Results 81 to 90 of about 153,822 (251)

5-O-Methylvisammioside alleviates depression-like behaviors by inhibiting nuclear factor kappa B pathway activation via targeting SRC

Neural Regeneration Research
Preliminary studies on emerging herbal ingredients have highlighted alternative pathways that inflammation and modulate perturbed immunity as valuable strategies for treating depression.
Wenqian Zhu, Bingjin Li, Ranji Cui
doaj   +1 more source

ANXA2+ Small Extracellular Vesicles Drive Chemoresistance in Anaplastic Thyroid Cancer by Promoting XRCC5 Lactylation and Enhancing Non‐Homologous End‐Joining Repair

Advanced Science, EarlyView.
ANXA2+ sEVs promote cisplatin resistance in ATC by stabilizing the SRC/LDHA interaction, increasing LDHA phosphorylation and activity, and lactate production. Elevated lactate levels promote KAT5‐mediated lactylation of XRCC5 at lysine 265, enhancing its binding to XRCC6.
Shanshan Su, YiShan Xiong, Yuxuan Liang, Xiang Min, Daofeng Dai   +4 more
wiley   +1 more source

CCL5 enhances invasion of squamous cell carcinoma via syndecan-1-dependent ERK signaling

Cell Structure and Function
Cancer cells form clusters and invade the surrounding stroma. This phenomenon is associated with metastasis and poor prognosis in patients with cancer. Therefore, prevention of invasion may improve cancer therapy.
Toko Yamazaki, Yuji Kumagai, Kosuke Maeda, Tomoyasu Aizawa, Kosuke Maekawa, Atsushi Enomoto, Seiichiro Ishihara, Hisashi Haga   +7 more
doaj   +1 more source

The potential of Src inhibitors

Aging, 2015
The src family of kinases (SFKs), including c-Src, Fyn, Yes, Lck, Lyn, Hck, Fgr and Blk, have been widely implicated in the pathogenesis of cancer [1]. Being pleiotropic, SFKs are involved in a number of different cellular activities such as regulation of cell growth, survival, adhesion, cytoskeletal remodeling and motility.
Elias, Daniel, Ditzel, Henrik
openaire   +2 more sources

TRAF6 Lactylation in Glycolytic Macrophages Drives NF‐κB Signaling and M1 Polarization During Orthodontic Tooth Movement

Advanced Science, EarlyView.
Schematic diagram showing compressive stress triggers glycolytic reprogramming and lactate accumulation in macrophages. Lactate mediates TRAF6 lactylation at K171/K180 dual sites, which enhances its K63‐linked ubiquitination to activate the NF‑κB pathway and promote M1 polarization. This cascade drives orthodontic tooth movement (OTM) and alveolar bone
Xinyi He, Guodong Zhao, Yun Hu, Wenya Bai, Hao Tan, Shuai Yuan, Sihan Yang, Ye Zhu, Xiaohui Xu, Leilei Zheng   +9 more
wiley   +1 more source

The Shuilian Cave in the Upper Region of the Chang River (Karst of NW Yunnan, China)

Acta Carsologica, 2009
In upper reaches of the Chang (Yangtze) river, in Deqen prefecture, in northwestern part of the Yunnan province, karst is developed in Devonian carbonate rocks.
Martin Knez, Janja Kogovšek, Andrej Kranjc, Hong Liu, Metka Petrič, Tadej Slabe   +5 more
doaj   +1 more source

Enhancing Super‐Resolution Spatial Transcriptomics Data by Transfer Learning

Advanced Science, EarlyView.
SpotZoomer employs a transfer‐learning‐based strategy to enhance the resolution of Visium data by leveraging available high‐resolution priors. The resulting super‐resolved maps enable sharper delineation of cell boundaries and more precise inference of cell–cell communication patterns that would otherwise remain obscured at native resolution.
Xiaoyu Li, Lihua Zhang, Wenwen Min
wiley   +1 more source

scTIDE: Deciphering Critical Transitions Through Cell‐Perturbed Manifold Graphs and Optimal Transport Conditional Flow Matching

Advanced Science, EarlyView.
scTIDE identifies single‐cell tipping points by combining manifold‐based graph representations with optimal‐transport conditional flow matching, which preserves intrinsic topology and models distributional dynamics. It supports critical‐transition detection at individual‐cell resolution, prediction of unseen cells, and dimensionality reduction and ...
Jiayuan Zhong, Bowen Niu, Yongbo Yu, Shiyang Nie, Xuerong Gu, Pei Chen, Rui Liu   +6 more
wiley   +1 more source

Malignant progression of liver cancer progenitors requires lysine acetyltransferase 7–acetylated and cytoplasm‐translocated G protein GαS

Hepatology, EarlyView., 2022
KAT7‐acetylated and cytoplasm‐translocated G‐protein GαS enhances IL‐6 effect and drives HCC progenitor cell progression. Abstract Background and Aims Hepatocarcinogenesis goes through HCC progenitor cells (HcPCs) to fully established HCC, and the mechanisms driving the development of HcPCs are still largely unknown.
Ye Zhou, Kaiwei Jia, Suyuan Wang, Zhenyang Li, Yunhui Li, Shan Lu, Yingyun Yang, Liyuan Zhang, Mu Wang, Yue Dong, Luxin Zhang, Wannian Zhang, Nan Li, Yizhi Yu, Xuetao Cao, Jin Hou   +15 more
wiley   +1 more source

A map of community‐based obesity prevention initiatives in Australia following obesity funding 2009–2013

Australian and New Zealand Journal of Public Health, 2015
Objective: Obesity is the single biggest public health threat to developed and developing economies. In concert with healthy public policy, multi‐strategy, multi‐level community‐based initiatives appear promising in preventing obesity, with several ...
Jillian Whelan, Penny Love, Anne Romanus, Tahna Pettman, Kristy Bolton, Erin Smith, Tim Gill, John Coveney, Elizabeth Waters, Steve Allender   +9 more
doaj   +1 more source