Results 221 to 230 of about 168,331 (269)

Method for generation and ex vivo expansion of genetically edited mouse Tregs. [PDF]

J Leukoc Biol
Gilad Y, Dean AM, Xia Y, Han SJ, Lonard DM, O'Malley BW.   +5 more
europepmc   +1 more source

CRISPR Enabled Precision Oncology: From Gene Editing to Tumor Microenvironment Remodeling

Med Research, EarlyView.
CRISPR technology has progressed from a prokaryotic immune system to a diverse suite of editing platforms, including Cas nucleases, base and prime editors, and RNA‐targeting enzymes. These advances enable precise genomic and epigenomic interventions, high‐throughput functional screening, and immune engineering.
Kailai Li, Peixin Huang, Yue Qian, Anqi Lin, Jingjun He, Junyi Shen, Li Chen, Kai Miao, Jian Zhang   +8 more
wiley   +1 more source

Industry-supported healthcare programme for concussion management in junior community Australian football. [PDF]

BMJ Open Sport Exerc Med
Gracias LJ, Patterson BE, Mosler AB, Savill B, Franke I, Crossley KM, Clifton P, Makdissi M, Willmott C, Shawdon A, Reyes J, King MG.   +11 more
europepmc   +1 more source

Circadian Immunity and Vascular Inflammation in Cardiovascular Disease Chronotherapy Windows: Time for a Re‐Assessment

Med Research, EarlyView.
ABSTRACT Circadian rhythms orchestrate cardiovascular physiology by regulating immune and inflammatory pathways. Disruption of these rhythms profoundly alters vascular homeostasis, thereby promoting the onset and progression of cardiovascular diseases (CVD).
Tian Zhang, Ge Zhang, Tian‐Ding Liu, Tianshu Gu, Fengyi Yu, Pengyuan Xu, Wunan Mi, Xuanjiang Zhao, Qian Guo, Honglin Zheng, Taiqi Zhao, Qiang Li, Di Lu, Mingxuan Duan, Chaoyang Yu, Ruhao Wu, Shiqian Zhang, Haonan Zhang, Zeyu Wang, Youyang Zheng, Yan Xiao, Zenglei Zhang, Ge Zhang   +22 more
wiley   +1 more source

Special Issue "Role of Molecular Dynamics Simulations and Related Methods in Drug Discovery". [PDF]

Int J Mol Sci
Liu H.
europepmc   +1 more source

The Contribution of Cholesterol and Squalene Synthase in Cancer: Molecular Mechanisms, Lipid Rafts and Therapeutic Approaches

Medicinal Research Reviews, EarlyView.
ABSTRACT A plethora of cellular signaling pathways are dysregulated in cancer cells, promoting carcinogenesis and migration. Cholesterol has recently been linked to cancer by several subcellular mechanisms, especially by its involvement in the formation of lipid rafts, which promote oncogenic signaling and cancer cell invasion. Squalene synthase (SQS),
Danai Mavridi, Theodora Katavati, Angeliki P. Kourounakis   +2 more
wiley   +1 more source

PRL-3 up-regulates exosomal ITGαvβ5 expression to promote liver pre-metastatic niche formation and colon cancer liver metastasis. [PDF]

Exp Hematol Oncol
Lan Q, Xu H, Zeng Y, Liu L, Hu X, Yang Q, Zhang Y, Liu W, Wu J, Weng J, He J, Xu X, Lai W, Chu Z.   +13 more
europepmc   +1 more source

Wasting syndrome as a predictive factor for adverse health outcomes in older adults: A prospective cohort study

Nutrition in Clinical Practice, EarlyView.
Abstract Wasting syndrome (WS), also known as unintentional weight loss, is defined as a 5% reduction in body weight over a period of 6–12 months. The mortality associated with WS in older adults has not been adequately explored. The objective of this study was to investigate this relationship in hospitalized older individuals over an 18‐month period ...
Roana Carolina Bezerra dos Santos, Cláudia Porto Sabino Pinho, Eduila Maria Couto Santos, Maria Caroline da Silva Patricio, Stefany Beatriz do Nascimento, Letícia Sabino Santos, Taynara de Sousa Rego Mendes, Alcides da Silva Diniz   +7 more
wiley   +1 more source

Exploring the potential mechanisms of anti-pulmonary fibrosis effects of Luo Han Guo via network pharmacology, molecular docking, and experimental validation. [PDF]

Sci Rep
Cui Q, Liu Y, Li Y, Li Z, Wei W, Yang S, Liu X, Chen L, Xu K, Li Y, Zhang Q, Bai J.   +11 more
europepmc   +1 more source

A new species of Drimia Jacq. ex Willd. (Asparagaceae) from Nellai wildlife sanctuary, Western Ghats, India

Nordic Journal of Botany, EarlyView.
The new species Drimia courtallensis from the Nellai Wildlife Sanctuary of Tamil Nadu, India is described and illustrated. It is similar to Drimia razii,in its necked bulb, hysteranthous nature, lax inflorescence and diurnal flowers on moderately short pedicels but it can be distinguished by its broader linear‐lanceolate leaves (230–420 × 6–15 mm ...
Arumugam Senniappan, Sukdeb Bera, Resmi Sekarathil, Karthigeyan Kaliyamurthy   +3 more
wiley   +1 more source