Results 141 to 150 of about 64,838 (284)

The β integrin modulates serotonin sensitivity via NPxY motifs to regulate egg laying and mechanosensation behaviors in Caenorhabditis elegans

Developmental Dynamics, EarlyView.
Abstract Background Integrin is an αβ heterodimeric receptor to the extracellular matrix; its binding to the matrix recruits focal adhesions to two NPxY motifs, the tyrosine phosphorylation sites in the cytoplasmic domain. Studies found that replacing tyrosines (Y) with phenylalanines (F) in the motif of β1 integrin displayed little developmental or ...
Josh Haram Bumm, Daniel Dogeon Lee, Zhongqiang Qiu, Angela Haeun Choi, Meghana Kolluri, Michael J. Olsen, Lianzijun Wang, Myeongwoo Lee   +7 more
wiley   +1 more source

Dna-synthesis Induced By Some But Not All Growth-factors Requires Src Family Protein-tyrosine Kinases

, 1995
The Src family of protein tyrosine kinases have been implicated in the response of cells to several ligands. These include platelet-derived growth factor (PDGF), epidermal growth factor (EGF), and colony stimulating factor type 1 (CSF-1, in macrophages ...
M. F. ROUSSEL, S. A. COURTNEIDGE, BARONE, MARIA VITTORIA, S. ROCHE, M. KOEGL   +4 more
core  

Commonalities of platelet dysfunction in heart failure with preserved ejection fraction and underlying comorbidities

ESC Heart Failure, Volume 12, Issue 2, Page 1013-1028, April 2025.
Abstract Heart failure with preserved ejection fraction (HFpEF) is characterized by a lack of a specific targeted treatment and a complex, partially unexplored pathophysiology. Common comorbidities associated with HFpEF are hypertension, atrial fibrillation, obesity and diabetes.
Giorgia D'Italia, Blanche Schroen, Judith M.E.M. Cosemans   +2 more
wiley   +1 more source

EGFR-to-Src family tyrosine kinase switching in proliferating-DTP TNBC cells creates a hyperphosphorylation-dependent vulnerability to EGFR TKI

Cancer Cell International
Triple-Negative Breast Cancer (TNBC) is the most aggressive type of breast malignancy, with chemotherapy as the only mainstay treatment. TNBC patients have the worst prognoses as a large fraction of them do not achieve complete pathological response post-
Nazia Chaudhary, Bhagya Shree Choudhary, Anusha Shivashankar, Subhakankha Manna, Khyati Ved, Shagufa Shaikh, Sonal Khanna, Jeetnet Baar, Jagruti Dani, Sarthak Sahoo, R. Soundharya, Mohit Kumar Jolly, Nandini Verma   +12 more
doaj   +1 more source

Src and Syk kinases: key regulators of phagocytic cell activation.

, 2005
Src-family kinases and Syk tyrosine kinases have crucial roles in multiple leukocyte intracellular signaling pathways. In immunoreceptor-related pathways, these enzymes work together sequentially, with Src-family kinases phosphorylating specific protein ...
BERTON, Giorgio, Attila Mócsai, Giorgio Berton, ATTILA MCSAI, CLIFFORD A. LOWELL   +4 more
core   +1 more source

THE ROLE OF SRC FAMILY TYROSINE KINASES IN BCR-ABL SIGNAL TRANSDUCTION AND CHRONIC MYELOGENOUS LEUKEMIA [PDF]

, 2004
The hallmark of chronic myelogenous leukemia (CML) is the Philadelphia chromosome, which arises from the reciprocal translocation of the c-abl proto-onogene on chromosome 9 and the bcr locus on chromosome 22.
Wilson, Matthew Brian
core  

Inhibition of Src family kinases improves cognitive function after intraventricular hemorrhage or intraventricular thrombin

, 2017
Intraventricular hemorrhage causes spatial memory loss, but the mechanism remains unknown. Our recent studies demonstrated that traumatic brain injury activates Src family kinases, which cause spatial memory loss.
Waldau, Ben, Stamova, Boryana, Da Zhi Liu, Bradley P Ander, Bruce G Lyeth, Frank R Sharp, Ander, Bradley P, Jickling, Glen C, Xinhua Zhan, Lyeth, Bruce G, Liu, Da Zhi, Glen C Jickling, Boryana Stamova, Ben Waldau, Sharp, Frank R, Zhan, Xinhua   +15 more
core   +1 more source

ArtinM Cytotoxicity in B Cells Derived from Non-Hodgkin's Lymphoma Depends on Syk and Src Family Kinases. [PDF]

Int J Mol Sci, 2023
Barboza BR, Thomaz SMO, Junior AC, Espreafico EM, Miyamoto JG, Tashima AK, Camacho MF, Zelanis A, Roque-Barreira MC, da Silva TA.   +9 more
europepmc   +1 more source

Post‐Translational Modifications of Key Proteins in Hematologic Malignancies: Carcinogenic Mechanisms, Biomarker Potential, and New Therapeutic Strategies

iLABMED, EarlyView.
This article reviews the pivotal role of post‐translational modifications of proteins in the development and progression of hematologic malignancies, and explores their clinical translation potential as novel biomarkers and therapeutic targets. ABSTRACT Post‐translational modifications (PTMs) of proteins have emerged as critical regulators in the ...
Yuxuan Han, Chaowei Zhang, Weiyi Yao, Qing Hong, Xinyu Tang, Yanan Zhu, Na Chen   +6 more
wiley   +1 more source

c-Kit Receptor Maintains Sensory Axon Innervation of the Skin through Src Family Kinases. [PDF]

J Neurosci, 2022
Tuttle AM, Pomaville MB, Delgado KC, Wright KM, Nechiporuk AV.   +4 more
europepmc   +1 more source