Results 21 to 30 of about 260,978 (272)

Integrated Computational Chemistry and Experimental Analysis of Fructus Ligustri to Target Chemoresistant Ovarian Cancer Cells [PDF]

Iranian Journal of Chemistry & Chemical Engineering
Ovarian cancer remains a leading cause of gynecological cancer mortality due to late diagnosis and limited therapeutic options. Fructus Ligustri Lucidi (FLL), a traditional Chinese medicinal herb, exhibits multiple pharmacological activities, but its ...
Zheyun Li, Lanling Ji, Xiaoyan Dai, Yongqiang Xiao   +3 more
doaj   +1 more source

Cbl-associated protein is tyrosine phosphorylated by c-Abl and c-Src kinases [PDF]

, 2009
Background: The c-Cbl-associated protein (CAP), also known as ponsin, localizes to focal adhesions and stress fibers and is involved in signaling events.
Tomasovic, Ana, Ana Tomasovic, Tikkanen Ritva, Fernow Inga, Inga Fernow, Siehoff-Icking, Ann, Fernow, Inga Susanne, Tikkanen, Ritva, Ann Siehoff-Icking, Tomasovic Ana, Siehoff-Icking Ann, Ritva Tikkanen   +11 more
core   +1 more source

Role of Src and Cortactin in Pemphigus Skin Blistering

Frontiers in Immunology, 2019
Autoantibodies against desmoglein (Dsg) 1 and Dsg3 primarily cause blister formation in the autoimmune disease pemphigus vulgaris (PV). Src was proposed to contribute to loss of keratinocyte cohesion.
Daniela Kugelmann, Vera Rötzer, Elias Walter, Desalegn Tadesse Egu, Michael Tobias Fuchs, Franziska Vielmuth, Hilda Vargas-Robles, Michael Schnoor, Michael Hertl, Rüdiger Eming, Klemens Rottner, Klemens Rottner, Ansgar Schmidt, Volker Spindler, Volker Spindler, Jens Waschke   +15 more
doaj   +1 more source

The effect of the dual Src/Abl kinase inhibitor AZD0530 on Philadelphia positive leukaemia cell lines [PDF]

, 2009
Background Imatinib mesylate, a selective inhibitor of Abl tyrosine kinase, is efficacious in treating chronic myeloid leukaemia (CML) and Ph+ acute lymphoblastic leukaemia (ALL).
Schwarz, Kerstin, Ruthardt, Martin, Romanski Annette, Romanski, Annette, Ruthardt Martin, Ottmann, Oliver G., Ottmann, Oliver G, Bacic, Biserka, Gwanmesia Patricia, Gwanmesia, Patricia Mambou, Schwarz Kerstin, Ottmann Oliver G, Bacic Biserka   +12 more
core   +1 more source

Selective and potent PROTAC degraders of c-Src kinase [PDF]

, 2023
Using dasatinib linked to E3 ligase ligands, we identified a potent and selective dual Csk/c-Src PROTAC degrader. We then replaced dasatinib the c-Src directed ligand with a conformation-selective analog that stabilizes the aC-helix out conformation of c-
Sofia, Merajver, Peter, Ulintz, Pui Ki, Tsang, Rachel, Sexton, Matthew, Soellner, Christopher, Bingham, Nathalie, Vandecan, Daniel, Bochar, Wuxiang, Mao   +8 more
core   +2 more sources

Opposing effects of inhibitors of Aurora-A and EGFR in Autosomal Dominant Polycystic Kidney Disease (ADPKD)

Frontiers in Oncology, 2015
Aurora-A kinase (AURKA) overexpression in numerous tumors induces aneuploidy, in part because of cytokinetic defects. Alisertib and other small-molecule inhibitors targeting AURKA are effective in some patients as monotherapies or combination therapies.
Anna S Nikonova, Alexander Y Deneka, Alexander Y Deneka, Louisa eEckman, Meghan C Kopp, Harvey H Hensley, Brian L Egleston, Erica eGolemis   +7 more
doaj   +1 more source

From nouns to verbs: How process ontologies enhance our understanding of social‐ecological systems understood as complex adaptive systems

People and Nature, 2020
Research on social‐ecological systems (SES) has highlighted their complex and adaptive character and pointed to the importance of recognizing their intertwined nature.
Tilman Hertz, Maria Mancilla Garcia, Maja Schlüter   +2 more
doaj   +1 more source

Anti-SARS-CoV-2 Antibody Development over Four Years in Blood Donors

Viruses
The blood donor population has great potential to serve as a sentinel system for the general population. The data presented in this study of a survey of the seroprevalence of Anti-SARS-CoV-2 antibodies in Switzerland are an illustrative example of this ...
Christoph Niederhauser, Nadja Widmer, Caroline Tinguely, Franziska Suter Riniker, Stefano Fontana, Andreas Buser, Sophie Waldvogel, Jutta Thierbach, Max Züger, Peter Gowland   +9 more
doaj   +1 more source

Prostaglandin E2-dependent activation of Src-Stat3 signal pathway in human lung adenocarcinoma cells

Czech Journal of Food Sciences, 2004
Accumulating evidence suggests that overproduction of prostaglandin (PG) E2 attributable to induction of cyclooxygenase-2 plays an important role in the development of lung adenocarcinoma.
I. Nagamine, T. Yano, K. Endoh, T. Yamaki, T. Morimura, M. Miyahara, H. T. T. Nguyen, J. Pokorný, H. Sakurai   +8 more
doaj   +1 more source

Technology of two-dimensional bioimpedance analysis of the human body composition

Journal of Electrical Bioimpedance, 2021
The BIA primary result sheets as a rule contain one-dimensional graphical scales with a selected area of normal values. In 1994, Piccoli et al. proposed BIVA, an alternative form of BIA data presentation, where two bioimpedance parameters are considered ...
Shchelykalina S. P., Nikolaev D. V., Kolesnikov V. A., Korostylev K. A., Starunova O. A.   +4 more
doaj   +1 more source