Results 71 to 80 of about 512,141 (378)

Src: coordinating metabolism in cancer

Oncogene, 2022
AbstractMetabolism must be tightly regulated to fulfil the dynamic requirements of cancer cells during proliferation, migration, stemness and differentiation. Src is a node of several signals involved in many of these biological processes, and it is also an important regulator of cell metabolism.
Sara G. Pelaz, Arantxa Tabernero
openaire   +3 more sources

Matrix: a complex amalgam of structures and functions in tumor microenvironment

FEBS Open Bio, EarlyView.
The matrix is a dynamic, intricate three‐dimensional mesh of biomolecules with both structural and functional properties. This review deals with the complexity of this ‘molecular amalgam’ in the tumor microenvironment and highlights its importance in the maintenance and evolution of tumors by describing certain matrix biomolecules, such as ...
Spyros S. Skandalis, Evgenia Tsoukala, Theodora D. Sarantopoulou, Maria‐Elpida Christopoulou   +3 more
wiley   +1 more source

Assessing the Capability of Adaptive Neuro Fuzzy Interference System (ANFIS) in Estimating the Amount of Suspended Sediment Load and its Comparison with Two Models of Artificial Neutral Fuzzy Inference System Case study: Zarine rood, South east basin of Urmia Lake [PDF]

جغرافیا و توسعه, 2015
Load sediment transport in rivers is important according to their role in pollution, Reservoir filling, hydroelectric equipment life, Fish and other hydrological issues.
Alimohamad Khorshiddoost, Mehdi Feyzolahpour, Sahar Sadrafshary   +2 more
doaj   +1 more source

Src inhibition blocks renal interstitial fibroblast activation and ameliorates renal fibrosis

Kidney International, 2015
Increased Src activity has been associated with the pathogenesis of renal tumors and some glomerular diseases, but its role in renal interstitial fibrosis remains elusive.
Yanli Yan, Li Ma, Xiaoxu Zhou, M. Ponnusamy, Jinhua Tang, Michelle A. Zhuang, E. Tolbert, G. Bayliss, Jianwen Bai, S. Zhuang   +9 more
semanticscholar   +1 more source

Expression of v-src and chicken c-src in rat cells demonstrates qualitative differences between pp60v-src and pp60c-src

Cell, 1984
The retroviral oncogene v-src arose by transduction of the cellular gene c-src. The similarity between these genes raised the possibility that c-src might be able to elicit neoplastic growth. We explored this by constructing a chimeric plasmid that allows the expression of chicken c-src.
Harold E. Varmus, J. Michael Bishop, Richard C. Parker   +2 more
openaire   +3 more sources

Liver‐specific lncRNAs associated with liver cancers

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) are regulatory molecules with various functions. They are more tissue‐specific than proteins and can be used as potential biomarkers, particularly in cancer diagnostics and prognosis. In this review, we have systematically compiled all lncRNAs with exclusive expression in the human liver, verified their liver specificity ...
Olga Y. Burenina, Roman K. Makarchenko, Maria P. Rubtsova, Olga A. Dontsova   +3 more
wiley   +1 more source

Receptor tyrosine kinase and p16/CDKN2 expression in a case of tripe palms associated with non-small-cell lung cancer [PDF]

, 1999
Background: Tripe palms is a descriptive term for a cutaneous paraneoplastic keratoderma. Tripe palms are frequently associated with gastric and pulmonary carcinoma. The pathogenetic mechanism remains unknown.
Bezold, G., Dieterle, C., Greulich, K. M., Krähn, Gertraud, Peter, R. U., Wolff, H.   +5 more
core   +1 more source

Central Dysmyelination in SSADH‐Deficient Humans and Mice

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Succinic semialdehyde dehydrogenase deficiency (SSADHD) is an inherited metabolic disorder characterized by an accumulation of γ‐aminobutyric (GABA). In addition to its synaptic role as an inhibitory neurotransmitter, GABA also plays an important role in myelination.
Itay Tokatly Latzer, Henry H. C. Lee, Edward Yang, Cesar Alves, Mariarita Bertoldi, Caitlyn Fung, Spencer V. Steele, Eren Kule, Zijie Jin, Alexander Rotenberg, Jean‐Baptiste Roullet, Phillip L. Pearl   +11 more
wiley   +1 more source

Improving Sparse Representation-Based Classification Using Local Principal Component Analysis

, 2018
Sparse representation-based classification (SRC), proposed by Wright et al., seeks the sparsest decomposition of a test sample over the dictionary of training samples, with classification to the most-contributing class.
A. Singer, A.S. Georghiades, Chia-Po Wei, Christian Merkwirth, Claudio Ceruti, David L. Donoho, Hakan Cevikalp, Hongzhi Zhang, J. Wright, Jadoon Waqas, Jon Louis Bentley, Jun Yin, L Qiao, N Kambhatla, Patrice Y. Simard, R Patel, ST Roweis, Xiaoyang Tan, Y LeCun, Yong Xu, Zechao Li   +20 more
core   +1 more source

Nuclear expression of Lyn, a Src family kinase member, is associated with poor prognosis in renal cancer patients [PDF]

, 2016
Background: 8000 cases of renal cancer are diagnosed each year in the UK, with a five-year survival rate of 50 %. Treatment options are limited; a potential therapeutic target is the Src family kinases (SFKs).
Aitchison, Michael, Edwards, Joanne, Fraser, Siobhan, Hammond, Rachel, Jones, Robert J., Lim, Zhi, MacDonald, Alasdair I., Oades, Grenville M., Qayyum, Tahir, Roseweir, Antonia K.   +9 more
core   +1 more source