Results 151 to 160 of about 53,752 (247)

Nonviral Gold Nanoparticle‐Mediated Delivery of CRISPR‐Cas9 Ribonucleoprotein and Long DNA Transgenes Into Primary Blood Cells

Advanced NanoBiomed Research, Volume 6, Issue 8, August 2026.
CRISPR/Cas9 has revolutionized the field of gene therapy, but delivery remains an outstanding issue. We propose a nonviral gold‐nanoparticle platform for co‐delivery of CRISPR/Cas9 ribonucleoprotein and long 2.1 kilobase dsDNA transgene constructs. This CRISPR‐AuNP is inexpensive to produce and mediate gene editing and DNA delivery in T cells and CD34+
Rachel A. Cunningham, Karthikeya S. V. Gottimukkala, Daniel D. Lane, Katrina Poljakov, Patricia Lipson, Mark R. Enstrom, Alessandro Rizzi, Aude G. Chapuis, Jennifer E. Adair   +8 more
wiley   +1 more source

Development and Optimization of CRISPR/Cas9-Assisted Recombineering in <i>Escherichia albertii</i>. [PDF]

MicroPubl Biol
Khan SA, Miller TM, Bhatt S, Li E.
europepmc   +1 more source

Mechanisms That Govern Recombinase Fidelity Control During Eukaryotic Homologous Recombination

BioEssays, Volume 48, Issue 8, August 2026.
The rate of recombinase filament formation controls the fidelity of the homologous recombination reaction by either restricting the length of strand pairing for high‐fidelity repair or increasing the length of strand pairing for more complex outcomes.
Ilayda Korkmaz, J. Brooks Crickard
wiley   +1 more source

Single-stranded DNA in the bone microenvironment promotes prostate cancer bone metastasis via the ITGA6-FAK pathway. [PDF]

Commun Biol
Chen X, Ye MS, Peng ZL, Yan F, Xiao Y, Li YJ, Xiao Y.   +6 more
europepmc   +1 more source

Deep Mutational Scanning for the Study and Engineering of Protein Assemblies

Chemistry–Methods, Volume 6, Issue 8, August 2026.
This review explores how deep mutational scanning (DMS) can be used to improve understanding and accelerate engineering of protein assemblies, from natural fibers to engineered nanocages. We discuss various types of protein assemblies and their characterization, provide an introduction to the DMS technique, and then highlight examples in which DMS has ...
Jenna B. Wolfanger, Shoili Banerjee, Carolyn E. Mills   +2 more
wiley   +1 more source

Aptamer-Functionalized SWCNT Optical Sensors for Selective and Robust Dopamine Detection in Physiological Media. [PDF]

ACS Appl Nano Mater
Stefoni MC, Yafai H, Ryan AK, Israel A, Williams RM.   +4 more
europepmc   +1 more source

Brain‐Wide Mapping and Synaptic Localization of C1QL3 Using a Novel Epitope‐Tagged Knock‐In Mouse

Journal of Comparative Neurology, Volume 534, Issue 8, August 2026.
C1QL3 is a secreted adhesion molecule that acts as a key regulator of synaptic structure and function. We generated and validated a novel epitope‐tagged knock‐in mouse line (C1ql32HA) in which two hemagglutinin (HA) epitopes were inserted near the N‐terminus of the endogenous C1QL3 protein.
William P. Armstrong IV, James M. Salvatore, Matthew J. Sticco, Keaven Caro, J. Wesley Maddox, Angie Huang, Brenna C. McAllister, Christopher B. O'Connell, Siu‐Pok Yee, Amy Lee, Susanne Ressl, David C. Martinelli, Alexander C. Jackson   +12 more
wiley   +1 more source

Structural insight into how RAD51 paralog exchange regulates RAD51 filament formation. [PDF]

Nat Struct Mol Biol
Rawal Y, Kwon Y, Jia L, Ruben EA, Ji JH, Guo L, Stratton CM, Nayak D, Tovar M, Fang Q, Jamalruddin MA, Zhou S, Kuppa S, Syed S, Jasper AM, Katz JN, Rogers CM, Kaur H, Samentar L, Zhao W, Dray E, Zhang F, Stoilova-McPhie S, Taylor AB, Burma S, Rao MK, Libich DS, Hromas R, Mazin AV, Jasin M, Zhou D, Bernstein KA, Greene EC, Wasmuth EV, Sung P, Olsen SK.   +35 more
europepmc   +1 more source

Dynamics of Heparin Translocations Through Solid‐State Nanopores

ELECTROPHORESIS, Volume 47, Issue 8, Page 799-808, August 2026.
Carbohydrates can be detected with solid‐state nanopores, but their kinetics of voltage‐driven passage are fast. To better understand the dynamics of passage of these biomolecules and the role of electrophoresis and electroosmosis, we studied the translocation characteristics of heparin as a function of salt concentration, pH and voltage polarity ...
Kexin Zhao, Matthew Waugh, Kyle Briggs, Mohammad P. Jamshidi, Janelle Sauvageau, Vincent Tabard‐Cossa   +5 more
wiley   +1 more source

A Magnetic-Assisted CRISPR-Cas12a Biosensor Incorporating a Y-DNA Probe for Sensitive Detection of <i>Schistosoma japonicum</i> Eggs. [PDF]

Biosensors (Basel)
Liu T, Guo H, Yu M, Peng J, Guan L, Xie S, Hao X, Yang Y.   +7 more
europepmc   +1 more source