Results 121 to 130 of about 53,634 (224)
RAD51 and RAD51 paralog inhibition sensitizes nonreplicating quiescent keratinocytes to UV radiation
Photochemistry and Photobiology, EarlyView.UV radiation and other compounds generate DNA adducts that block transcription and induce cell death if not removed by the nucleotide excision repair system. In this work, we used a small‐scale pharmacological screen to discover that inhibition of the recombinase RAD51 sensitized nonreplicating quiescent keratinocytes to both UVR and other agents that ...
Saman Khan +3 more
wiley +1 more source
Advances in large DNA fragment assembly for microbial cell factory engineering
Quantitative Biology, Volume 14, Issue 3, September 2026.Abstract The efficient, rapid, and reliable assembly of DNA fragments is essential for advancing metabolic engineering and synthetic biology. With the rapid advancement of DNA synthesis and assembly technologies, the scale of DNA assembly has expanded from single genes to metabolic pathways and even genomes.
Yu Zhang +5 more
wiley +1 more source
Technologies for engineering repetitive DNA
Quantitative Biology, Volume 14, Issue 3, September 2026.Abstract Repetitive DNA, a fundamental architectural element of genomes, is widespread across organisms and comprises about 54% of the human genome. With advances in long‐read sequencing and bioinformatics approaches, highly repetitive sequences can now be characterized in depth.
Shuting Ma, Yali Cui, Yi Wu
wiley +1 more source
Humic Acids and EDTA Added to Marine Sediments Improve eDNA Detectability
Environmental DNA, Volume 8, Issue 4, July‐August 2026.Environmental DNA detectability in sediments increased with the addition of humic acid sodium salts prior to lysis. The addition of EDTA before lysis yielded a similar improvement, suggesting that various chelating agents can enhance eDNA recovery and detection. ABSTRACT Sediments are complex and challenging matrices for DNA detections.
Laury‐Ann Dumoulin +2 more
wiley +1 more source
RPA-ssDNA co-phase separation facilitates RAD51 enrichment during homologous recombination. [PDF]
Nucleic Acids ResLi Y +13 more
europepmc +1 more source
PKMYT1 in Cancer: Beyond Cell Cycle Checkpoints to Context‐Dependent Therapeutic Vulnerability
Genes, Chromosomes and Cancer, Volume 65, Issue 7, July 2026.ABSTRACT PKMYT1 has emerged as a promising therapeutic target distinguished by its tumor‐selective expression and essential role in replication stress management. Unlike WEE1, PKMYT1 is dispensable in normal cell cycles but critical for cancer cells coping with DNA damage, establishing a broad therapeutic window.
Lingxi Li +5 more
wiley +1 more source
Glia, Volume 74, Issue 7, July 2026.SNPs in SH3RF3 decrease the age of onset of Alzheimer's disease (AD). Reduced SH3RF3 blunts human microglial JNK and NFkB signaling and downstream inflammatory cytokine production, which may partially explain how SH3RF3 SNPs protect against AD. ABSTRACT Understanding how high‐risk individuals are protected from Alzheimer's disease (AD) may illuminate ...
Ronak Patel +13 more
wiley +1 more source
Target RNA-triggered CRISPR-Cas12a2 preferentially cleaves collateral DNA over RNA. [PDF]
Nucleic Acids ResKunwar S +7 more
europepmc +1 more source
Brain Pathology, Volume 36, Issue 4, July 2026.A single amino acid change (L108I) combined with PrP overexpression drives spontaneous atypical prion formation in mice, enabling also efficient propagation of diverse prion strains. This model allows studying how spontaneous prion diseases arise and provides powerful tools for investigating strain emergence, transmission barriers, and mechanisms ...
Hasier Eraña +20 more
wiley +1 more source