Results 151 to 160 of about 61,468 (247)

Mechanical stiffness orchestrates distinct regulation of MRTFs and YAP/TAZ transcriptional cofactors in hepatocytes

The FEBS Journal, EarlyView.
MRTFs and YAP/TAZ proteins, or mechanosensitive transcriptional cofactors (MRTcoF), regulate common genes associated with cellular contractility and immune cell infiltration. Their differential regulation in response to stiffness is linked to changes in hepatocyte's aspect ratio. MRTFB does not undergo nuclear translocation under these conditions. This
Brenda Selene Torres‐Ortiz, Daniel Pérez‐Calixto, Jorge Carretero‐Ortega, Aida Gabriela Guzman‐López, Diana Cristina Pinto‐Dueñas, Mariana Hernández‐Juárez, Alejandra Jiménez‐Escobar, Adriana Rodríguez‐Hernández, Beatriz Díaz‐Bello, Nathalia Serna‐Márquez, Miguel Ángel Peña‐Rico, Laura Gómez‐Romero, Francisco Gabriel Vázquez‐Cuevas, Genaro Vázquez‐Victorio   +13 more
wiley   +1 more source

FGF receptor kinase inhibitors exhibit broad antiviral activity by targeting Src family kinases. [PDF]

Cell Mol Life Sci
Stefanova D, Olszewski D, Glitscher M, Bauer M, Ferrarese L, Wüst D, Hildt E, Greber UF, Werner S.   +8 more
europepmc   +1 more source

SRC-Family Kinases in Acute Myeloid Leukaemia and Mastocytosis. [PDF]

Cancers (Basel), 2020
Voisset E, Brenet F, Lopez S, de Sepulveda P.   +3 more
europepmc   +1 more source

CD36‐mediated lipid rewiring in the metabolic adaptation of tumour ecosystems

The FEBS Journal, EarlyView.
Nutrient deprivation drives a lipid‐centric shift in tumour metabolic symbiosis and signalling network. CD36 functions as a bidirectional bridge, transferring fatty acids from stromal donors (adipocytes, CAFs) to the ecosystem tumour‐ and microenvironment‐dependently.
Anna Sebestyén, Viktória Varga, Fatime Szalai, Risa Miyaura, Nóra Förhécz, Bálint Csikós, Rebeka Gelencsér, Zsófia Gábriel, Timea Komlódi, Katalin Dezső, Ildikó Krencz, Dorottya Moldvai   +11 more
wiley   +1 more source

Inhibitors of Src Family Kinases, Inducible Nitric Oxide Synthase, and NADPH Oxidase as Potential CNS Drug Targets for Neurological Diseases. [PDF]

CNS Drugs, 2021
Gage MC, Thippeswamy T.
europepmc   +1 more source

The Biological Basis of the Merlin CP‐GEP Assay: Integrin Signaling and Early Metastatic Competence in Cutaneous Melanoma

International Journal of Dermatology, EarlyView.
Merlin CP‐GEP integrates mechanistic insights into a clinically actionable assay to predict SLN metastasis risk and inform personalized management of cutaneous melanoma. ABSTRACT The recent inclusion of the Merlin clinicopathologic–gene expression profile (CP‐GEP) assay in the National Comprehensive Cancer Network (NCCN) Melanoma Guidelines represents ...
Frank Z. Jing, Alexander Meves
wiley   +1 more source

Gender-different effect of Src family kinases antagonism on photophobia and trigeminal ganglion activity. [PDF]

J Headache Pain
Huang Z, Yao J, Nie L, Nie X, Xiong X, Kõks S, Quinn JP, Kanhere A, Wang M.   +8 more
europepmc   +1 more source

Systemic, Lifestyle and Environmental Modifying Factors in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
A variety of impacting factors in the pathogenesis of periodontitis exist, including systemic, lifestyle, and environmental factors. This review highlights the manifold mechanistic aspects of the link between the pathogenesis of periodontitis, addressing these numerous factors to supplement the long‐standing knowledge of the progression of the disease.
Sabine Elisabeth Groeger, Yuxi Zhou, Jiawen Yong, Lei Wang, Sabine Ruf, Joerg Meyle   +5 more
wiley   +1 more source

Csk controls leukocyte extravasation via local regulation of Src family kinases and cortactin signaling. [PDF]

Front Immunol
Stegmeyer RI, Holstein K, Spring K, Timmerman I, Xia M, Stasch M, Möller T, Nottebaum AF, Vestweber D.   +8 more
europepmc   +1 more source

Multiplexable fluorescence lifetime imaging (FLIM) probes for Abl and Src-family kinases. [PDF]

Chem Commun (Camb), 2020
Jena S, Damayanti NP, Tan J, Pratt ED, Irudayaraj JMK, Parker LL.   +5 more
europepmc   +1 more source