Results 21 to 30 of about 153,822 (251)
Frontiers in Oncology, 2015 Aurora-A kinase (AURKA) overexpression in numerous tumors induces aneuploidy, in part because of cytokinetic defects. Alisertib and other small-molecule inhibitors targeting AURKA are effective in some patients as monotherapies or combination therapies.
Anna S Nikonova +7 more
doaj +1 more source
Anti-SARS-CoV-2 Antibody Development over Four Years in Blood Donors
VirusesThe blood donor population has great potential to serve as a sentinel system for the general population. The data presented in this study of a survey of the seroprevalence of Anti-SARS-CoV-2 antibodies in Switzerland are an illustrative example of this ...
Christoph Niederhauser +9 more
doaj +1 more source
Prostaglandin E2-dependent activation of Src-Stat3 signal pathway in human lung adenocarcinoma cells
Czech Journal of Food Sciences, 2004 Accumulating evidence suggests that overproduction of prostaglandin (PG) E2 attributable to induction of cyclooxygenase-2 plays an important role in the development of lung adenocarcinoma.
I. Nagamine +8 more
doaj +1 more source
People and Nature, 2020 Research on social‐ecological systems (SES) has highlighted their complex and adaptive character and pointed to the importance of recognizing their intertwined nature.
Tilman Hertz +2 more
doaj +1 more source
ESSENTIAL ROLE OF LYN IN FIBROSIS
Frontiers in Physiology, 2016 Fibrotic disorders involve replacement of normal parenchyma with myofibroblasts, which deposit connective tissue, leading to obliteration of the function of the underlying organ.
Hung Pham +10 more
doaj +1 more source
Interplay of Matrix Stiffness and c-SRC in Hepatic Fibrosis.
Frontiers in Physiology, 2015 Introduction:In liver fibrosis activation of hepatic stellate cells (HSC) comprises phenotypical change into profibrotic and myofibroplastic cells with increased contraction and secretion of extracellular matrix (ECM) proteins.
Jan eGörtzen +11 more
doaj +1 more source
Experience with Selective Testing of Plasmodium Parasites in Swiss Blood Donors
PathogensTransmission of malaria by blood transfusion is rare in non-endemic countries but can lead to serious complications in blood recipients. Increasing travel to and immigration from regions at risk for tropical diseases poses a challenge to blood donation ...
Mauro Serricchio +4 more
doaj +1 more source
The Role of the Src Homology 3-Src Homology 2 Interface in the Regulation of Src Kinases [PDF]
Journal of Biological Chemistry, 2001 The regulatory fragment of Src kinases, comprising Src homology (SH) 3 and SH2 domains, is responsible for controlled repression of kinase activity. We have used a multidisciplinary approach involving crystallography, NMR, and isothermal titration calorimetry to study the regulatory fragment of Fyn (FynSH32) and its interaction with a physiological ...
Arold, S.T. +6 more
openaire +4 more sources
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source