Results 121 to 130 of about 2,700,096 (301)

Generative model and application framework for stability evaluation of salt cavern hydrogen storage facilities

Yantu gongcheng xuebao
Amid the accelerating transformation of the global energy structure, hydrogen energy, with its characteristics of abundant resources and zero carbon emissions, has emerged as a crucial part of China's energy development strategy.
LEI Huayang 1, 2, ZHANG Xinyu 1, XU Yinggang 1
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Stability Evaluation of Vegetation-Covered Highway Slopes Employing Integrated CR-InSAR and Finite Element Simulation

Remote Sensing
Highway slopes susceptible to landslides are typically reinforced by vegetation cover and the application of concrete frame beams, but vegetation cover may degrade the accuracy of InSAR deformation monitoring.
Wei Peng, Jiachen Zhou, Junhui Zhang, Jun Zhu, Xuemin Xing, Shiping Zhang   +5 more
doaj   +1 more source

LOX/Hydrocarbon Combustion Instability Investigation [PDF]

The LOX/Hydrocarbon Combustion Instability Investigation Program was structured to determine if the use of light hydrocarbon combustion fuels with liquid oxygen (LOX) produces combustion performance and stability behavior similar to the LOX/hydrogen ...
Claflin, S. E., Dodson, H. C., Jensen, R. J.   +2 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Stability Evaluation Method for Rock Slope-Anchorage Systems Based on Genetic Algorithms and Discrete Element Analysis

Applied Sciences
With the increasing scale of infrastructure projects in sectors such as hydraulics and transportation, coupled with the widespread adoption of anchorage support technologies, numerous rock slope anchorage systems have been established.
Peng Xia, Bowen Zeng, Yiheng Pan
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Evaluation of impact of surface dynamic subsidence on construction of pumped storage hydropower plants in abandoned open-pit mines

Meitan kexue jishu
Surface dynamic subsidence is one of the key scientific issues that need to be solved urgently when constructing pumped storage hydropower plant in abandoned mines.
Yang LI, Xinghai LEI, Nan WANG, Yuqi REN, Xiangyang JIN, Ke WANG, Kuichao JIANG, Peng GE, Xue XIA, Tiezheng LI, Xiaoming SHI, Yuliang WANG   +11 more
doaj   +1 more source