Results 111 to 120 of about 2,700,096 (301)

Influence of variability in starting materials quality on stability of finished drug products: a quality-by-design factor and response [PDF]

, 2012
The use of ill selected excipients in drug formulations can have a significant influence on the overall stability. Therefore, evaluation of chemical and physical excipient compatibility with the API has become a major part in the development of new drug ...
Bauters, Tieneke, D'Hondt, Matthias, De Spiegeleer, Bart, Robays, Hugo, Vandenbroucke, Johan, Wynendaele, Evelien   +5 more
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Stability of dangerous rockmasses and prediction of rockfall trajectory: A case study at Wansui Mountain in Ganzi County of Sichuan Province

Zhongguo dizhi zaihai yu fangzhi xuebao
The hazardous rock zone on the Wansui Mountain slope in Ganzi Town, Ganzi County, has experienced frequent rockfalls over the years, posing a serious threat to the lives and property of residents below.
Yuyuan WANG, Youyi ZHANG, Yunjun WANG
doaj   +1 more source

COMPARISON OF TWO CHICKEN GENOTYPES ORGANICALLY REARED: OXIDATIVE STABILITY AND OTHER QUALITATIVE TRAITS [PDF]

, 2006
The effect of genotype on the oxidative stability and other qualitative traits of chicken meat was studied. Two groups of 200 chicks (Ross 205 and Kabir) were reared according to the organic farming system.
CASTELLINI, prof C, DAL BOSCO, dr A, MUGNAI, dr C, PEDRAZZOLI, dr M   +3 more
core  

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

CO2 storage potential of coal seam in Sanhejian closed coal mine

Meitan kexue jishu
Geological sequestration of CO2 in closed coal mines' coal seams is a significant method for CO2 sequestration and an effective strategy to achieve short-term carbon emission reduction goals.
Jing QIAN, Gaofeng YI, Qizhong ZHOU, Zhigang TANG, Yixuan PENG, Yang WANG, Shangbin CHEN   +6 more
doaj   +1 more source

An Exploratory Study of Suboxone (Buprenorphine/ Naloxone) Film Splitting: Cutting Methods, Content Uniformity, and Stability [PDF]

, 2019
Suboxone films are U.S. Food and Drug Administration approved to treat opioid dependence. While the package insert states that films should not be cut, physicians often prescribe film fractions for treatment and tapering. There is no data to support this
Conn, Kelly, Corigliano, Anthony, DeAngelis, Michael J., Ferrara, Alexander S., Phillips, Elizabeth, Reindel, Kristin L., Zhao, Fang   +6 more
core   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Stability evaluation and mitigation strategies of unstable rock masses using 3D oblique photogrammetry and RocFall: A case study of Shanyi village, Xishan of Kunming

Zhongguo dizhi zaihai yu fangzhi xuebao
High-position unstable rock masses above Shanyi village in the Xishan of Kunming pose a serious threat to the safety of residents and critical transportation infrastructure below.
Bo YAO, Shengdong HUANG, Chaoyang WANG, Zhaomin ZHANG, Jipu CHEN   +4 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source