Results 41 to 50 of about 454,409 (253)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Prevalence of Acute Hepatitis E Virus Infections in Swiss Blood Donors 2018–2020

Viruses
Introduction: Hepatitis E virus (HEV) genotype 3 is the major cause of acute viral hepatitis in several European countries. It is acquired mainly by ingesting contaminated pork, but has also been reported to be transmitted through blood transfusion ...
Christoph Niederhauser, Peter Gowland, Nadja Widmer, Soraya Amar EL Dusouqui, Maja Mattle-Greminger, Jochen Gottschalk, Beat M. Frey   +6 more
doaj   +1 more source

Integrated Computational Chemistry and Experimental Analysis of Fructus Ligustri to Target Chemoresistant Ovarian Cancer Cells [PDF]

Iranian Journal of Chemistry & Chemical Engineering
Ovarian cancer remains a leading cause of gynecological cancer mortality due to late diagnosis and limited therapeutic options. Fructus Ligustri Lucidi (FLL), a traditional Chinese medicinal herb, exhibits multiple pharmacological activities, but its ...
Zheyun Li, Lanling Ji, Xiaoyan Dai, Yongqiang Xiao   +3 more
doaj   +1 more source

New data strengthen the connection between Short Range Correlations and the EMC effect

, 2012
Recently published measurements of the two nucleon short range correlation ($NN$-SRC) scaling factors, $a_2(A/d)$, strengthen the previously observed correlation between the magnitude of the EMC effect measured in electron deep inelastic scattering at $0.
Hen, O., Piasetzky, E., Weinstein, L. B.
core   +1 more source

Sub-threshold J/ψ and ϒ production in γA collisions [PDF]

, 2019
We study sub-threshold heavy quarkonium (J/ψ and ϒ) photo-productions in γA collisions as an independent test of the universality of the nucleon-nucleon short range correlation (SRC) in nuclear scattering processes. Just below the γp threshold, the cross
Hatta, Y, Strikman, M, Xu, J, Yuan, F
core   +2 more sources

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

De novo variant in tyrosine kinase SRC causes thrombocytopenia: case report of a second family

Platelets, 2019
A germline heterozygous gain-of-function p.E527K variant in tyrosine kinase SRC was previously found to cause thrombocytopenia, myelofibrosis, bleeding, bone pathologies, premature edentulism and mild facial dysmorphia in nine patients of a single ...
Lore De Kock, Chantal Thys, Kate Downes, Daniel Duarte, Karyn Megy, Chris Van Geet, Kathleen Freson   +6 more
doaj   +1 more source

Role of Src and Cortactin in Pemphigus Skin Blistering

Frontiers in Immunology, 2019
Autoantibodies against desmoglein (Dsg) 1 and Dsg3 primarily cause blister formation in the autoimmune disease pemphigus vulgaris (PV). Src was proposed to contribute to loss of keratinocyte cohesion.
Daniela Kugelmann, Vera Rötzer, Elias Walter, Desalegn Tadesse Egu, Michael Tobias Fuchs, Franziska Vielmuth, Hilda Vargas-Robles, Michael Schnoor, Michael Hertl, Rüdiger Eming, Klemens Rottner, Klemens Rottner, Ansgar Schmidt, Volker Spindler, Volker Spindler, Jens Waschke   +15 more
doaj   +1 more source

Src Inhibition Attenuates Liver Fibrosis by Preventing Hepatic Stellate Cell Activation and Decreasing Connective Tissue Growth Factor

Cells, 2020
The SRC kinase family comprises non-receptor tyrosine kinases that are ubiquitously expressed in all cell types. Although Src is reportedly activated in pulmonary and renal fibrosis, little is known regarding its role in liver fibrosis.
Hye-Young Seo, So-Hee Lee, Ji-Ha Lee, Yu Na Kang, Jae Seok Hwang, Keun-Gyu Park, Mi Kyung Kim, Byoung Kuk Jang   +7 more
doaj   +1 more source

The forgotten threat of cholera in Syria

Journal of Water and Health, 2022
Cholera is an ancient disease that persists as an issue of public health in many conflict-affected countries worldwide. Cholera is a diarrheal infection caused by ingested water or food contaminated with the bacterium Vibrio cholerae.
Orwa Al-Abdulla, Maher Alaref
doaj   +1 more source