Arteriosclerosis, Thrombosis, and Vascular Biology, 2003 Monocyte-derived macrophages are among the first cells to accumulate in atherosclerotic lesions. Primarily, they appear to scavenge lipids and lipoproteins from fatty streaks, but their long-term presence and accumulation of cholesterol and cholesteryl esters is the hallmark of atherosclerosis. Atherogenesis begins by a perturbation in the endothelium.
openaire +2 more sources
Journal of Lipid Research, 2006 Scavenger receptor class B type I (SR-BI) mediates the selective uptake of HDL cholesteryl esters (CEs) and facilitates the efflux of unesterified cholesterol. SR-BI expression in macrophages presumably plays a role in atherosclerosis.
May Brundert +5 more
doaj +1 more source
Oxidized low-density lipoprotein inhibits hepatitis C virus cell entry in human hepatoma cells. [PDF]
, 2006 Cell entry of hepatitis C virus, pseudoparticles (HCVpp) and cell culture grown virus (HCVcc), requires the interaction of viral glycoproteins with CD81 and other as yet unknown cellular factors.
Boullier, Agnès +6 more
core +1 more source
Initiation of hepatitis C virus infection is dependent on cholesterol and cooperativity between CD81 and scavenger receptor B type I. [PDF]
, 2006 In the past several years, a number of cellular proteins have been identified as candidate entry receptors for hepatitis C virus (HCV) by using surrogate models of HCV infection.
Barth, Heidi +4 more
core +2 more sources
Scavenger receptor BI facilitates the metabolism of VLDL lipoproteins in vivo
Journal of Lipid Research, 2008 Scavenger receptor class B type I (SR-BI) functions as an HDL receptor that promotes the selective uptake of cholesteryl esters (CEs). The physiological role of SR-BI in VLDL metabolism, however, is largely unknown.
Miranda Van Eck +6 more
doaj +1 more source
Neutralizing Antibody-Resistant Hepatitis C Virus Cell-to-Cell Transmission [PDF]
, 2010 Hepatitis C virus (HCV) can initiate infection by cell-free particle and cell-cell contact-dependent transmission. In this study we use a novel infectious coculture system to examine these alternative modes of infection.
Balfe, Peter +12 more
core +4 more sources
Macrophage SR-BI regulates LPS-induced pro-inflammatory signaling in mice and isolated macrophages
Journal of Lipid Research, 2012 Scavenger receptor BI (SR-BI), an HDL receptor, plays a key role in reverse cholesterol transport. In mice, disruption of SR-BI results in hypersensitivity to lipopolysaccharide (LPS) and bacteria-induced septic shock due to adrenal insufficiency and ...
Lei Cai +4 more
doaj +1 more source
Identification of a residue in hepatitis C virus E2 glycoprotein that determines scavenger receptor BI and CD81 receptor dependency and sensitivity to neutralizing antibodies. [PDF]
, 2008 Hepatitis C virus (HCV) infection is dependent on at least three coreceptors: CD81, scavenger receptor BI (SR-BI), and claudin-1. The mechanism of how these molecules coordinate HCV entry is unknown.
Balfe, Peter +6 more
core +3 more sources
17β-Estradiol promotes the up-regulation of SR-BII in HepG2 cells and in rat livers
Journal of Lipid Research, 2001 The scavenger receptor class B type I (SR-BI) binds to HDL and mediates the selective uptake of cholesterol esters from HDL to cells. SR-BII is an alternatively spliced product of the SR-BI gene that only differs in the C-terminal cytoplasmic domain ...
Gregory A. Graf +2 more
doaj +1 more source
Journal of Lipid Research, 2001 The current study used the human Caco-2 cell line and mouse intestine to explore the topology of expression of the class B type I scavenger receptor (SR-BI) in intestinal cells.
Sheng F. Cai +3 more
doaj +1 more source