Targeting Src in endometriosis-associated ovarian cancer [PDF]
, 2016 The SRC proto-oncogene is commonly overexpressed or activated during cancer development. Src family kinase inhibitors are approved for the treatment of certain leukemias, and are in clinical trials for the treatment of solid tumors.
Gayther, Simon A. +13 more
core +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Experience with Selective Testing of Plasmodium Parasites in Swiss Blood Donors
PathogensTransmission of malaria by blood transfusion is rare in non-endemic countries but can lead to serious complications in blood recipients. Increasing travel to and immigration from regions at risk for tropical diseases poses a challenge to blood donation ...
Mauro Serricchio +4 more
doaj +1 more source
Assessing the Capability of Adaptive Neuro Fuzzy Interference System (ANFIS) in Estimating the Amount of Suspended Sediment Load and its Comparison with Two Models of Artificial Neutral Fuzzy Inference System Case study: Zarine rood, South east basin of Urmia Lake [PDF]
جغرافیا و توسعه, 2015 Load sediment transport in rivers is important according to their role in pollution, Reservoir filling, hydroelectric equipment life, Fish and other hydrological issues.
Alimohamad Khorshiddoost +2 more
doaj +1 more source
On the 50th anniversary of the Scientific Research Company “Electron-Carat”
Tekhnologiya i Konstruirovanie v Elektronnoi Apparature, 2022 The article is dedicated to the Scientific Research Company "Electron-Carat", which was founded in 1972 as the Lviv Research and Development Institute of Materials - the leading developer of the state-of-art materials.
Mykola Vakiv
doaj +1 more source
RNA‐related functions of BRCA2 in transcription, replication, and genome stability
FEBS Letters, EarlyView.Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda +2 more
wiley +1 more source
Sanatorium-resort complexes in the development of regional tourism
Экономика и управление, 2022 Aim. The presented study aims to build a structural model of a regional sanatorium-resort complex (SRC), to determine the role of the government and local authorities in the development of the SRC, and to formulate recommendations for the development of ...
D. A. Likhtin
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
The digital citizenship of children and adolescents: Challenges for social work education
Research in Education and Learning Innovation Archives, 2022 The digital and superdiverse societies of which we now form part require a redefinition of social work and social services to address the digital citizenship of children and adolescents.
Antonia Picornell-Lucas +1 more
doaj +1 more source