Results 41 to 50 of about 451,893 (254)
Quantitative Expression of C-Type Lectin Receptors in Humans and Mice [PDF]
, 2012 C-type lectin receptors, their adaptor molecules and S-type lectins (galectins) are involved in the recognition of glycosylated self-antigens and pathogens.
Akira +39 more
core +5 more sources
HEV in Blood Donors in Switzerland: The Route to Safe Blood Products
PathogensThe hepatitis E virus (HEV) is an emerging infectious disease with zoonotic potential, causing acute hepatitis in humans. Infections in healthy individuals are often acute, self-limiting and asymptomatic, thus leading to the underdiagnosis of HEV ...
Mauro Serricchio +4 more
doaj +1 more source
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source
New data strengthen the connection between Short Range Correlations and the EMC effect
, 2012 Recently published measurements of the two nucleon short range correlation ($NN$-SRC) scaling factors, $a_2(A/d)$, strengthen the previously observed correlation between the magnitude of the EMC effect measured in electron deep inelastic scattering at $0.
Hen, O., Piasetzky, E., Weinstein, L. B.
core +1 more source
Non-Clinical Benefits of Evidence - Based Veterinary Medicine [PDF]
, 2016 Clinical bottom lineThere are few studies addressing business benefits of EBVM.While the need for a wider adoption of EBVM has been highlighted and linked to commercial benefits, further empirical studies are needed to identify and quantify such linkages.
Hauser, S, Jackson, E L
core +5 more sources
Prevalence of Acute Hepatitis E Virus Infections in Swiss Blood Donors 2018–2020
VirusesIntroduction: Hepatitis E virus (HEV) genotype 3 is the major cause of acute viral hepatitis in several European countries. It is acquired mainly by ingesting contaminated pork, but has also been reported to be transmitted through blood transfusion ...
Christoph Niederhauser +6 more
doaj +1 more source
Integrated Computational Chemistry and Experimental Analysis of Fructus Ligustri to Target Chemoresistant Ovarian Cancer Cells [PDF]
Iranian Journal of Chemistry & Chemical EngineeringOvarian cancer remains a leading cause of gynecological cancer mortality due to late diagnosis and limited therapeutic options. Fructus Ligustri Lucidi (FLL), a traditional Chinese medicinal herb, exhibits multiple pharmacological activities, but its ...
Zheyun Li +3 more
doaj +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
De novo variant in tyrosine kinase SRC causes thrombocytopenia: case report of a second family
Platelets, 2019 A germline heterozygous gain-of-function p.E527K variant in tyrosine kinase SRC was previously found to cause thrombocytopenia, myelofibrosis, bleeding, bone pathologies, premature edentulism and mild facial dysmorphia in nine patients of a single ...
Lore De Kock +6 more
doaj +1 more source
Role of Src and Cortactin in Pemphigus Skin Blistering
Frontiers in Immunology, 2019 Autoantibodies against desmoglein (Dsg) 1 and Dsg3 primarily cause blister formation in the autoimmune disease pemphigus vulgaris (PV). Src was proposed to contribute to loss of keratinocyte cohesion.
Daniela Kugelmann +15 more
doaj +1 more source