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Perturbation of the circadian clock in chronic diseases involving organ fibrosis. [PDF]
J Clin InvestMukherji A +3 more
europepmc +1 more source
Exercise pills for cardiometabolic health cannot mimic the exercise milieu. [PDF]
Trends Endocrinol MetabPlaza-Florido A +7 more
europepmc +1 more source
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Anti-influenza virus activity of the REV-ERBα agonist SR9009 and related analogues
Antiviral Research, 2022REV-ERBα is a member of the nuclear receptor superfamily of transcription factors that aids in the regulation of many diseases. However, the prospect of using REV-ERBα for anti-influenza virus treatment remains poorly described, and there is an urgent ...
Yunyun Cheng +11 more
exaly +4 more sources
Bioorganic and Medicinal Chemistry
SR9009 is an activator of REV-ERBs with diverse biological activities, including improving exercise tolerance and controlling skeletal muscle mass. To optimise the carbamate motif of SR9009, analogues of SR9009 were synthesised and evaluated. All of them
Lei Li +13 more
exaly +4 more sources
SR9009 is an activator of REV-ERBs with diverse biological activities, including improving exercise tolerance and controlling skeletal muscle mass. To optimise the carbamate motif of SR9009, analogues of SR9009 were synthesised and evaluated. All of them
Lei Li +13 more
exaly +4 more sources
Drug Testing and Analysis, 2022
SR9009 and SR9011 are metabolic modulators pharmacologically targeting REV-ERB receptors as synthetic agonists. A liquid chromatography-tandem mass spectrometry method for the detection of SR9009 and SR9011 in equine plasma was developed and validated ...
Hye Hyun Yoo, Young Beom Kwak
exaly +4 more sources
SR9009 and SR9011 are metabolic modulators pharmacologically targeting REV-ERB receptors as synthetic agonists. A liquid chromatography-tandem mass spectrometry method for the detection of SR9009 and SR9011 in equine plasma was developed and validated ...
Hye Hyun Yoo, Young Beom Kwak
exaly +4 more sources
Cellular and Molecular Neurobiology, 2021
REV-ERBs are heme-binding nuclear receptors that regulate the circadian rhythm and play important roles in the regulation of proliferation and the neuronal differentiation process in neuronal stem/progenitor cells in the adult brain. However, the effects of REV-ERB activation in the adult brain remain unclear. In this study, SR9009, a synthetic REV-ERB
Koji Shimozaki
exaly +4 more sources
REV-ERBs are heme-binding nuclear receptors that regulate the circadian rhythm and play important roles in the regulation of proliferation and the neuronal differentiation process in neuronal stem/progenitor cells in the adult brain. However, the effects of REV-ERB activation in the adult brain remain unclear. In this study, SR9009, a synthetic REV-ERB
Koji Shimozaki
exaly +4 more sources
European Journal of Pharmacology
The circadian clock protein reverse erythroblastosis virus (REV)-ERBα is implicated in the pathogenesis of various diseases, including cancer and myocardial infarction.
Kumi Satoh, Akira Takaguri
exaly +4 more sources
The circadian clock protein reverse erythroblastosis virus (REV)-ERBα is implicated in the pathogenesis of various diseases, including cancer and myocardial infarction.
Kumi Satoh, Akira Takaguri
exaly +4 more sources
Journal of Pharmaceutical and Biomedical Analysis
SR9009, a peroxisome proliferator-activated receptor δ (PPARδ) agonist, is known for its potential benefits in energy homeostasis. It failed to receive the United States Food and Drug Administration (USFDA) approval and its illegal distribution has ...
Hye Hyun Yoo +2 more
exaly +4 more sources
SR9009, a peroxisome proliferator-activated receptor δ (PPARδ) agonist, is known for its potential benefits in energy homeostasis. It failed to receive the United States Food and Drug Administration (USFDA) approval and its illegal distribution has ...
Hye Hyun Yoo +2 more
exaly +4 more sources
Biochemical Pharmacology, 2021
The circadian clock plays an important role in adapting organisms to the daily light/dark cycling environment. Recent research findings reveal the involvement of the circadian clock not only in physiological functions but also in regulating inflammatory responses under pathological situations.
Huiling Hong +5 more
semanticscholar +3 more sources
The circadian clock plays an important role in adapting organisms to the daily light/dark cycling environment. Recent research findings reveal the involvement of the circadian clock not only in physiological functions but also in regulating inflammatory responses under pathological situations.
Huiling Hong +5 more
semanticscholar +3 more sources