Results 151 to 160 of about 512,141 (378)

Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phosphorylation of the E-cadherin/beta-catenin complex in cells transformed with a temperature-sensitive v-SRC gene

Journal of Cell Biology, 1993
Loss of histotypic organization of epithelial cells is a common feature in normal development as well as in the invasion of carcinomas. Here we show that the v-src oncogene is a potent effector of epithelial differentiation and invasiveness.
Jiirgen Behrens, L. Vakaet, R. Friis, E. Winterhager, Frans, Van Roy, M. Mareel, W. Birchmeier   +7 more
semanticscholar   +1 more source

Activation of Kir4.1 Channels by 2‐D08 Promotes Myelin Repair in Multiple Sclerosis

Advanced Science, EarlyView.
Multiple sclerosis causes myelin loss and neurological dysfunction. This study shows that 2‐D08, a small molecule targeting Kir4.1 channels, promotes OPCs differentiation via FYN tyrosine kinase phosphorylation and the FYN/MYRF pathway. It significantly improves myelin repair and motor deficits in EAE mice and marmosets, highlighting its potential as a
Mingdong Liu, Shengyu Jin, Xin Fu, Chong Xie, Yi Chen, Liangtang Chang, Yongheng Fan, Donghua He, Xiaoqi Hong, Xi Shen, Xiaoli Zheng, Qiyue Wang, Dao Shi, Fangyuan Li, Daishun Ling, Yangtai Guan, Neng Gong, Xiaoping Tong   +17 more
wiley   +1 more source

Characterization of Rous sarcoma virus src gene products synthesized in vitro [PDF]

, 1978
Karen Beemon, Tony Hunter
openalex   +1 more source

Regulation of the Src Family Kinases by Csk

International Journal on Biological Sciences, 2012
The non-receptor tyrosine kinase Csk serves as an indispensable negative regulator of the Src family tyrosine kinases (SFKs) by specifically phosphorylating the negative regulatory site of SFKs, thereby suppressing their oncogenic potential.
M. Okada
semanticscholar   +1 more source

Progastrin Promotes Colorectal Cancer Stem Cell‐Like Properties via the Receptor PZR

Advanced Science, EarlyView.
The tumor microenvironment supports colorectal cancer (CRC) progression by maintaining cancer stem cells (CSCs) through progastrin (PG). This study identifies Protein Zero‐Related protein (PZR) as an essential receptor for PG activity, promoting CSC‐like signaling via SHP2/SRC/β‐catenin.
Julie Nguyen, Marie Lafitte, Maud Barbery, Kevin Espie, Maya Jeitany, Romain Larive, Jihane Vitre, Conception Paul, Yvan Boublik, Elise Fourgous, Valérie Simon, Audrey Sirvent, Madeline Neiveyans, Steeve Thirard, Lucile Bansard, Morgan Maillard, Nathalie Coutry, Jacques Colinge, Philippe Jay, Pierre Martineau, Michael Hahne, Julie Pannequin, Serge Roche   +22 more
wiley   +1 more source

Laboratory diagnosis of nonpolio enteroviruses: A review of the current literature

Biosafety and Health, 2023
Infections by nonpolio enteroviruses (EVs) are highly prevalent, particularly among children and neonates, where they may cause substantial morbidity and mortality.
Tarek Itani, Vladislav Chalapa, Aleksandr Semenov, Aleksandr Sergeev   +3 more
doaj  

Solvent retention capacity for different wheats and flours evaluation

Czech Journal of Food Sciences, 2012
The baking quality in the sets of both commercial and variety wheat samples (80 and 18 items) and wheat composite flour (standard and 25 blends) was evaluated in terms of the Solvent retention capacity method (AACC 56-11). Composites were prepared from a
Ivan Švec, Marie Hrušková, Jan Karas, Taťána Hofmanová   +3 more
doaj   +1 more source

In vitro translation yields a possible Rous sarcoma virus src gene product. [PDF]

, 1977
Karen Beemon, Tony Hunter
openalex   +1 more source

Targeting Glutamine Metabolism Transporter SLC25A22 Enhances CD8+ T‐Cell Function and Anti‐PD‐1 Therapy Efficacy in Cervical Squamous Cell Carcinoma: Integrated Metabolomics, Transcriptomics and T‐Cell‐Incorporated Tumor Organoid Studies

Advanced Science, EarlyView.
Through metabolomic and transcriptomic analyses, a glutamine‐enriched, immunosuppressive microenvironment is identified in cervical squamous cell carcinoma (CSCC), highlighting the glutamine transporter SLC25A22 as a key regulator of glutamine metabolism, immune checkpoint activation, and CD8+ T‐cell cytotoxicity.
Tingting Ren, Junjun Qiu, Fanghua Chen, Qian Jiang, Qinqin Liu, Tong Wu, Hua Jiang, Keqin Hua   +7 more
wiley   +1 more source

SRC hits the mark [PDF]

Nature Reviews Cancer, 2011
A new study suggests that activation of SRC may underlie multiple mechanisms of resistance to the targeted breast cancer therapy, trastuzumab.
openaire   +3 more sources