Results 81 to 90 of about 8,618 (210)

Mitochondrial Transplantation as a New Therapeutic Approach Against Cardiac and Renal Consequences in Male Rats With Myocardial Infarction

Acta Physiologica, Volume 242, Issue 6, June 2026.
ABSTRACT Aim Myocardial infarction (MI) is one of the leading causes of death worldwide. MI is associated with cardiac structural and functional alterations. Among these, cardiac fibrosis may be significantly influenced by mitochondrial dysfunction. We sought to evaluate whether the injection of functional mitochondria from healthy muscle could improve
María Cuesta‐Corral, Alejandro Montoro‐Garrido, Ana Romero‐Miranda, Fabián Islas, Bunty Ramchandani, Ricardo Gredilla, Joaquín Fernández‐Irigoyen, Enrique Santamaría, Beatriz Delgado‐Valero, Sara Jiménez‐González, Raquel Rodrigues Díez, María Luisa Nieto, Victoria Cachofeiro, Ernesto Martínez‐Martínez   +13 more
wiley   +1 more source

sST2: a new kid on the block for patients with ACHD [PDF]

Heart, 2019
Adults with congenital heart disease (ACHD) are an increasing and ageing population.1 Despite all advances in medical and surgical treatment, patients with ACHD are still afflicted by significant morbidity and mortality.2 Timely identification of those patients that are at risk can be difficult.
openaire   +2 more sources

Elevated Sera sST2 Is Associated With Heart Failure in Men ≤50 Years Old With Myocarditis

Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease, 2019
Background Myocarditis is an important cause of acute and chronic heart failure. Men with myocarditis have worse recovery and an increased need for transplantation compared with women, but the reason for the sex difference remains unclear.
Michael Coronado, K. A. Bruno, L. Blauwet, C. Tschöpe, M. Cunningham, S. Pankuweit, S. Van Linthout, E. Jeon, D. McNamara, J. Krejci, J. Bienertová-Vašků, E. J. Douglass, E. Abston, Adriana Bucek, J. Frisancho, Merci S. Greenaway, Anneliese R. Hill, H. Schultheiss, L. Cooper, D. Fairweather   +19 more
semanticscholar   +1 more source

Expression of the Novel Cardiac Biomarkers sST2, GDF-15, suPAR, and H-FABP in HFpEF Patients Compared to ICM, DCM, and Controls

Journal of Clinical Medicine, 2020
Background: Heart failure with preserved ejection fraction (HFpEF) remains an ongoing therapeutic and diagnostic challenge to date. In this study we aimed for an analysis of the diagnostic potential of four novel cardiovascular biomarkers, GDF-15, H-FABP,
P. Jirak, R. Pistulli, M. Lichtenauer, B. Wernly, V. Paar, L. Motloch, R. Rezar, C. Jung, U. Hoppe, P. C. Schulze, D. Kretzschmar, Rüdiger C. Braun-Dullaeus, T. Bekfani   +12 more
semanticscholar   +1 more source

Circulating Level of Growth‐Differentiation Factor 15 and Mortality of Patients With Acute Heart Failure: A Meta‐Analysis

Clinical Cardiology, Volume 49, Issue 5, May 2026.
Elevated admission GDF‐15 levels are associated with increased mortality in acute heart failure. This meta‐analysis of 10 studies (N = 3724) found a pooled RR of 2.82 (95% CI: 2.39–3.32; p < 0.001; I² = 0%), supporting GDF‐15 as a promising biomarker for early risk stratification in AHF patients.
Pingkui Jin, Yanjie Geng, Erwei Huo, Yanhong Xue, Daofeng You, Qinghou Zheng   +5 more
wiley   +1 more source

Short-term predictive value of sST2 in patients with STEMI following primary PCI: a prospective observational study

BMC Cardiovascular Disorders
Aim The objective of this study was to investigate the level of soluble suppression of tumorigenicity-2 (sST2) in patients with acute ST-segment elevation myocardial infarction (STEMI) following primary percutaneous coronary intervention (PCI), and to ...
Shan Huang, Lu-Jiao Yu, Guang-Feng Sun, Zi-Xin Zhang   +3 more
doaj   +1 more source

IL-33 (Interleukin 33)/sST2 Axis in Hypertension and Heart Failure [PDF]

Hypertension, 2018
IL-33 (interleukin 33) is type of cytokine designated an alarmin, which is released under stress conditions or by cell death to induce protective measures in neighboring cells.1 It signals via the ST2 (suppression of tumorigenicity 2) receptor, which is also expressed as a truncated and soluble form that acts as a decoy receptor soluble ST2 (sST2).2 ...
Ghali, Rana, Altara, Raffaele, Louch, William E, Cataliotti, Alessandro, Mallat, Ziad, Kaplan, Abdullah, Zouein, Fouad A, Booz, George W   +7 more
openaire   +2 more sources

Circulating sST2 and catestatin levels in patients with acute worsening of heart failure: a report from the CATSTAT‐HF study

ESC Heart Failure, 2020
Soluble suppression of tumourigenicity 2 (sST2) and catestatin (CST) reflect myocardial fibrosis and sympathetic overactivity during the acute worsening of heart failure (AWHF).
J. Borovac, D. Glavaš, Zora Sušilović Grabovac, D. Šupe Domić, Lada Stanišić, D. D’Amario, C. Kwok, J. Božić   +7 more
semanticscholar   +1 more source

Novel drugs approved by the EMA, the FDA and the MHRA in 2025: A year in review

British Journal of Pharmacology, Volume 183, Issue 9, Page 1779-1813, May 2026.
Abstract In the 2025 novel drug mini‐review, one can take a full measure of the ingenuity that underlies current drug design and development, despite the year's smaller harvest (46 novel drugs) compared to 2024 (53) and 2023 (70). 54% of the novel drugs are first‐in‐class (FIC).
Andreas Papapetropoulos, Stavros Topouzis, Steve P. H. Alexander, Miriam M. Cortese‐Krott, Zsuzsanna Helyes, Kirill Martemyanov, Claudio Mauro, Nithyanandan Nagercoil, Reynold A. Panettieri Jr, Hemal H. Patel, Rainer Schulz, Barbara Stefanska, Gary J. Stephens, Nathalie Vergnolle, Xin Wang, Stephen Ward, Péter Ferdinandy   +16 more
wiley   +1 more source

Cellular Noise Suppression by the Regulator of G Protein Signaling Sst2 [PDF]

Molecular Cell, 2014
G proteins and their associated receptors process information from a variety of environmental stimuli to induce appropriate cellular responses. Generally speaking, each cell in a population responds within defined limits despite large variation in the expression of protein signaling components.
Dixit, Gauri, Kelley, Joshua B., Houser, John R., Elston, Timothy C., Dohlman, Henrik G.   +4 more
openaire   +2 more sources