Results 221 to 230 of about 512,141 (378)

Conformational processing of oncogenic v-Src kinase by the molecular chaperone Hsp90

open access: yesProceedings of the National Academy of Sciences of the United States of America, 2015
Edgar E. Boczek   +7 more
semanticscholar   +1 more source

Exploration of Fluorinated Pyrazolidine‐3,5‐Diones for Positron Emission Tomography Imaging of the P2Y12 Receptor in the Central Nervous System

open access: yesChemMedChem, EarlyView.
Fluorinated pyrazolidine‐3,5‐dione derivatives are developed with the aim to find a positron emission tomography (PET) tracer candidate for imaging of the P2Y12 receptor. All compounds show nanomolar affinity. One compound is radiolabeled with 18F and used in PET imaging studies, revealing rapid metabolism and limited brain uptake.
E. Johanna L. Stéen   +11 more
wiley   +1 more source

Harnessing Viral Proteases for Cellular and Molecular Engineering

open access: yesChemistry–Methods, EarlyView.
Engineered viral proteases (VIPs) provide programmable control of protein function with high specificity and low toxicity. Integrated with chemogenetic and optogenetic modules, these VIP systems enable logic gate manipulation for targeted regulation of cell signaling, gene expression, protein secretion, and degradation, thereby offering versatile ...
Mingguang Cui   +2 more
wiley   +1 more source

Direct regulation of GAS6/AXL signaling by HIF promotes renal metastasis through SRC and MET

open access: yesProceedings of the National Academy of Sciences of the United States of America, 2014
Erinn B. Rankin   +13 more
semanticscholar   +1 more source

Identification of Anoikis‐Related Subgroups and Prognosis Model in Colon Cancer

open access: yesCancer Nexus, EarlyView.
ABSTRACT Background Anoikis represents a distinct type of programmed cell death that serves a critical function in tumor development and metastatic. Despite its significance, there remains a notable gap in comprehensive studies that explore the role of Anoikis specifically within the context of colon cancer (CC). Thus, it becomes imperative to pinpoint
Shaokang Yang   +5 more
wiley   +1 more source

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