Results 151 to 160 of about 111,466 (171)

Src family kinase function during earlyXenopus development

Developmental Dynamics, 2001
The Src family kinase Laloo functions downstream of the fibroblast growth factor (FGF) receptor, as a component of a signaling pathway required for mesoderm formation. In this study, we first show that Laloo expression can mimic FGF function in a distinct context, suggesting that the Src-related kinases are general transducers of FGF signaling during ...
D C, Weinstein, A A, Hemmati-Brivanlou
openaire   +2 more sources

Fyn, a Src family tyrosine kinase

The International Journal of Biochemistry & Cell Biology, 1998
Fyn is a 59 kDa member of the Src family of tyrosine kinases. The protein is synthesized and N-myristoylated on cytosolic polysomes and then rapidly targeted to the plasma membrane, where it is palmitoylated. Dually acylated Fyn clusters in caveolae-like membrane microdomains, and can interact with a variety of other signaling molecules.
openaire   +2 more sources

SRC family kinases in cell volume regulation

American Journal of Physiology-Cell Physiology, 2005
SRC family kinases are a group of nine cytoplasmic protein tyrosine kinases essential for many cell functions. Some appear to be ubiquitously expressed, whereas others are highly tissue specific. The ability of members of the SRC family to influence ion transport has been recognized for several years.
openaire   +2 more sources

Regulation of src family tyrosine kinases in lymphocytes

Trends in Biochemical Sciences, 1993
An immune response is initiated by activation of antigen-specific lymphoid cells via receptors on the cell surface. Recent advances have begun to unravel the molecular pathways by which the signals from these surface receptors are transduced into the cells and affect the cell's behavior.
T, Mustelin, P, Burn
openaire   +2 more sources

Src family kinases in tumor progression and metastasis

Cancer and Metastasis Reviews, 2003
The Src family of non-receptor protein tyrosine kinases plays critical roles in a variety of cellular signal transduction pathways, regulating such diverse processes as cell division, motility, adhesion, angiogenesis, and survival. Constitutively activated variants of Src family kinases, including the viral oncoproteins v-Src and v-Yes, are capable of ...
Justin M, Summy, Gary E, Gallick
openaire   +2 more sources

Src Family Kinase for Wnt5 Signaling

Science Signaling, 2008
Although most members of the Wnt [Wingless (Wg) in flies] family of ligands signal through seven-transmembrane receptors of the Frizzled family, Wnt5 binds to receptor tyrosine kinase-like proteins called RYKs [ROR in mammals and Derailed (Drl) in flies]. RYKs lack conserved residues that are important for kinase activity and so are likely
openaire   +1 more source

Structure and dynamic regulation of Src-family kinases

Cellular and Molecular Life Sciences, 2008
Src-family kinases are modular signaling proteins involved in a diverse array of cellular processes. All members of the Src family share the same domain organization, with modular SH3, SH2 and kinase domains followed by a C-terminal negative regulatory tail.
J R, Engen, T E, Wales, J M, Hochrein, M A, Meyn, S, Banu Ozkan, I, Bahar, T E, Smithgall   +6 more
openaire   +2 more sources

Src-family kinases: rheostats of immune cell signaling

Molecular Immunology, 2004
In immune cells, Src-family kinases have been implicated as critical regulators of a large number of intracellular signaling pathways. Studies of gene knockout mice lacking various family members have both confirmed the requirement for these kinases in some pathways and provided surprising insight into their roles in other pathways. In many cases, loss
openaire   +2 more sources

Src Family Tyrosine Kinases ☆

2017
M.C. Frame, R. Roskoski
openaire   +1 more source

Kinases/Phosphatases | Src Family of Protein Tyrosine Kinases

2021
Jonathan A. Cooper, Vivian Kitainda
openaire   +1 more source