Results 51 to 60 of about 454,409 (253)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Theories, techniques and strategies of sustainable circular economy: a systematic literature review

Discover Sustainability
This systematic literature review paper provides an extensive understanding of the circular economy and sustainability for the various manufacturing sectors. The papers were taken from Scopus and Google Scholar for this systematic review.
R. Purushothaman, R. Alamelu, S. Selvabaskar, M. Sudha   +3 more
doaj   +1 more source

Opposing effects of inhibitors of Aurora-A and EGFR in Autosomal Dominant Polycystic Kidney Disease (ADPKD)

Frontiers in Oncology, 2015
Aurora-A kinase (AURKA) overexpression in numerous tumors induces aneuploidy, in part because of cytokinetic defects. Alisertib and other small-molecule inhibitors targeting AURKA are effective in some patients as monotherapies or combination therapies.
Anna S Nikonova, Alexander Y Deneka, Alexander Y Deneka, Louisa eEckman, Meghan C Kopp, Harvey H Hensley, Brian L Egleston, Erica eGolemis   +7 more
doaj   +1 more source

Stylized features of single-nucleon momentum distributions

, 2015
Nuclear short-range correlations (SRC) typically manifest themselves in the tail parts of the single-nucleon momentum distributions. We propose an approximate practical method for computing those SRC contributions to the high-momentum parts.
Cosyn, Wim, Ryckebusch, Jan, Vanhalst, Maarten   +2 more
core   +1 more source

Potential impacts on ecosystem services of land use transitions to second-generation bioenergy crops in GB [PDF]

, 2015
We present the first assessment of the impact of land use change (LUC) to second-generation (2G) bioenergy crops on ecosystem services (ES) resolved spatially for Great Britain (GB).
Albaladejo, Alexander, Arima, Aylott, Barnett, Bateman, Bianchi, Blanco-Canqui, Boardman, Borzecka-Walker, Bosatta, Bourke, Busch, Börjesson, Clifton-Brown, Clifton-Brown, Coleman, Dauber, Davis, Dockerty, Dondini, Donnelly, Eigenbrod, FAO/Iiasa/ISRIC/Isscas/JRC, Fargione, Finch, Godfray, Hansen, Hastings, Hastings, Hastings, Hastings, Hillier, Holland, Kang, Lattimore, Le, Lovett, Lovett, Manning, Matthews, Metzger, Plevin, Rathmann, Rowe, Rowe, Rowe, Schulze, Searchinger, Selman, Semere, Semere, Smith, St Clair, Tallis, Tilman, Tirado, UK National Ecosystem Assessment, Updegraff, Upham, Valentine, Vanloocke, Wang, Wang, Werling, Whitaker, Wynn, Yan, Zatta, Zimmermann   +69 more
core   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Prostaglandin E2-dependent activation of Src-Stat3 signal pathway in human lung adenocarcinoma cells

Czech Journal of Food Sciences, 2004
Accumulating evidence suggests that overproduction of prostaglandin (PG) E2 attributable to induction of cyclooxygenase-2 plays an important role in the development of lung adenocarcinoma.
I. Nagamine, T. Yano, K. Endoh, T. Yamaki, T. Morimura, M. Miyahara, H. T. T. Nguyen, J. Pokorný, H. Sakurai   +8 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

ESSENTIAL ROLE OF LYN IN FIBROSIS

Frontiers in Physiology, 2016
Fibrotic disorders involve replacement of normal parenchyma with myofibroblasts, which deposit connective tissue, leading to obliteration of the function of the underlying organ.
Hung Pham, Chiara Birtolo, Chintan Chheda, Wendy Yang, Maria Rodriguez, Sandy Liu, Gabriele Gugliotta, Michael Lewis, Vincenzo Cirulli, Stephen Pandol, Andrzej Ptasznik   +10 more
doaj   +1 more source