Journal of Pharmacological Sciences, 2011 .: Oxidative stress is considered a major mediator of arteriosclerosis. In vascular smooth muscle cells, oxidative stress–induced cell death (including apoptosis) is probably related to arterial calcification in arteriosclerosis.
Jing Zhao +5 more
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Hybrid and rogue kinases encoded in the genomes of model eukaryotes. [PDF]
PLoS ONE, 2014 The highly modular nature of protein kinases generates diverse functional roles mediated by evolutionary events such as domain recombination, insertion and deletion of domains.
Ramaswamy Rakshambikai +2 more
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Role of Src Family Kinases in Prolactin Signaling
, 2014 Prolactin (PRL) is a polypeptide hormone/cytokine mainly synthesized by the lactotrophic cells of the adenohypophysis. In addition to the best-known role in mammary gland development and the functional differentiation of its epithelium, PRL is involved in regulation of multiple physiological processes in higher organisms contributing to their ...
Martín-Pérez, Jorge +4 more
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Src family kinases and pulmonary fibrosis: A review
Biomedicine & Pharmacotherapy, 2020 Src family kinases (SFKs) is a non-receptor protein tyrosine kinases family. They are crucial in signal transduction and regulation of various cell biological processes, such as proliferation, differentiation and apoptosis. The role and mechanism of SFKs in tumorigenesis have been widely studied. However, more and more studies have also shown that SFKs
Hang, Li +9 more
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TYK2-induced phosphorylation of Y640 suppresses STAT3 transcriptional activity [PDF]
, 2017 STAT3 is a pleiotropic transcription factor involved in homeostatic and host defense processes in the human body. It is activated by numerous cytokines and growth factors and generates a series of cellular effects.
De Bosscher, Karolien +7 more
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Cannabinoid receptor CB2 drives HER2 pro-oncogenic signaling in breast cancer [PDF]
, 2015 Pharmacological activation of cannabinoid receptors elicits antitumoral responses in different models of cancer. However, the biological role of these receptors in tumor physio-pathology is still unknown.
Alkatout, Ibrahim +31 more
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Integrin-mediated traction force enhances paxillin molecular associations and adhesion dynamics that increase the invasiveness of tumor cells into a three-dimensional extracellular matrix. [PDF]
, 2017 Metastasis requires tumor cells to navigate through a stiff stroma and squeeze through confined microenvironments. Whether tumors exploit unique biophysical properties to metastasize remains unclear.
Barnes, J Matthew +20 more
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Endothelial Cell Cortactin Phosphorylation by Src Contributes to Polymorphonuclear Leukocyte Transmigration In Vitro [PDF]
, 2006 The underlying mechanisms that regulate leukocyte transendothelial migration through the vascular endothelium remain unclear. Cortactin is a substrate of Src tyrosine kinases and a regulator of cytoskeletal dynamics.
Kowalski, Jennifer R. +4 more
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Fueling the fire: Src family kinases drive inflammation [PDF]
Journal of Experimental Medicine, 2014 ![Figure][1] Insight from Klaus Ley The Src family kinases (SFK) Hck, Fgr, and Lyn are the main SFKs in neutrophils and monocytes. In this issue, in a tour-de-force study of multiple disease models (autoantibody-induced arthritis [K/B×N serum-transfer], skin inflammation induced ...
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Role of
Malaria Journal, 2008 Background Thrombospondin-related anonymous protein (TRAP) is essential for sporozoite motility and for liver cell invasion. TRAP is a type 1 membrane protein that possesses multiple adhesive domains in its extracellular region.
Malhotra Pawan +3 more
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