Results 61 to 70 of about 5,477 (176)
The Effects of Replacing Sst2 with the Heterologous RGS4 on Polarization and Mating in Yeast [PDF]
Biophysical Journal, 2010 RGS proteins stimulate the deactivation of heterotrimeric G-proteins. The yeast RGS protein Sst2 is regulated at both the transcriptional and posttranscriptional levels. We replaced the SST2 gene with the distantly related human RGS4 gene, which consists of the catalytic domain and an N-terminal membrane attachment peptide, and replaced the native ...
Tanaka, Hiromasa, Yi, Tau-Mu
openaire +2 more sources
Biomarkers to predict outcomes in diabetic foot ulcers
VIEW, EarlyView.Studies attempting to predict the healing outcome of diabetic foot ulcers (DFUs) have investigated various biological materials and recovered molecules that may aid in discriminating wounds that will heal and those that will not heal. This graphical abstract captures the commonly studied classes of biomarkers in the context of DFUs.
Julie Okiro +6 more
wiley +1 more source
Levels of circulating sST2 in patients with hypertension and atrial fibrillation
Medicine Today and Tomorrow, 2022 The article presents the results of studying the variability of the level of soluble growth stimulating factor expressed by gene 2 (sST2) in plasma in patients with hypertension depending on various clinical characteristics. An open observational one-point randomized comparative study included 118 patients with stage II hypertension.
V.P. Ivanov, M.M. Zakrevska
openaire +1 more source
Scientific ReportsSoluble ST2 (sST2) is released in response to vascular congestion, inflammation, and pro-fibrotic stimuli. In heart failure (HF), elevated levels of sST2 are associated with a higher risk of adverse clinical outcomes.
Elena Revuelta-López +7 more
doaj +1 more source
Antibody–Drug Conjugates and Peptide–Drug Conjugates: Current Understandings and Future Perspectives
MedComm, Volume 7, Issue 8, August 2026.The graphic summarizes the design principles, intracellular trafficking, clinical progress, challenges, and future directions of antibody–drug conjugates (ADCs) and peptide–drug conjugates (PDCs). ADCs consist of a tumor‐targeting antibody, a chemical linker, and a potent payload, whereas PDCs use peptide ligands to deliver cytotoxic, radionuclide, or ...
Ruxi Zheng +9 more
wiley +1 more source
Acute Myocarditis: From Pathophysiology to Risk‐Stratified Management—A Clinical Review
European Journal of Clinical Investigation, Volume 56, Issue 8, August 2026.Stepwise approach to patients with suspected acute myocarditis, integrating the 2024 American College of Cardiology (ACC) four‐stage classification (Stages A–D) and the 2025 European Society of Cardiology (ESC) inflammatory myopericardial syndrome (IMPS) framework. Step 1 (Initial Assessment): clinical presentation, first‐line investigations (ECG, high‐
Michele Golino +9 more
wiley +1 more source
BMC Cardiovascular DisordersAim The objective of this study was to investigate the level of soluble suppression of tumorigenicity-2 (sST2) in patients with acute ST-segment elevation myocardial infarction (STEMI) following primary percutaneous coronary intervention (PCI), and to ...
Shan Huang +3 more
doaj +1 more source
Clinical Pharmacology in Drug Development, Volume 15, Issue 7, July 2026.Abstract Paltusotine is a novel, nonpeptide, once‐daily oral, selective somatostatin 2 receptor (SST2) agonist. We evaluated the pharmacokinetics, pharmacodynamics, and safety of oral paltusotine in healthy Japanese adults in single‑dose (20, 40, 60, 80 mg) and repeated‑dose (40 mg once daily for 7 days in a two‐sequence, two‑period crossover design ...
Fumio Otsuka +7 more
wiley +1 more source
Addressing the World War 2 Warm Anomaly in HadSST.4.2.0.0
International Journal of Climatology, Volume 46, Issue 8, 30 June 2026.We present an update to the Hadley Centre Sea‐Surface Temperature dataset (HadSST.4.2.0.0) that addresses residual warm bias during the Second World War (WW2). Using a quantitative definition of the WW2 warm anomaly we identify Engine Room Intake (ERI) bias corrections as the dominant factor in HadSST4, and use this to propose new constraints on ERI ...
Caroline Sandford, Nick Rayner
wiley +1 more source
The FASEB Journal, Volume 40, Issue 12, 30 June 2026.Analyses of cytochrome P450 1a (CYP1A)‐knockout (KO) Javanese medaka (Oryzias javanicus) revealed that CYP1A is involved in glucose regulation and reproduction. In the KO fish, significant increases in hepatic transcripts of insulin, glucagon, and somatostatin genes, as well as elevated blood glucose, liver mass, and liver triglyceride levels ...
Suhaila Rusni +10 more
wiley +1 more source