Results 31 to 40 of about 878,007 (304)

C323 of SR-BI is required for SR-BI-mediated HDL binding and cholesteryl ester uptake. [PDF]

J Lipid Res, 2011
Scavenger receptor BI (SR-BI) is an HDL receptor. It binds HDL and mediates the uptake of cholesteryl ester from HDL. Early studies have pointed out that the extracellular domain of SR-BI is critical for SR-BI-mediated cholesteryl ester uptake. However, the extracellular loop of SR-BI is large: it contains 403 amino acids.
Guo L, Chen M, Song Z, Daugherty A, Li XA.   +4 more
europepmc   +6 more sources

SR-BI as a target of natural products and its significance in cancer [PDF]

Seminars in Cancer Biology, 2022
Scavenger receptor class B type I (SR-BI) protein is an integral membrane glycoprotein. SR-BI is emerging as a multifunctional protein, which regulates autophagy, efferocytosis, cell survival and inflammation. It is well known that SR-BI plays a critical role in lipoprotein metabolism by mediating cholesteryl esters selective uptake and the bi ...
Wang, Dongdong, Huang, Jiansheng, Gui, Ting, Yang, Yaxin, Feng, Tingting, Tzvetkov, Nikolay T, Xu, Tao, Gai, Zhibo, Zhou, Ying, Zhang, Jingjie, Atanasov, Atanas G   +10 more
openaire   +4 more sources

Endothelial HMGB1 Is a Critical Regulator of LDL Transcytosis via an SREBP2–SR-BI Axis

Arteriosclerosis, Thrombosis and Vascular Biology, 2020
Supplemental Digital Content is available in the text. Objective: LDL (low-density lipoprotein) transcytosis across the endothelium is performed by the SR-BI (scavenger receptor class B type 1) receptor and contributes to atherosclerosis.
S. Ghaffari, Erika Jang, Farnoosh Naderinabi, R. Sanwal, Negar Khosraviani, Changsen Wang, B. Steinberg, N. Goldenberg, Jiro Ikeda, Warren L. Lee   +9 more
semanticscholar   +1 more source

Receptor complementation and mutagenesis reveal SR-BI as an essential HCV entry factor and functionally imply its intra- and extra-cellular domains. [PDF]

PLoS Pathogens, 2009
HCV entry into cells is a multi-step and slow process. It is believed that the initial capture of HCV particles by glycosaminoglycans and/or lipoprotein receptors is followed by coordinated interactions with the scavenger receptor class B type I (SR-BI),
Marlène Dreux, Viet Loan Dao Thi, Judith Fresquet, Maryse Guérin, Zélie Julia, Géraldine Verney, David Durantel, Fabien Zoulim, Dimitri Lavillette, François-Loïc Cosset, Birke Bartosch   +10 more
doaj   +1 more source

Diffusion of Sr, Bi, and Ta in amorphous SiO2 [PDF]

Materials Science in Semiconductor Processing, 2003
Abstract Diffusion of Sr, Bi, and Ta in SiO2 was studied to determine diffusion coefficients and diffusion mechanisms of these elements in the amorphous material. Technological motivation is the introduction of strontium bismuth tantalate (SBT) as ferroelectric material for nonvolatile memories.
Werner Pamler, Ralf Büngener, Ralf Büngener, Ulrich Gösele   +3 more
openaire   +2 more sources

Accelerated Lipid Absorption in Mice Overexpressing Intestinal SR-BI [PDF]

Journal of Biological Chemistry, 2006
Dietary cholesterol absorption contributes to a large part of the circulating cholesterol. However, the mechanism of sterol intestinal uptake is not clearly elucidated. Scavenger receptor class B type I (SR-BI), major component in the control of cholesterol homeostasis, is expressed in the intestine, but its role in this organ remains unclear.
Bietrix, Florence, Yan, Daoguang, Nauze, Michel, Rolland, Corinne, Bertrand-Michel, Justine, Coméra, Christine, Schaak, Stephane, Barbaras, Ronald, Groen, Albert,, Perret, Bertrand, Tercé, François, Collet, Xavier   +11 more
openaire   +4 more sources

Phytoene and Phytofluene Isolated from a Tomato Extract are Readily Incorporated in Mixed Micelles and Absorbed by Caco‐2 Cells, as Compared to Lycopene, and SR‐BI is Involved in their Cellular Uptake

Molecular Nutrition & Food Research, 2018
SCOPE Absorption mechanisms of phytoene (PT) and phytofluene (PTF) are poorly known. The main objectives of the study are to measure their micellization and intestinal cell uptake efficiencies and to compare them to those of commonly consumed carotenoids.
Paula Mapelli-Brahm, C. Desmarchelier, Marielle Margier, E. Reboul, Antonio J. Meléndez Martínez, P. Borel   +5 more
semanticscholar   +1 more source

SR-BI [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2003
Monocyte-derived macrophages are among the first cells to accumulate in atherosclerotic lesions. Primarily, they appear to scavenge lipids and lipoproteins from fatty streaks, but their long-term presence and accumulation of cholesterol and cholesteryl esters is the hallmark of atherosclerosis. Atherogenesis begins by a perturbation in the endothelium.
openaire   +3 more sources

Quercetin induces the selective uptake of HDL-cholesterol via promoting SR-BI expression and the activation of the PPARγ/LXRα pathway.

Food & Function, 2018
Reverse cholesterol transport (RCT) is the process to deliver cholesterol to the liver for further excretion and involves scavenger receptor class B type I (SR-BI)-mediated selective lipid uptake (SLU) from high-density lipoprotein cholesterol (HDL-C ...
Kun Ren, Ting Jiang, Guo-Jun Zhao
semanticscholar   +1 more source

Scavenger receptor SR-BI in macrophage lipid metabolism [PDF]

Atherosclerosis, 2011
To investigate the mechanisms by which macrophage scavenger receptor BI (SR-BI) regulates macrophage cholesterol homeostasis and protects against atherosclerosis.The expression and function of SR-BI was investigated in cultured mouse bone marrow-derived macrophages (BMM).
Deneys R. van der Westhuyzen, Ailing Ji, Lei Cai, Jason M. Meyer, Nancy R. Webb, Maria C. de Beer, Akinwunmi Akinmusire   +6 more
openaire   +3 more sources