A Distinct Mechanism to Achieve Efficient Signal Recognition Particle (SRP)–SRP Receptor Interaction by the Chloroplast SRP Pathway [PDF]
Molecular Biology of the Cell, 2009 Cotranslational protein targeting by the signal recognition particle (SRP) requires the SRP RNA, which accelerates the interaction between the SRP and SRP receptor 200-fold. This otherwise universally conserved SRP RNA is missing in the chloroplast SRP (cpSRP) pathway.
Jaru-Ampornpan, Peera +2 more
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Kinship in the SRP RNA family [PDF]
RNA Biology, 2009 The signal recognition particle (SRP) is a ribonucleoprotein complex which participates in the targeting of protein to cellular membranes. The RNA component of the SRP has been found in all domains of life, but the size of the molecule and the number of RNA secondary structure elements vary considerably between the different phylogenetic groups.
Magnus Alm, Rosenblad +3 more
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Biogenesis of the Signal Recognition Particle (Srp) Involves Import of Srp Proteins into the Nucleolus, Assembly with the Srp-Rna, and Xpo1p-Mediated Export [PDF]
The Journal of Cell Biology, 2001 The signal recognition particle (SRP) targets nascent secretory proteins to the ER, but how and where the SRP assembles is largely unknown. Here we analyze the biogenesis of yeast SRP, which consists of an RNA molecule (scR1) and six proteins, by localizing all its components.
H, Grosshans +3 more
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Mammalian SRP receptor switches the Sec61 translocase from Sec62 to SRP-dependent translocation [PDF]
Nature Communications, 2015 AbstractTwo distinct pathways deliver secretory proteins to the Sec61 protein translocase in the endoplasmic reticulum membrane. The canonical pathway requires the signal recognition particle (SRP) and its cognate receptor (SR), and targets ribosome-associated proteins to the Sec translocase.
Bhalchandra Jadhav +5 more
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Molecular Crosstalk between the Nucleotide Specificity Determinant of the SRP GTPase and the SRP Receptor [PDF]
Biochemistry, 2005 In signal recognition particle (SRP)-dependent targeting of proteins to the bacterial plasma membrane, two GTPases, Ffh (the SRP GTPase) and FtsY (the receptor GTPase), form a complex in which both proteins reciprocally stimulate each other's GTPase activities.
Shan, Shu-ou, Walter, Peter
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Conformational changes in the bacterial SRP receptor FtsY upon binding of guanine nucleotides and SRP [PDF]
Journal of Molecular Biology, 2000 In cotranslational preprotein targeting in Escherichia coli, the signal recognition particle (SRP) binds to the signal peptide emerging from the ribosome and, subsequently, interacts with the signal recognition particle receptor, FtsY, at the plasma membrane. Both FtsY and the protein moiety of the signal recognition particle, Ffh, are GTPases, and GTP
Jagath, J., Rodnina, M., Wintermeyer, W.
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SRP Workshop on 'Communication of Radiation Risk in the Modern World' [PDF]
, 2020 Communicating radiation risk is an important part of radiation protection. However, achieving effective risk communication is challenging given the negative public perception of radiation and conflicting views presented by both media and social media ...
Yoshida, H +13 more
core +1 more source
The use of diode lasers in non-surgical therapy of periodontitis
Journal of Pre-Clinical and Clinical Research, 2020 Introduction Periodontitis is a disease of multifactorial etiology and complex clinical manifestation. Removal of subgingival bacterial biofilm is a fundamental procedure in the treatment of periodontitis.
Małgorzata Majka Kulińska - Michalska +4 more
doaj +1 more source
Noncanonical Functions and Cellular Dynamics of the Mammalian Signal Recognition Particle Components
Frontiers in Molecular Biosciences, 2021 The signal recognition particle (SRP) is a ribonucleoprotein complex fundamental for co-translational delivery of proteins to their proper membrane localization and secretory pathways.
Camilla Faoro, Sandro F. Ataide
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Эндодонтия Today, 2020 Aim of the study was to evaluate the clinical efficacy of a nanomatrix with Miramistin based on M-Chip (Double White, Russia), which is used subgingivally as an addition to SRP (scaling and root planing) as a combination therapy in patients with chronic ...
Yu. A. Bakaev +3 more
doaj +1 more source