Results 121 to 130 of about 66,303 (280)
Advanced Science, EarlyView.Phase separation of SF3B1 acts as a key regulatory mechanism for dynamic alternative splicing throughout early mouse embryogenesis. Its absence triggers extensive splicing errors, which induce persistent DNA damage, defective cell cycle progression, and failed cell lineage commitment, and ultimately hinder the normal growth and development of ...
Kang Zhao +15 more
wiley +1 more source
Angewandte Chemie, EarlyView.Modified 2’‐deoxy‐7‐deazaadenosine bearing a chlorohexyl moiety and 2’‐deoxycytidine nucleotides bearing biotin were used in the enzymatic synthesis of dually modified dsDNAs that served as scaffolds for display of halotag and monomeric streptavidin proteins.
Giammarco Liuni +4 more
wiley +2 more sources
Schematic diagram of the amphipathic nature of ssDNA.
, 2013 (A) Amphipathic structure of ssDNA indicating the hydrophobic and the hydrophilic faces; (B) - Effect of spermidine concentration on the ssDNA mediated flotation of sphalerite; (C) - Effect of depurination of DNA on the flotation of sphalerite a - dsDNA;
Balasubramanian Vasanthakumar (317068) +2 more
core +1 more source
Advanced Science, EarlyView.This study characterizes MfAgo, an enzyme exhibiting highly efficient DNA‐guided DNA and RNA cleavage capability. Precise RNA cleavage strictly requires dimerization to stabilize the PIWI‐loop region, while its robust DNA cleavage functions in a dimerization‐independent manner.
Fuyong Huang +9 more
wiley +1 more source
Mechanical Signatures of Nucleic Acid Trefoil Knot Topology
Angewandte Chemie, EarlyView.Single‐stranded DNA can be designed with sequences that self‐thread into topological knots. The exact same sequence can alternatively be turned into an unknotted pseudoknot. The topology of the resulting polymer is determined by applying force with optical tweezers, causing the pseudoknot to resolve but the knot to tighten.
David t.R. Bakker +2 more
wiley +2 more sources
Engineered Transformer Base Editor with Enhanced Editing Efficiency
Advanced Science, EarlyView.A highly efficient transformer base editor system achieves robust genomic editing in a humanized mouse model. This work establishes a versatile and translatable platform, opening new avenues for precision gene therapy. ABSTRACT Canonical cytosine base editors (CBEs) achieve precise C‐to‐T conversions without inducing DNA double‐strand breaks (DSBs ...
Bowen Chen +5 more
wiley +1 more source
Advances in Aptamer Drug Delivery Systems for Treatment of Glioblastoma
Advanced Science, EarlyView.Aptamers have remarkable recognition capacity which is suitable for assisting drug delivery for GB. This review demonstrates that aptamers have great potential as targeted therapeutic carriers, conjugated to various therapeutic carriers, using a range of conjugation strategies and chemistries.
Alexandra R. Paul +4 more
wiley +1 more source
Angewandte Chemie, EarlyView.PQB‐4, a fluorescent small‐molecule ligand that targets c‐MYC DNA G‐quadruplexes (G4s), showed marked synergy with gemcitabine in resistant PANC‐1 cells (CI = 0.027). In vivo, the ligand reduced tumor weight by 44% in a PANC‐1 xenograft model. These results highlight the therapeutic potential of c‐MYC DNA G4‐targeting ligands for treating gemcitabine ...
Bo‐Xin Zheng +10 more
wiley +2 more sources
Insights into the world of ssDNA viruses [PDF]
VirusDisease, 2019 V. G. Malathi, Indranil Dasgupta
openaire +2 more sources
Interactions of TipαN25 and ssDNA.
, 2012 ITC experiments of Tipα with 20 nt (A), 40 nt (B), and 60 nt (C) oligomeric ssDNA. Autodock simulated model of Tipα binding an ideal ssDNA-d (GCGCG) through the dimer interface (D, E) with hydrogen bonds and salt bridges between Tipα and ssDNA (F).
Da-Cheng Wang (147804) +5 more
core +1 more source