Results 111 to 120 of about 149,041 (310)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Stability Constants of Some Bivalent Metal Chelates of O-Thymol Aldoxime [PDF]

, 1972
Chemical Laboratories, Government Science College, Gwalior (M.P.) Received 5 January 1972 Stability constants of complexes of some bivalent metals viz., UO2+2 , Cu+2, Ni+2 and Co+2 with O-Thymol aldoxime have been determined potentiometrically in 75 ...
S. L. GARG, K . K. PANDAY
core   +1 more source

[15]aneN4S: Synthesis, Thermodynamic Studies and Potential Applications in Chelation Therapy

Molecules, 2014
The purpose of this work was to synthesize and characterize the thiatetraaza macrocycle 1-thia-4,7,10,13-tetraazacyclopentadecane ([15]aneN4S). Its acid-base behaviour was studied by potentiometry at 25 °C and ionic strength 0.10 M in KNO3.
Nuno Torres, Sandrina Gonçalves, Ana S. Fernandes, J. Franco Machado, Maria J. Villa de Brito, Nuno G. Oliveira, Matilde Castro, Judite Costa, Maria F. Cabral   +8 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Determination of quercetin in pharmaceutical formations via its reaction with potassium titanyloxalate. Determination of the stability constants of the quercetin titanyloxalato complex [PDF]

Journal of the Serbian Chemical Society, 2005
Asimple, rapid and accurate procedure for the quantitative determination of quercetin in its pure form and in formulations has been developed. The method is based on the spectrophotometric determination of a complex formed between quercetin and potassium
DUSAN MALESEV, VLADANA VUKOJEVIC, ZORICA VUJIC, SVETLANA MISIC, NATASA PEJIC, VESNA KUNTIC   +5 more
doaj  

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Stability Constants of Rhodizonic Acid Complexes in Solution [PDF]

, 1979
Chemical Laboratories, Indian School of Mines, Dhanbad-826004 Manuscript received 26 November 1976, revised 21 November 1978, accepted 22 December 1978 Stability Constants of Rhodizonic Acid Complexes in ...
NARENDRA S. RAWAT, SRIKUMAR MUKHERJEE
core   +1 more source

18-Crown-6 and Dibenzo-18-crown-6 Assisted Extraction of Cesium from Water into Room Temperature Ionic Liquids and Its Correlation with Stability Constants for Cesium Complexes

Molecules, 2009
The pH-profiles of the extraction of Cs+ into four conventional (1-butyl-3-methylimidazolium hexafluorophosphate and bis[trifluoromethyl)sulphonyl]imides of 1-butyl-3-methylimidazolium, 1-hexyl-3-methylimidazolium, and 1-(2-ethylhexyl)-3 ...
Igor Vladimirovich Pletnev, Vladimir Georgyevich Krasovsky, Konstantin Ivanovich Popov, Irina Ivanovna Torocheshnikova, Svetlana Valeryevna Smirnova, Andrey Grigoryevich Vendilo, Dmitry Ivanovich Djigailo   +6 more
doaj   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Mössbauer Spectroscopic Determination of Stability Constants of Fluorostannate (II) Complexes [PDF]

, 2013
Stability constants of fluorostannate(II) complexes were determined Mossbauer spectroscopically by rapid freezing technique. The observed isomer shift values suggested that these complexes were hydrogen bonded in perchloric acid solutions ...
鄭華生; Cheng, H. S.; 徐健生; Hsu, C. M.; 魏和祥; Wei, Ho-hsiang
core   +1 more source