Results 91 to 100 of about 2,700,096 (301)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Low subsonic dynamic-stability investigation of several planetary-entry configurations in a vertical wind tunnel, part i [PDF]
Low subsonic dynamic stability data for evaluation of ballistic deceleration vehicle entering Mars ...
Marte, J. E., Weaver, R. W.
core +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Investigating Differences in Bicarbonate Levels: Exploring Discrepancies between Venous and Arterial Measurements and Evaluating Stability through Time-point Assessments [PDF]
Indian Journal of Medical BiochemistryIntroduction: Evaluation of acid-base status is crucial in critical care settings, with bicarbonate serving as a key indicator of electrolyte distribution and anion deficit.
Shobha C Ramachandra +3 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Evaluation of Indomethacin Stability
East Asian Journal of Multidisciplinary ResearchIndomethacin is a non-steroidal anti-inflammatory drug (NSAID) that is most often used to treat inflammation and pain due to rheumatic diseases. Forced degradation is carried out to save time in carrying out contamination analysis on pharmaceutical preparations. Forced degradation is carried out by providing extreme exposure conditions. The aim of this
Anita Ratna Dilla, Supriyadi Karneli
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In vitro stability evaluation of coated lipase
Asian-Australasian Journal of Animal Sciences, 2016 The study was conducted to evaluate the stability of commercial coated lipase (CT-LIP) in vitro.The capsules were tested under different conditions with a range of temperature, pH, dry heat treatment and steaming treatment, simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) in this work, respectively.
Liu, Lu Jie +5 more
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FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
A Methodology for Afterburner Evaluation [PDF]
, 1996 A preliminary investigation of the performance of an afterburner module proposed by the Gas Turbine Research Establishment, Bangalore for the Kaveri engine has been carried out.
Haran, AP +6 more
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