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Integrating Novel Biomarkers into Clinical Practice: A Practical Framework for Diagnosis and Management of Cardiorenal Syndrome. [PDF]

Life (Basel)
Aletras G, Bachlitzanaki M, Stratinaki M, Lamprogiannakis E, Petrakis I, Foukarakis E, Pantazis Y, Hamilos M, Stylianou K.   +8 more
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Characterisation of somatostatin sst2 receptor splice variants

Journal of Physiology-Paris, 2000
Somatostatin is a peptide with a multitude of functions in the central nervous system and the periphery. It mediates its actions by binding to high-affinity G-protein coupled receptors, genes for five of which (sst1-sst5) have recently been cloned. The somatostatin sst2 receptor exists as two splice variants, sst2(a) and sst2(b) receptors, which differ
S L, Cole, M, Schindler
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Clinical relevance of sST2 in cardiac diseases

Clinical Chemistry and Laboratory Medicine (CCLM), 2016
AbstractST2 has two main isoforms, ST2L and soluble isoform of ST2 (sST2), by alternative splicing. The interaction between interleukin (IL)-33 and the transmembrane isoform ST2L is up-regulated in response to myocardial stress and exerts cardio-protective actions in the myocardium by reducing fibrosis, hypertrophy and enhancing survival.
Domingo A. Pascual-Figal, Antonio Lax, Maria Teresa Perez-Martinez, Maria del Carmen Asensio-Lopez, Jesus Sanchez-Mas, null on behalf of GREAT Network   +5 more
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IL33 and sST2 serum level in systemic sclerosis microvascular involvement

Microvascular Research, 2022
Endothelial dysfunction and microvascular damage are hallmarks of systemic sclerosis (SSc). Objective of this study was to evaluate IL33 and ST2 serum levels in SSc patients and healthy controls (HC). Secondary aim was to evaluate the IL33 axis in the SSc microvascular manifestation.IL33 and sST2 have been assessed in 46 SSc patients and 24 HC matched ...
Pellicano C., Iannazzo F., Romaggioli L., Rosato E.   +3 more
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3-Thio-1,2,4-triazoles, novel somatostatin sst2/sst5 agonists

Bioorganic & Medicinal Chemistry Letters, 2005
Novel 3-thio-1,2,4-triazoles have been obtained via a solution-phase parallel synthesis strategy, affording potent non-peptidic human somatostatin receptor subtypes 2 and 5 agonists.
Marie-Odile, Contour-Galcéra, Alban, Sidhu, Pascale, Plas, Pierre, Roubert   +3 more
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Somatostatin receptors (sst2) regulate cGMP production in rat retina

Regulatory Peptides, 2006
The present study investigated the effect of somatostatin in the regulation of cGMP levels in rat retina and the mechanisms involved in this process. Isolated rat retinas were treated alone or in the presence of somatostatin (0.01-10 microM), BIM23014 (sst2 agonist, 0.01-10 microM), L-796,778 (sst3 agonist, 10 microM), somatostatin (0.1 microM) in ...
Niki, Mastrodimou, Foteini, Kiagiadaki, Mira, Hodjarova, Efthimia, Karagianni, Kyriaki, Thermos   +4 more
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Interleukin-33/sST2: Dynamic assessment in patients with acute coronary syndrome

Advances in Medical Sciences, 2023
Interleukin (IL)-33 and its soluble receptor ST2 (sST2) play a crucial role in the immune response. sST2 has been approved by the Food and Drug Administration as a prognostic biomarker of mortality in chronic heart failure patients, however, the role of IL-33 and sST2 in atherosclerotic cardiovascular disease remains unclear.
Anna Witkowska, Mateusz Staciwa, Iwona Duraj, Ewelina Wozniak, Marlena Broncel, Paulina Gorzelak-Pabis   +5 more
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sST2 and Galectin-3 genotyping in patients with persistent atrial fibrillation

Molecular Biology Reports, 2021
Genotyping of ST2 and galectin-3 in atrial fibrillation (AF) is not well analyzed. The aim of our study was to analyze the possible relationship between levels of sST2 and galectin-3 and three polymorphisms in patients with AF. We included 125 patients with persistent AF undergoing electric cardioversion.
Ruth Saez-Maleta, Ana Merino-Merino, Simon Gundin-Menendez, Ricardo Salgado-Aranda, Daniel AlKassam-Martinez, Virginia Pascual-Tejerina, Javier Martin-Gonzalez, Javier Garcia-Fernandez, Jose-Angel Perez-Rivera   +8 more
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Dosage du récepteur soluble sST2 : perspectives

Revue Francophone des Laboratoires, 2017
Resume L’insuffisance cardiaque (IC) est un probleme majeur pour nos societes contemporaines tant en termes de prevalence, de mortalite et de cout. Les peptides natriuretiques sont des biomarqueurs reconnus pour l’aide au diagnostic d’IC mais aussi pour la stratification du risque des patients.
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Role of Sst2 in Modulating G Protein-Coupled Receptor Signaling

Biochemical and Biophysical Research Communications, 1996
Sst2 formally acts as an inhibitor of G protein-coupled receptor signaling in yeast perhaps stabilizing a G protein/unactivated receptor complex. desTrp1,Ala3 alpha-factor (dTA-alpha f), normally a competitive antagonist, activated responses in an sst2 strain.
A, Shah, L, Marsh
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