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The role of ST2 and ST2 genetic variants in schistosomiasis [PDF]

open access: yesJournal of Allergy and Clinical Immunology, 2017
Chronic schistosomiasis and its severe complication, periportal fibrosis, are characterized by a predominant Th2 response. To date, specific single nucleotide polymorphisms in ST2 have been some of the most consistently associated genetic variants for asthma.We investigated the role of ST2 (a receptor for the Th2 cytokine IL-33) in chronic and late ...
Li Gao, Huifang Liang, Xiaoping Chen
exaly   +3 more sources
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The Biology of ST2: The International ST2 Consensus Panel

The American Journal of Cardiology, 2015
ST2 is a member of the interleukin 1 receptor family with 2 main isoforms: transmembrane or cellular (ST2L) and soluble or circulating (sST2) forms. ST2 is the receptor of the IL-33, which is an IL-1-like cytokine that can be secreted by living cells in response to cell damage.
Domingo A, Pascual-Figal   +1 more
  +7 more sources

Soluble ST2 in Heart Failure

Heart Failure Clinics, 2018
Suppression of tumorigenicity 2 (ST2) is a member of the interleukin (IL)-1 receptor family, whose role was originally established in the context of inflammatory and autoimmune diseases. More recently, testing for ST2 has been used in the setting of cardiovascular disease.
Cian P McCarthy, James Januzzi
exaly   +3 more sources

ST2 in Pulmonary Disease

The American Journal of Cardiology, 2015
In recent years, numerous studies have focused on the use of soluble ST2 (sST2) as a clinical biomarker for cardiovascular disease. However, much preclinical data points to involvement of the ST2 pathway in inflammation, and specifically in pulmonary inflammation. This report summarizes the current body of clinical data suggesting the potential role of
Ednan K, Bajwa   +2 more
openaire   +2 more sources

ST2 and Prognosis in Acutely Decompensated Heart Failure: The International ST2 Consensus Panel

The American Journal of Cardiology, 2015
ST2 is a member of the interleukin (IL) 1 receptor family that exists in 2 forms, a transmembrane receptor (ST2L) and a soluble receptor (sST2). The ligand of ST2 is IL-33, known to be involved in reducing tissue fibrosis and myocyte hypertrophy in mechanically strained hearts.
Januzzi, James L.   +2 more
openaire   +2 more sources

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