Results 31 to 40 of about 46,717 (320)

Human variant of scavenger receptor BI (R174C) exhibits impaired cholesterol transport functions

Journal of Lipid Research, 2021
: HDL and its primary receptor, scavenger receptor class B type I (SR-BI), work together to promote the clearance of excess plasma cholesterol, thereby protecting against atherosclerosis. Human variants of SR-BI have been identified in patients with high
Sarah C. May, Jacqueline S. Dron, Robert A. Hegele, Daisy Sahoo   +3 more
doaj   +1 more source

A library of infectious hepatitis C viruses with engineered mutations in the E2 gene reveals growth-adaptive mutations that modulate interactions with scavenger receptor class B type I [PDF]

, 2016
While natural hepatitis C virus (HCV) infection results in highly diverse quasispecies of related viruses over time, mutations accumulate more slowly in tissue culture, in part because of the inefficiency of replication in cells.
Chen, Kevin, Diamond, Michael S, Evans, Matthew J, Fremont, Daved H, Luca, Vincent C, Schwarz, Megan C, Wang, David, White, James P, Zuiani, Adam   +8 more
core   +2 more sources

Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease. [PDF]

, 2016
Scavenger receptor BI (SR-BI) is the major receptor for high-density lipoprotein (HDL) cholesterol (HDL-C). In humans, high amounts of HDL-C in plasma are associated with a lower risk of coronary heart disease (CHD). Mice that have depleted Scarb1 (SR-BI
Abecasis, G., Al Shafi Majumder, A., Alam, D.S., Amouyel, P., Arveiler, D., Blankenberg, S., Butterworth, A.S., CARDIoGRAM Exome Consortium (), CHD Exome Consortium (), Chowdhury, R., Cuchel, M., Danesh, J., de Craen, A.J., Deloukas, P., Derohannessian, S.L., di Angelantonio, E., Erdmann, J., Ferrario, M., Ferrieres, J., Ford, I., Global Lipids Genetics Consortium (), Hancock-Cerutti, W.F., Howson, J.M.M., Jukema, J.W., Kathiresan, S., Kee, F., Khetarpal, S.A., Kontush, A., Kuulasmaa, K., Larach, D.B., Liu, D.J., Millar, J.S., Männistö, S., Müller-Nurasyid, M., Nielsen, S.F., Nørdestgaard, B.G., Packard, C., Peloso, G.M., Perola, M., Rader, D.J., Saleheen, D., Salomaa, V., Samani, N., Sattar, N., Schmidt, R.F., Schunkert, H., Stitziel, N.O., Surendran, P., Trompet, S., Tybjærg-Hansen, A., Willer, C.J., Zanoni, P.   +51 more
core   +1 more source

Excess cholesterol induces mouse egg activation and may cause female infertility [PDF]

, 2013
The HDL receptor scavenger receptor, class B type I (SR-BI) controls the structure and fate of plasma HDL. Female SR-BI KO mice are infertile, apparently because of their abnormal cholesterol-enriched HDL particles.
Albertini, David F., Busso, Dolores, Chavarria, Tony E, Dekel, Nava, Dokshin, Gregoriy A., Galiani, Dalia, Krieger, Monty, Orellana, Juan Andrés, Page, David C, Quilaqueo, Linda, Rigotti, Attilio, Shalgi, Ruth, Vasile, Eliza, Walzer, Dalia F., Wang, Li, Yesilaltay, Ayce   +15 more
core   +1 more source

Scavenger receptor class B type I localizes to a late endosomal compartment

Journal of Lipid Research, 2008
Scavenger receptor class B type I (SR-BI) has an established role in mediating the selective uptake of cholesterol from HDL in hepatocytes, steroidogenic cells, and other tissues.
Malika Ahras, Thet Naing, Ruth McPherson
doaj   +1 more source

Induction of adrenal scavenger receptor BI and increased high density lipoprotein-cholesteryl ether uptake by in vivo inhibition of hepatic lipase [PDF]

, 1998
Hepatic lipase (HL) and scavenger receptor type B class I (SR-BI) have both been implicated in high density lipoprotein (HDL)-cholesteryl ester uptake in cholesterol-utilizing tissues.
Gent, T. (Teus) van, Jansen, H. (Hans), Kalkman, I. (Ina), Tol, A. (Arie) van, Vieira-van Bruggen, M.D. (Delfina)   +4 more
core   +1 more source

Influence of HDL-cholesterol-elevating drugs on the in vitro activity of the HDL receptor SR-BI

Journal of Lipid Research, 2007
Treatment of atherosclerotic disease often focuses on reducing plasma LDL-cholesterol or increasing plasma HDL-cholesterol. We examined in vitro the effects on HDL receptor [scavenger receptor class B type I (SR-BI)] activity of three classes of clinical
Thomas J.F. Nieland, Jared T. Shaw, Firoz A. Jaipuri, Zoltan Maliga, Jay L. Duffner, Angela N. Koehler, Monty Krieger   +6 more
doaj   +1 more source

High-density lipoprotein contribute to G0-G1/S transition in Swiss NIH/3T3 fibroblasts [PDF]

, 2015
High density lipoproteins (HDLs) play a crucial role in removing excess cholesterol from peripheral tissues. Although their concentration is lower during conditions of high cell growth rate (cancer and infections), their involvement during cell ...
ACCOSSU, SIMONETTA, ANGIUS, FABRIZIO, BANNI, SEBASTIANO, BATETTA, BARBARA, COLLU, MARIA, DELIGIA, STEFANIA, FRAU, ALESSANDRA, MADEDDU, CLELIA, SERPE, ROBERTO, SPOLITU, STEFANO, UDA, SABRINA   +10 more
core   +1 more source

Hepatic lipase mediates an increase in selective uptake of HDL-associated cholesteryl esters by cells in culture independent from SR-BI

Journal of Lipid Research, 2003
Scavenger receptor class B type I (SR-BI) mediates the selective uptake of HDL cholesteryl esters (CEs) by the liver. Hepatic lipase (HL) promotes this lipid uptake independent from lipolysis.
May Brundert, Joerg Heeren, Heiner Greten, Franz Rinninger   +3 more
doaj   +1 more source

Rare SCARB1 mutations associate with high-density lipoprotein cholesterol but not with coronary artery disease [PDF]

, 2018
To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked FilesAIMS: Scavenger receptor Class B Type 1 (SR-BI) is a major receptor for high ...
Arnadottir, Gudny A, Eyjolfsson, Gudmundur I, Gretarsdottir, Solveig, Gudbjartsson, Daniel F, Helgadottir, Anna, Holm, Hilma, Jensson, Brynjar Ö, Olafsson, Isleifur, Sigurdardottir, Olof, Stefansson, Kari, Sulem, Patrick, Thorgeirsson, Gudmundur, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur   +13 more
core   +2 more sources