Results 201 to 210 of about 260,978 (272)

Exploring vaginal microbiota–tissue resident stem cell crosstalk: VCAM1/Akt signaling ‐mediated enhancement of regenerative capacity

Interdisciplinary Medicine, EarlyView.
Vaginal microbiota‐derived secretory factors enhance the regenerative capacity of human endometrial stem cells by upregulating VCAM1 and activating PI3K/Akt signaling. This microbiota–stem cell crosstalk promotes self‐renewal, migration, multilineage differentiation, and metabolic reprogramming in vitro and in vivo, establishing a novel microbiota ...
Soo‐Rim Kim, Eun‐Kyung Min, Choon‐Mi Lee, Kun‐Hee Na, Chan Hum Park, YunJae Jung, Hwa‐Yong Lee   +6 more
wiley   +1 more source

Desmoplakin Loss Leads to PKC- and Src-Mediated Contractile Dysfunction in Cardiomyocytes. [PDF]

Circ Res
Gokhan I, McKay M, Li X, Zanetti M, Granger JM, Sendek JM, Mora Pagan AJ, Campbell KS, Akar FG, Campbell SG.   +9 more
europepmc   +1 more source

Improving protein secretion with autophagy‐inhibiting or proteasome‐activating small molecules

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND Therapeutic proteins are produced frequently by mammalian cells in large‐scale bioreactors. As a result, producer cells are exposed to a chemically (nutrients, gas exchange, target protein overexpression) and physically (shear due to mixing) stressful environment, which can lead to endoplasmic reticulum (ER) stress and loss of ...
R Chauncey Splichal, Christina Chan, S Patrick Walton   +2 more
wiley   +1 more source

Fasting serum annexin A2 is associated with peripheral insulin sensitivity and may enhance glucose uptake via Src-dependent signaling. [PDF]

J Diabetes Investig
Ito Y, Okura T, Anno M, Kitao S, Endo S, Ichihara Y, Sawano T, Miake J, Ueta E, Kato M, Taniguchi SI, Yamamoto K, Imamura T.   +12 more
europepmc   +1 more source

Establishing a transdiagnostic dimension of early childhood depressive symptoms using the Preschool Feelings Checklist‐Scale

JCPP Advances, EarlyView.
Abstract Background Young child depressive symptoms are associated with various concurrent and future psychiatric problems, indicating early transdiagnostic risk for psychopathology. We now need studies that identify and test the robustness, reliability, and validity of early emerging depressive symptom dimensions, examining them relative to wide ...
Nicolas L. Camacho, Kirsten E. Gilbert, Rebecca Tillman, Joan L. Luby, Michael S. Gaffrey   +4 more
wiley   +1 more source

Antibiotic stewardship in the context of management of early onset neonatal sepsis-an evolving paradigm shift. [PDF]

World J Clin Pediatr
Kandhari A, Jagga M, Banerjee S.
europepmc   +1 more source

Community‐Based Postdoctoral Dentistry Program in Special Care Dentistry: Development and Implementation

Journal of Dental Education, EarlyView.
ABSTRACT Introduction There is a growing, national need for properly trained dentists to provide special care dentistry to a transitioning, aging, and medically complex population. This study describes the implementation and initial impact of a novel academic‐community intervention designed to rapidly address this critical gap in provider training and ...
Dan Burch, Marvellous A. Akinlotan, Oluyomi Oloruntoba, Prerana Gurudath, Carol Dean, Katherine Miller Nimmons, Nina Ray, Jayne Reuben   +7 more
wiley   +1 more source

Scleroderma Renal Crisis and Posterior Reversible Encephalopathy Syndrome Triggered by Non-steroidal Anti-inflammatory Drugs. [PDF]

Intern Med
Suzuki T, Ishikawa M, Yamaguchi T, Miyata M, Nawano T, Yokokawa Y, Kon S, Matsuki E, Watanabe S, Kamei K, Ichikawa K, Watanabe M.   +11 more
europepmc   +1 more source

Mass Spectrometry Insights Into Post‐Translational Modifications in Extracellular Vesicles

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐enclosed structures secreted by virtually all living cells, serving as essential mediators of intercellular communication in both physiological and pathological processes. There is growing interest in their potential applications as biomarkers, therapeutic targets, and drug delivery systems, which ...
Dávid Virág, Krisztián Márk Karvaly, Alexandra Molnár, Mirjam Balbisi, Júlia Németh, Lilla Turiák   +5 more
wiley   +1 more source