Results 151 to 160 of about 80,567 (286)

Post‐Translational Modifications of Key Proteins in Hematologic Malignancies: Carcinogenic Mechanisms, Biomarker Potential, and New Therapeutic Strategies

iLABMED, EarlyView.
This article reviews the pivotal role of post‐translational modifications of proteins in the development and progression of hematologic malignancies, and explores their clinical translation potential as novel biomarkers and therapeutic targets. ABSTRACT Post‐translational modifications (PTMs) of proteins have emerged as critical regulators in the ...
Yuxuan Han, Chaowei Zhang, Weiyi Yao, Qing Hong, Xinyu Tang, Yanan Zhu, Na Chen   +6 more
wiley   +1 more source

c-Kit Receptor Maintains Sensory Axon Innervation of the Skin through Src Family Kinases. [PDF]

J Neurosci, 2022
Tuttle AM, Pomaville MB, Delgado KC, Wright KM, Nechiporuk AV.   +4 more
europepmc   +1 more source

Inhibition of Src family kinases improves cognitive function after intraventricular hemorrhage or intraventricular thrombin

, 2017
Intraventricular hemorrhage causes spatial memory loss, but the mechanism remains unknown. Our recent studies demonstrated that traumatic brain injury activates Src family kinases, which cause spatial memory loss.
Waldau, Ben, Stamova, Boryana, Da Zhi Liu, Bradley P Ander, Bruce G Lyeth, Frank R Sharp, Ander, Bradley P, Jickling, Glen C, Xinhua Zhan, Lyeth, Bruce G, Liu, Da Zhi, Glen C Jickling, Boryana Stamova, Ben Waldau, Sharp, Frank R, Zhan, Xinhua   +15 more
core   +1 more source

Gene expression signatures from single‐cell transcriptomics predict Sjögren's syndrome

iMetaOmics, EarlyView.
A machine learning‐based 12‐gene signature (SjS.Sig) was developed from scRNA‐seq data of PBMCs from Sjögren's syndrome patients. The model was validated using bulk RNA‐seq datasets and further confirmed through flow cytometry and qPCR analysis in an independent clinical cohort, demonstrating robust diagnostic potential.
Shumin Cheng, Ling Yan, Yilin Wu, Yan Li, Ziheng Ye, Zhen Zhang, Yi Zhang, Jingyun Ma, Yuhong Liang, Zhaofan Luo, Huacheng Wang, Meili Gao, Chao Qin, Ke Zhu, Yun Leng, Kamran Ullah, Jun Liang, Haiyan Yan, Guan Yang, Yingqian Mo, Bihui Huang   +20 more
wiley   +1 more source

Opposite Effects of Src Family Kinases on YAP and ERK Activation in Pancreatic Cancer Cells: Implications for Targeted Therapy. [PDF]

Mol Cancer Ther, 2022
Sinnett-Smith J, Anwar T, Reed EF, Teper Y, Eibl G, Rozengurt E.   +5 more
europepmc   +1 more source

Role of the Src Family Tyrosine Kinases in Mammary Tumorigenesis

, 1995
Although previous studies have shown that a large proportion of human breast cancers possess elevated c-Src kinase activity its role in mammary tumorigenesis is not well defined.
Muthuswamy, Senthil K.
core  

A compendium of extracellular vesicle biogenesis inhibitors: From bench to bedside

Interdisciplinary Medicine, EarlyView.
This review explores a decade of research on extracellular vesicles (EVs), detailing their biogenesis and roles in health and disease. It emphasizes EVs' relevance for potential medical applications covering various conditions such as cancer, neurodegeneration, inflammation, and infectious diseases, bridging experimental findings with clinical ...
Stefano Vecchione, Ana Talamillo, Juan M. Falcón‐Pérez   +2 more
wiley   +1 more source

Identification of Src Family Kinases as Potential Therapeutic Targets for Chemotherapy-Resistant Triple Negative Breast Cancer. [PDF]

Cancers (Basel), 2022
Kohale IN, Yu J, Zhuang Y, Fan X, Reddy RJ, Sinnwell J, Kalari KR, Boughey JC, Carter JM, Goetz MP, Wang L, White FM.   +11 more
europepmc   +1 more source

c‐Met‐Targeted Imaging Agents: Progress and Challenges

iRADIOLOGY, EarlyView.
This review summarizes recent advances in c‐Met‐targeted imaging probes, including hepatocyte growth factor (HGF) ligands, antibodies, peptides, and small molecules across magnetic resonance imaging (MRI), positron emission tomography (PET), single‐photon emission computed tomography (SPECT), and optical imaging modalities.
Yonghao Li, Aiyan Ji, Qihang Ding, Hongyue Lou, Zhen Cheng   +4 more
wiley   +1 more source

Src family kinases are essential for primary aggregation by G(i)-coupled receptors

, 2010
Introduction and Background: Adrenaline stimulates biphasic aggregation in plasma through the G(i)-coupled alpha(2A)-adrenoreceptor. In the present study, we demonstrate that both primary and secondary wave aggregation induced by adrenaline in plasma is ...
B.B. DAWOOD, J. WILDE, Y.A. SENIS, S.P. WATSON, Dawood, Ban, Senis, YA, C.A. NASH, M. MAKRIS, Senis, Yotis, S. SÉVERIN, A. MUMFORD, Severin, Sonia, Wilde, Johnathan, Mumford, AD, Dawood, BB, Makris, M, Wilde, J, Watson, Steve; id_orcid, Nash, CA, Mumford, A, Severin, S, Watson, SP   +21 more
core   +1 more source