Results 81 to 90 of about 512,141 (378)
SH3P2 in complex with Cbl and Src [PDF]
FEBS Letters, 2004 In this report, we describe SH3P2, an SH3‐domain containing protein, as a novel Cbl‐interacting molecule that is a substrate of tyrosine kinase Src. We identified a specific polyproline motif of Cbl responsible for binding of SH3P2 and Src, and observed mutual sequestration of Src and SH3P2 from monomer Cbl molecules.
Olivier Destaing +5 more
openaire +4 more sources
LIN28B Promotes Cancer Cell Dissemination and Angiogenesis
Advanced Biology, EarlyView.Children diagnosed with high‐risk neuroblastoma have a 5‐year event‐free survival rate of less than 50% and poor outcomes after recurrence. Deregulation of the LIN28B oncogene can be addressed in these patients. Upregulation of LIN28B is shown to support the metastatic cascade.
Diana Corallo +8 more
wiley +1 more source
De novo variant in tyrosine kinase SRC causes thrombocytopenia: case report of a second family
Platelets, 2019 A germline heterozygous gain-of-function p.E527K variant in tyrosine kinase SRC was previously found to cause thrombocytopenia, myelofibrosis, bleeding, bone pathologies, premature edentulism and mild facial dysmorphia in nine patients of a single ...
Lore De Kock +6 more
doaj +1 more source
Water temperature as a natural tracer – a case study of the Malenščica karst spring (SW Slovenia)
Geologia Croatica, 2010 For the adequate protection of karst springs it is important to understand the functioning of karst systems in their recharge areas. Besides tracer tests with artificial tracers, tracings with natural tracers, such as temperature, are a very useful ...
Metka Petrič, Janja Kogovšek
doaj +1 more source
c-Src drives intestinal regeneration and transformation [PDF]
, 2014 The non‐receptor tyrosine kinase c‐Src, hereafter referred to as Src, is overexpressed or activated in multiple human malignancies. There has been much speculation about the functional role of Src in colorectal cancer (CRC), with Src amplification and ...
Cordero, Julia B. +7 more
core +3 more sources
c-src structure in human cancers with elevated pp60c-src activity [PDF]
British Journal of Cancer, 1991 We used RNAase protection and restriction fragment length polymorphism assays to detect activating mutations of c-src in a spectrum of human tumours. No mutations were detected at codons 98, 381, 444, and 530. We conclude that mutational activation is not the mechanism of enhancement of pp60c-src-specific kinase activity found in a number of human ...
B Johnson +5 more
openaire +3 more sources
Advanced Biology, EarlyView.In vitro cancer models are advantageous for studying important processes such as tumorigenesis, cancer growth, invasion, and metastasis. The complexity and biological relevance increase depending on the model structure, organization, and composition of materials and cells.
Kyndra S. Higgins +2 more
wiley +1 more source
Cells, 2020 The SRC kinase family comprises non-receptor tyrosine kinases that are ubiquitously expressed in all cell types. Although Src is reportedly activated in pulmonary and renal fibrosis, little is known regarding its role in liver fibrosis.
Hye-Young Seo +7 more
doaj +1 more source
Intersection Between Local Anesthetics and Cancer Biology: What Now? Where Are We Going?
Advanced Biology, EarlyView.Local anesthetics (LAs), widely used in anesthesia, may also play a role in cancer treatment by inhibiting tumor growth, reducing metastasis, and enhancing immune responses. They modulate key pathways like AKT/mTOR and RAS/ERK while affecting angiogenesis and tumor innervation and the immune response.
Eduardo Nunez‐Rodriguez +3 more
wiley +1 more source