Results 41 to 50 of about 4,650,966 (303)

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Prediction of stability constants of Cu2+ complexes with organic fluorescent ligands using thermodynamic cycle in combination with DFT theory and SMD solvent model

open access: yesTạp chí Khoa học Đại học Huế: Khoa học Tự nhiên, 2020
Accurately predicting the stability constant ( ) of the Cu2+ complex with organic fluorescent ligands provides an important basis to design molecular fluorescent sensors for selective detection of Cu2+.
Mai Van Bay   +4 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Conductometric, Spectrophotometric and Computational Investigation of Binary and Ternary Complexes of Co(II) and Cu(II) Bivalent Metal Ions with L-Valine Amino Acid and Paracetamol Drug

open access: yesJournal of the Turkish Chemical Society, Section A: Chemistry, 2023
65 Türkçe Barbaros AKKURT Journal of the Turkish Chemical Society Section A: Chemistry Araştırma Makalesi EN Conductometric, Spectrophotometric and Computational Investigation of Binary and Ternary Complexes of Co(II) and ...
Aisha ALABBASİ   +3 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Studies on Nickel(II)-Pyridoxamine-Imidazole Containing Mixed Ligand Complex Systems [PDF]

open access: yesIranian Journal of Chemistry & Chemical Engineering, 2004
The stability constants of species present in the systems Ni(II)-pyridoxamine(pym)(A) and Ni(II)-pyridoxamine(pym)(A)-imidazole containing ligands(B) [B = imidazole(him),  benzimidazole(bim), histamine(hist) and L-histidine(his)] have been determined pH ...
M.A Neelakantan, M . Sivasankaran Nair
doaj  

РАСЧЕТ ТЕРМОДИНАМИЧЕСКИХ ПАРАМЕТРОВ ПРОЦЕССОВ НА ПРИМЕРЕ РЕАКЦИЙ КОМПЛЕКСООБРАЗОВАНИЯ

open access: yesJournal of Bioinformatics and Genomics, 2023
В статье описан процесс расчета основных термодинамических показателей комплексообразования химических соединений, отличающихся особым типом взаимодействия – донорно-акцепторным взаимодействием.
Шачнева Е.Ю.
doaj   +1 more source

The Cosmological Constant and Stability of the Higgs Vacuum [PDF]

open access: yesActa Physica Polonica B, 2016
6 pages, invited talk at the Jagiellonian Symposium on Fundamental and Applied Subatomic Physics, Cracow, Poland, June 7-12 ...
openaire   +2 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

RIGIDITY AND SHARP STABILITY ESTIMATES FOR HYPERSURFACES WITH CONSTANT AND ALMOST-CONSTANT NONLOCAL MEAN CURVATURE [PDF]

open access: yes, 2016
. We prove that the boundary of a (not necessarily connected) bounded smooth set with constant nonlocal mean curvature is a sphere. More generally, and in contrast with what happens in the classical case, we show that the Lipschitz constant of the ...
M. Novaga   +3 more
core   +3 more sources

Home - About - Disclaimer - Privacy