Results 51 to 60 of about 242,192 (301)

Rhodomycin A, a novel Src-targeted compound, can suppress lung cancer cell progression via modulating Src-related pathways

, 2017
Src activation is involved in cancer progression and the interplay with EGFR. Inhibition of Src activity also represses the signalling pathways regulated by EGFR. Therefore, Src has been considered a target molecule for drug development. This study aimed
楊志新;俞松良;陳惠文, Lai, Yi-Hua;Chen, Min-Hsuan;Lin, Sih-Yin;Lin, Sheng-Yi;Wong, Yung-Hao;Yu, Sung-Liang;Chen, Huei-Wen;Yang, Chih-Hsin;Chang, Gee-Chen;Chen, Jeremy J. W.   +1 more
core   +1 more source

Selective and potent PROTAC degraders of c-Src kinase

, 2023
Using dasatinib linked to E3 ligase ligands, we identified a potent and selective dual Csk/c-Src PROTAC degrader. We then replaced dasatinib the c-Src directed ligand with a conformation-selective analog that stabilizes the aC-helix out conformation of c-
Sofia, Merajver, Peter, Ulintz, Pui Ki, Tsang, Rachel, Sexton, Matthew, Soellner, Christopher, Bingham, Nathalie, Vandecan, Daniel, Bochar, Wuxiang, Mao   +8 more
core   +1 more source

The Role of the Src Homology 3-Src Homology 2 Interface in the Regulation of Src Kinases [PDF]

Journal of Biological Chemistry, 2001
The regulatory fragment of Src kinases, comprising Src homology (SH) 3 and SH2 domains, is responsible for controlled repression of kinase activity. We have used a multidisciplinary approach involving crystallography, NMR, and isothermal titration calorimetry to study the regulatory fragment of Fyn (FynSH32) and its interaction with a physiological ...
Arold, S.T., Ulmer, T.S., Mulhern, T.D., Werner, J.M., Ladbury, J.E., Campbell, I.D., Noble, M.E.M.   +6 more
openaire   +4 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Regulation of Mint1-dependent APP trafficking by N1-Src [PDF]

, 2012
Alzheimer’s disease (AD) is a neurodegenerative disease characterised by the accumulation of Amyloid-beta (Aβ) plaques and neurofibrillary tangles. Aβ plaques form as a result of improper trafficking and processing of the Amyloid precursor protein (APP).
Black, Hannah Lucy
core  

The effect of the dual Src/Abl kinase inhibitor AZD0530 on Philadelphia positive leukaemia cell lines

, 2009
Background Imatinib mesylate, a selective inhibitor of Abl tyrosine kinase, is efficacious in treating chronic myeloid leukaemia (CML) and Ph+ acute lymphoblastic leukaemia (ALL).
Schwarz, Kerstin, Ruthardt, Martin, Romanski Annette, Romanski, Annette, Ruthardt Martin, Ottmann, Oliver G., Ottmann, Oliver G, Bacic, Biserka, Gwanmesia Patricia, Gwanmesia, Patricia Mambou, Schwarz Kerstin, Ottmann Oliver G, Bacic Biserka   +12 more
core   +1 more source

Theories, techniques and strategies of sustainable circular economy: a systematic literature review

Discover Sustainability
This systematic literature review paper provides an extensive understanding of the circular economy and sustainability for the various manufacturing sectors. The papers were taken from Scopus and Google Scholar for this systematic review.
R. Purushothaman, R. Alamelu, S. Selvabaskar, M. Sudha   +3 more
doaj   +1 more source

From nouns to verbs: How process ontologies enhance our understanding of social‐ecological systems understood as complex adaptive systems

People and Nature, 2020
Research on social‐ecological systems (SES) has highlighted their complex and adaptive character and pointed to the importance of recognizing their intertwined nature.
Tilman Hertz, Maria Mancilla Garcia, Maja Schlüter   +2 more
doaj   +1 more source

Src Inhibition Attenuates Liver Fibrosis by Preventing Hepatic Stellate Cell Activation and Decreasing Connective Tissue Growth Factor

Cells, 2020
The SRC kinase family comprises non-receptor tyrosine kinases that are ubiquitously expressed in all cell types. Although Src is reportedly activated in pulmonary and renal fibrosis, little is known regarding its role in liver fibrosis.
Hye-Young Seo, So-Hee Lee, Ji-Ha Lee, Yu Na Kang, Jae Seok Hwang, Keun-Gyu Park, Mi Kyung Kim, Byoung Kuk Jang   +7 more
doaj   +1 more source

The forgotten threat of cholera in Syria

Journal of Water and Health, 2022
Cholera is an ancient disease that persists as an issue of public health in many conflict-affected countries worldwide. Cholera is a diarrheal infection caused by ingested water or food contaminated with the bacterium Vibrio cholerae.
Orwa Al-Abdulla, Maher Alaref
doaj   +1 more source