Results 81 to 90 of about 260,978 (272)

Experimental Study on Elastic-Plastic Behavior of SRC Columns with High Strength Steel [PDF]

, 2006
P(論文)The demand to use high strength and high performance material because of large span and high rise of building in recent years. As to use of high-strength steel in composite steel and reinforced concrete structures, it remains to be clarified whether
難波, 隆行, 仲野, 喜晴, 堺, 純一, 44485, 南, 宏一, 44484, 44486, 藤澤, 一善, 44483, 44482   +9 more
core  

Co‐Delivery of Sustained Release Chondroitinase ABC‐37 With Human iPSC‐Derived Neural Progenitors Promotes Transplant Survival and Functional Recovery in a Rodent Model of Stroke

Advanced Science, EarlyView.
A regenerative strategy for stroke combines human stem cell–derived neural progenitor cells with sustained release of a matrix‐modifying, thermostable chondroitinase ABC‐37 enzyme. In a rat model of stroke, co‐delivery enhanced transplanted cell survival and neuronal differentiation, degraded inhibitory extracellular matrix components, and improved ...
Nitzan Letko Khait, David Xinzheyang Li, Keyi Guo, Hong Cui, Quinton Sirianni, Dhana Abdo, Cindi M. Morshead, Molly S. Shoichet   +7 more
wiley   +1 more source

Transition from normal to cancerous cell by precancerous niche (PCN) induced chronic cell-matrix stress

4 open, 2019
The attempt to restore homeostasis, once disrupted, such that complex signaling, crosstalk between ubiquitous proteins, and a diverse range of pathways gone awry is near impossible, especially in the presence of an ongoing pathogenic stimuli with ...
Brücher Björn L.D.M., Jamall Ijaz S.
doaj   +1 more source

Experimental Study on Elastic-Plastic Behavior of SRC Columns with High Strength Steel [PDF]

, 2005
P(論文)The demand to use high strength and high performance material because of large span and high rise of building in recent years. As to use of high-strength steel in composite steel and reinforced concrete structures, it remains to be clarified whether
44159, 44158, 難波, 隆行, 堺, 純一, 南, 宏一, 44157, 44156, 藤澤, 一善, 44161, 藤沢, 清二, 穐田, 智佳, 44160   +11 more
core  

Src-1 and Twist1 is aberrantly up-regulated in nasopharyngeal carcinoma tissues.

, 2019
(A) the mRNA expression of Src-1 and Twist1 in tumor samples and adjacent normal tissues of the 134 NPC patients was evaluated by qRT-PCR, then relative mRNA expression Log2 (T/N) was calculated.
Jingchun Zhou (6580544), Ming Xu (151206), Zhaoyang Ke (5711612), Wei Zhang (405), Jiahao Mai (6580547), Jingjing Zhang (163589)   +5 more
core   +1 more source

Microglial Deubiquitinase OTUD7B Stabilizes STAT3 to Promote Neuroinflammation and Cognitive Decline in Alzheimer's Disease

Advanced Science, EarlyView.
. ABSTRACT Neuroinflammation driven by microglial activation is a defining feature of Alzheimer's disease (AD), yet the molecular mechanisms sustaining this proinflammatory state remain unclear. Here, we identify the deubiquitinase OTUD7B as a critical regulator of microglial activation and AD pathology.
Luyao Li, Hao Tang, Qin Yu, Yuyang Zhang, Binglu Shi, Ying Kong, Leiyu Xu, Jingjing Shao, Chenghong Hu, Lingyu She, Zhe Wang, Haiyi Chen, Aleksandr V. Samorodov, Gang Cao, Xia Zhao, Yi Wang   +15 more
wiley   +1 more source

Expression of v-src and chicken c-src in rat cells demonstrates qualitative differences between pp60v-src and pp60c-src

Cell, 1984
The retroviral oncogene v-src arose by transduction of the cellular gene c-src. The similarity between these genes raised the possibility that c-src might be able to elicit neoplastic growth. We explored this by constructing a chimeric plasmid that allows the expression of chicken c-src.
R C, Parker, H E, Varmus, J M, Bishop
openaire   +2 more sources

Src-kinase activity is required for infection.

, 2019
A549 cells were pre-treated with non-cytotoxic concentrations of the indicated Src-kinase inhibitors (PP2 [12.5 μM], SrcI-I [6.25 μM] or both) or mock-treated (DMSO carrier control) for 5 h.
Thomas McCarty (216229), Sonja Surman (185609), Ursula J. Buchholz (7252559), Xueqiao Liu (765408), Scott E. Martin (7252562), Peter L. Collins (7252565), Shirin Munir (223824), Matthias Lingemann (7134986)   +7 more
core   +1 more source

IGF-1 and PDGF-bb suppress IL-1β-induced cartilage degradation through down-regulation of NF-κB signaling: involvement of Src/PI-3K/AKT pathway. [PDF]

, 2011
Interleukin-1β (IL-1β) is a pro-inflammatory cytokine that plays a key role in the pathogenesis of osteoarthritis (OA). Growth factors (GFs) capable of antagonizing the catabolic actions of cytokines may have therapeutic potential in the treatment of OA.
Franziska Busch, Azadeh Montaseri, Jafar Soleimani Rad, Busch, Franziska, Montaseri, Azadeh, Rad, Jafar Soleimani, Mehdi Shakibaei, Ali Mobasheri, Constance Aldinger, Aldinger, Constance, Shakibaei, Mehdi, Mobasheri, Ali, Constanze Buhrmann, Buhrmann, Constanze   +13 more
core   +2 more sources

Genetic Ablation and Multi‐Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models

Advanced Science, EarlyView.
Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.
Behnam Rashidieh, Yuanhao Yang, Amanda Louise Bain, Phillip Theron, Catharina Vosloo, Sahar Keshvari, Parinaz Ahangar, Brydie Bowden, Simon M. Tria, Ben B. Wang, Sandra Isenmann, Nicholas J. Westra van Holthe, Zherui Xiong, Hani Vu, Sowmya Sharma, Asmerom Sengal, J. Alejandro Lopez, John Finnie, Antonella Papa, Pascal H.G. Duijf, Quan Nguyen, Pirjo M. Apaja, Kum Kum Khanna   +22 more
wiley   +1 more source