Results 101 to 110 of about 260,978 (272)

Transcription Factor HOXC11 Drives Colorectal Cancer Progression and Metastasis via CAMK2A‐Dependent CXCL5 Upregulation

Advanced Science, EarlyView.
HOXC11 drives colorectal cancer progression by transcriptionally activating CAMK2A, which triggers NF‐κB–dependent CXCL5 upregulation. CXCL5–CXCR2 signaling further reinforces HOXC11 expression through the ERK1/2–SP1 axis, forming a prometastatic positive feedback loop that is effectively disrupted by combined CAMK2A and CXCR2 inhibition.
Qingyang Sun, Hengjie Xu, Sheng Yang, Jiahui Zhou, Chuanxin Tian, Hongxu Nie, Chi Jin, Tuo Wang, Zhihao Chen, Junwei Tang, Yifei Feng, Xiaowei Wang, Yueming Sun   +12 more
wiley   +1 more source

CCL5 enhances invasion of squamous cell carcinoma via syndecan-1-dependent ERK signaling

Cell Structure and Function
Cancer cells form clusters and invade the surrounding stroma. This phenomenon is associated with metastasis and poor prognosis in patients with cancer. Therefore, prevention of invasion may improve cancer therapy.
Toko Yamazaki, Yuji Kumagai, Kosuke Maeda, Tomoyasu Aizawa, Kosuke Maekawa, Atsushi Enomoto, Seiichiro Ishihara, Hisashi Haga   +7 more
doaj   +1 more source

Autophagic degradation of focal adhesions underlies metastatic cancer dissemination

Molecular & Cellular Oncology, 2017
Autophagy inhibition is being evaluated as a novel therapeutic strategy in multiple tumor types, but little is known about its implications for metastatic dissemination.
Marina N. Sharifi, Erin E. Mowers, Kay F. Macleod   +2 more
doaj   +1 more source

Selective Modulation of OTUB1 Noncanonical Function via a bioPhosTAC Strategy

Advanced Science, EarlyView.
This work positions the versatile performance of the peptide‐based bioPhosTAC platform for dissecting phosphorylation‐dependent biology and expanding the scope of induced‐proximity technologies. We demonstrated that selective manipulation of a tyrosine phosphorylation site is sufficient to propagate coordinated cellular consequences.
Seung Un Seo, Seon Min Woo, Minhyeong Choi, Soeun Rhee, Simmyung Yook, Donghyuk Shin, Kwang‐Su Park, Taeg Kyu Kwon   +7 more
wiley   +1 more source

The potential of Src inhibitors

Aging, 2015
The src family of kinases (SFKs), including c-Src, Fyn, Yes, Lck, Lyn, Hck, Fgr and Blk, have been widely implicated in the pathogenesis of cancer [1]. Being pleiotropic, SFKs are involved in a number of different cellular activities such as regulation of cell growth, survival, adhesion, cytoskeletal remodeling and motility.
Elias, Daniel, Ditzel, Henrik
openaire   +2 more sources

Characterization of an Engineered Src Kinase to Study Src Signaling and Biology [PDF]

, 2016
Pharmacologic inhibitors of protein kinases comprise the vast majority of approved signal transduction inhibitors for cancer treatment. An important facet of their clinical development is the identification of the key substrates critical for their driver role in cancer.
Leanna R, Gentry, Andrei V, Karginov, Klaus M, Hahn, Channing J, Der   +3 more
openaire   +2 more sources

Physical development of women in Magadan Region in age and ethnic aspects

Якутский медицинский журнал
Anthropometry is known to be a qualitative measure that reflects the level of health state of a population. For the first time, an assessment study on physical development of women in age and ethnic aspects was conducted in the territory of Magadan Region.
O. O. Alyoshina, I. V. Averyanova
doaj   +1 more source

Inorganic Nanomaterials can Promote or Inhibit Tumor Metastasis Depending on Tumor Microenvironment Composition

Advanced Science, EarlyView.
As engineered nanomaterials gain prominence in cancer imaging and therapy, understanding their impact on tumor progression becomes increasingly critical. We demonstrate that gold and silica‐coated gold nanomaterials can either suppress or enhance breast cancer metastasis through distinct tumor microenvironment interactions, while identifying ...
Kiana Buttiens, Xiaoqi Zheng, Xueqi Fan, Mukaddes Izci, Christy Maksoudian, Irati Perez Gilabert, Tianjiao Chu, Filipa Goncalves, Jonas Dehairs, Johan Swinnen, Bella B. Manshian, Stefaan J. Soenen   +11 more
wiley   +1 more source

SRC and STAT Pathways [PDF]

Journal of Thoracic Oncology, 2006
Members of the Src family of protein tyrosine kinases (SRC) can link signaling initiated by growth factor, integrin, and cytokine receptors on the surface of cells to their downstream effector signaling cascades (Figure 1).1 Each protein consists of an amino-terminal domain that can be myristoylated, an SH2 and SH3 domain, a tyrosine kinase domain, and
openaire   +2 more sources

Defect‐Engineered BiO2‐X Nanosheets Mediate Sono‐Thermomechanical ECM Remodeling for Hepatocellular Carcinoma Immunotherapy

Advanced Science, EarlyView.
Herein, an ultrasound‐responsive BiO2‐X/siFn1 nanoplatform is developed to overcome anti‐PD‐1 resistance in hepatocellular carcinoma. Upon ultrasound irradiation, the platform downregulates fibronectin expression, while its sonothermal effect softens the dense extracellular matrix and activates antitumor immunity in the tumor microenvironment, thereby ...
Huimin Tian, Shen Zhang, Bolin Wu, Yichi Chen, Haitao Shang, Haoyan Tan, Chunyue Wang, Weichen Xu, Huixiong Xu, Haohao Yin, Wen Cheng   +10 more
wiley   +1 more source