapy in humanized mice after challenge with HCV variants with in vitro resistance to SR-BI-targeting agents. [PDF]

Hepatology, 2014
Hepatitis C virus (HCV)‐induced endstage liver disease is currently a major indication for liver transplantation. After transplantation the donor liver inevitably becomes infected with the circulating virus.
Vercauteren K, Van Den Eede N, Mesalam AA, Belouzard S, Catanese MT, Bankwitz D, Wong-Staal F, Cortese R, Dubuisson J, Rice CM, Pietschmann T, Leroux-Roels G, Nicosia A, Meuleman P.   +13 more
europepmc   +2 more sources

SR-BI (Scavenger Receptor Class B Type 1) Is Critical in Maintaining Normal T-Cell Development and Enhancing Thymic Regeneration. [PDF]

Arterioscler Thromb Vasc Biol, 2018
Objective— Continuous T-cell production from thymus is essential in replenishing naïve T-cell pool and maintaining optimal T-cell functions. However, the underlying mechanisms regulating the T-cell development in thymus remains largely unknown.
Zheng Z, Ai J, Guo L, Ye X, Bondada S, Howatt D, Daugherty A, Li XA.   +7 more
europepmc   +2 more sources

SR-BI mediates neutral lipid sorting from LDL to lipid droplets and facilitates their formation. [PDF]

PLoS ONE, 2020
SR-BI binds various lipoproteins, including HDL, LDL as well as VLDL, and mediates selective cholesteryl ester (CE) uptake. HDL derived CE accumulates in cellular lipid droplets (LDs), which also store triacylglycerol (TAG).
Tatyana G Vishnyakova, Alexander V Bocharov, Irina N Baranova, Roger Kurlander, Steven K Drake, Zhigang Chen, Marcelo Amar, Denis Sviridov, Boris Vaisman, Eugenia Poliakov, Alan T Remaley, Thomas L Eggerman, Amy P Patterson   +12 more
doaj   +2 more sources

Macrophage SR-BI regulates LPS-induced pro-inflammatory signaling in mice and isolated macrophages

Journal of Lipid Research, 2012
Scavenger receptor BI (SR-BI), an HDL receptor, plays a key role in reverse cholesterol transport. In mice, disruption of SR-BI results in hypersensitivity to lipopolysaccharide (LPS) and bacteria-induced septic shock due to adrenal insufficiency and ...
Lei Cai, Zhen Wang, Jason M. Meyer, Ailing Ji, Deneys R. van der Westhuyzen   +4 more
doaj   +2 more sources

Intestinal SR-BI does not impact cholesterol absorption or transintestinal cholesterol efflux in mice

Journal of Lipid Research, 2013
Reverse cholesterol transport (RCT) can proceed through the classic hepatobiliary route or through the nonbiliary transintestinal cholesterol efflux (TICE) pathway.
Kanwardeep S. Bura, Caleb Lord, Stephanie Marshall, Allison McDaniel, Gwyn Thomas, Manya Warrier, Jun Zhang, Matthew A. Davis, Janet K. Sawyer, Ramesh Shah, Martha D. Wilson, Arne Dikkers, Uwe J.F. Tietge, Xavier Collet, Lawrence L. Rudel, Ryan E. Temel, J.Mark Brown   +16 more
doaj   +2 more sources

SR-BI-directed HDL-cholesteryl ester hydrolysis

Journal of Lipid Research, 2003
We have examined the metabolic fate of HDL cholesteryl ester (CE) delivered to cells expressing scavenger receptor class B type I (SR-BI). Comparison of SR-BI with a related class B scavenger receptor, CD36, showed a greater uptake and a more rapid and ...
Margery A. Connelly, Ginny Kellner-Weibel, George H. Rothblat, David L. Williams   +3 more
doaj   +4 more sources

Diabetic HDL is dysfunctional in stimulating endothelial cell migration and proliferation due to down regulation of SR-BI expression. [PDF]

PLoS ONE, 2012
Diabetic HDL had diminished capacity to stimulate endothelial cell (EC) proliferation, migration, and adhesion to extracellular matrix. The mechanism of such dysfunction is poorly understood and we therefore sought to determine the mechanistic features ...
Bing Pan, Yijing Ma, Hui Ren, Yubin He, Yongyu Wang, Xiaofeng Lv, Donghui Liu, Liang Ji, Baoqi Yu, Yuhui Wang, Y Eugene Chen, Subramaniam Pennathur, Jonathan D Smith, George Liu, Lemin Zheng   +14 more
doaj   +2 more sources

SR-BI as target in atherosclerosis and cardiovascular disease - A comprehensive appraisal of the cellular functions of SR-BI in physiology and disease. [PDF]

Atherosclerosis, 2017
High-density lipoprotein (HDL) is considered an anti-atherogenic lipoprotein species due to its role in reverse cholesterol transport. HDL delivers cholesterol esters to the liver through selective uptake by scavenger receptor class B type I (SR-BI). In line with the protective role for HDL in the context of cardiovascular disease, studies in mice and ...
M. Hoekstra
semanticscholar   +3 more sources