Results 171 to 180 of about 53,752 (247)

Molecular recognition and induced dimerization of hnRNP A2/B1 truncations by G-quadruplex single strand DNA. [PDF]

Sci Rep
Shahatibieke D, Tang X, Zheng X, Liu Y, Abula A.   +4 more
europepmc   +1 more source

A Safe and Effective Bivalent Vaccine Candidate Against Duck Enteritis Virus and Duck‐Origin Novel Goose Parvovirus

Microbial Biotechnology, Volume 19, Issue 8, August 2026.
NGPV VP2 is expressed made DEV as vector and experessed NGPV VP2 could form virus‐like particles. rNGPV VP2‐Cre could facilitate clearance of NGPV and provided strong protection against highly virulent DEV. ABSTRACT Since 2015, duck‐origin novel goose parvovirus (NGPV) has caused severe economic losses to the Chinese duck industry, with no licensed ...
Liu Chen, Jionggang Hua, Weicheng Ye, Cun Zhang, Xinjin Li, Yinchu Zhu, Yuan Fu, Liang He, Suxin Huo, Zongxiao Wang, Zhuanli Wu, Tao Yun   +11 more
wiley   +1 more source

A genetic manipulation tool based on the GP35 recombinase for targeted gene editing in mycoplasmas of ruminants. [PDF]

J Biol Chem
Lan S, Li Z, Jing T, Cui W, Zhang Y, Hao H, Chen R, Baz AA, Tian X, Askar H, Li B, Yan X, Gao P, Chen S, Chu Y.   +14 more
europepmc   +1 more source

The Toll‐Like Receptor Signalling Pathway Is Altered in iPSC‐Derived Cortical Networks From People With Bipolar Disorder

Bipolar Disorders, Volume 28, Issue 5, August 2026.
ABSTRACT Background Induced pluripotent stem cell (iPSC)‐derived brain cells are widely utilised as in vitro models for several neuropsychiatric disorders, as they retain the donor's genetic profile, offering a unique opportunity to study living human brain cells and perform controlled experimental manipulations.
Bruna Panizzutti, Chiara Cristina Bortolasci, Megan Ellis, Briana Spolding, Courtney Swinton, Trang T. T. Truong, Cassie Field, Zoe Shih‐Jung Liu, Damián Hernández, Greg Roebuck, Ajeet B. Singh, Bruno Agustini, Robson Zazula, Ana C. Andreazza, Dana El Soufi El Sabbagh, Hyunjin Jeong, Olivia M. Dean, Jee Hyun Kim, Michael Berk, Ken Walder   +19 more
wiley   +1 more source

Replication protein A protects lagging strand gaps, restricting PARP inhibitor-induced synthetic lethality in BRCA1-deficient tumors. [PDF]

Nucleic Acids Res
VanderVere-Carozza PS, Jordan MR, Garrett JE, Pollok KE, Pawelczak KS, Turchi JJ.   +5 more
europepmc   +1 more source

Recent Advances in Conjugation Chemistry Expanding the Applications of the DNA Tetrahedron

Chemical Biology &Drug Design, Volume 108, Issue 2, August 2026.
The tetrahedral DNA nanostructure (TDN) is a promising drug delivery and biosensing platform that can be chemically modified with absolute payload precision. This review highlights explicit conjugation chemistries driving functionalization of the TDN for a broad range of applications, advancing its role in support of next‐generation biomimetic ...
Tyler J. Rutherford, Christopher J. Wilds   +1 more
wiley   +1 more source

DNA‐mimic for Specific Surface Functionalization of Zr‐MOFs for Bacterial Targeting

Angewandte Chemie, Volume 138, Issue 30, 20 July 2026.
We introduce phosphotyrosine‐modified PNA as a superior, single‐step post‐synthesis surface coating for PCN‐222. The DNA mimic allows for controlled post‐functionalization with single‐stranded DNA for the attachment of protein moieties for bacterial targeting. ABSTRACT Nanosized metal–organic frameworks (MOFs) are versatile platforms used in biomedical
Anna Scheeder, Jon Ostolaza‐Paraiso, Andrew G. Baker, Juan F. Blandez, Georgina E. Lindop, Simon M. Fairclough, Ljiljana Fruk, Ioanna Mela, David Fairen‐Jimenez, Clemens F. Kaminski   +9 more
wiley   +2 more sources

ATP is dispensable for E. coli DNA replication and eukaryotic helicase activity. [PDF]

Nat Commun
Spinks RR, Lakic A, Kelso C, Jergic S, Yurieva O, Xu ZQ, O'Donnell ME, Dixon NE, van Oijen AM, Lewis JS, Spenkelink LM.   +10 more
europepmc   +1 more source

AID‐Mediated Protein Knockdown Reveals the Requirement of NANOS2 in Prenatal Gonocytes for Establishing Functional Spermatogonial Stem Cells

Development, Growth &Differentiation, Volume 68, Issue 6, August 2026.
ABSTRACT The RNA‐binding protein NANOS2 plays a crucial role in male gonocyte development and the maintenance of spermatogonial stem cells. In the absence of the Nanos2 gene (Nanos2‐KO), germ cells fail to enter G0 arrest and initiate the male differentiation program (including DNA methylation and the piRNA pathway), ultimately undergoing apoptosis ...
Yumiko Saga, Quan Wu
wiley   +1 more source

LIPT1 loss confers replication stress and PARP inhibitor sensitivity through PrimPol-mediated ssDNA gaps. [PDF]

Sci Adv
Shang Z, Chiang JC, Hsu CC, Newman C, Davis AJ, Zhang Y.   +5 more
europepmc   +1 more source