Results 171 to 180 of about 242,192 (301)

Exploration of structure–activity relationship of 2,4‐diaminopyrimidine derivatives as hematopoietic progenitor kinase 1 inhibitors

Bulletin of the Korean Chemical Society, EarlyView.
Targeting HPK1 is a promising strategy to restore T‐cell anti‐tumor immunity. We report the design and synthesis of novel 2,4‐diaminopyrimidine derivatives, focusing on systematic structure–activity relationship (SAR) analysis These findings identify key structural features for potent HPK1 inhibition, facilitating the discovery of next‐generation ...
Heechan Shin, Mi‐Ran Byun, Joon Seok Choi, Sujin Lee   +3 more
wiley   +1 more source

Lateral Josephson junctions in ballistic graphene with clean edge contact

, 2015
2
이후종
core  

Development of an AQbD-guided sustainable RP-HPLC method for simultaneous quantification of saracatinib and rapamycin in lipid-polymer hybrid nanocarriers. [PDF]

RSC Adv
Angolkar M, Paramshetti S, Patil D, K M AS, Osmani RAM, Gangadharappa HV, Fatease AA, Alamri AH, Hani U.   +8 more
europepmc   +1 more source

Nanomaterial‐based immune therapeutic strategies in neurodegenerative diseases

BMEMat, EarlyView.
This review highlights the immunomodulatory potential of nanomaterials (NMs) in treating neurodegenerative diseases (NDs). It focuses on their roles in regulating innate and adaptive immune responses to maintain immune homeostasis. By providing insights into these mechanisms, the review lays the groundwork for innovative NMs therapeutic strategies to ...
Xinru Zhou, Jia Liu, Shulin Lai, Suhan Yin, Bingmin Luo, Longquan Shao, Yiyuan Kang   +6 more
wiley   +1 more source

Search for Superconducting Proximity Effect in Nb/Graphene/Nb junction via Quantum-Hall Edge Channels

, 2015
2
이후종
core  

Study of <i>Artemisia ordosica</i> Krasch. Against Allergic Rhinitis Based on the P815 Mast Cell Degranulation Model, Network Pharmacology, Molecular Docking, and Molecular Dynamics. [PDF]

Int J Mol Sci
Wang M, Zou J, Zhang Q, Bai X, Wu S, Hu Y, Han X, Han N, Xiao B.   +8 more
europepmc   +1 more source

Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source

No Evidence of Correlation between Mutation at Codon 531 of Src and the Risk of Colon Cancer in Chinese

, 2012
[[abstract]]The protein tyrosine kinase activity of c-src proto-oncogene product, pp60c-src, is elevated in a number of human cancers, including colon cancer. Phosphorylation of human pp60c-src carboxy-terminal tyrosine 530 suppresses its kinase activity.
Wang, Nancy M. ; Yeh, Kun-Tu; Tsai, Chan-Hai; Chen, Shu-Jung; Chang, Jan-Gowth
core  

A One-Year Retrospective Study of the Occurrence of Sport-Related Concussions in Japanese University Sports: Characteristics of Athletes with Multiple Occurrences. [PDF]

Sports (Basel)
Muramoto Y, Kimura T, Kinoda A, Katsumata Y, Sato K.   +4 more
europepmc   +1 more source

Classifying avian drinking behaviour: ecological insights and implications in a changing world

Biological Reviews, EarlyView.
ABSTRACT Water is a fundamental currency of life, and its availability significantly influences animal behaviour, physiology and distributions. However, our knowledge around the dependence on water for drinking and the direct and indirect mechanisms driving related behaviours remains partial in the context of changing climates. Here, we review patterns
Shannon R. Conradie, Marc T. Freeman
wiley   +1 more source