Results 101 to 110 of about 116,780,660 (304)

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Robust Stability of Iterative Learning Control Schemes

, 2008
A notion of robust stability is developed for iterative learning control in the context of disturbance attenuation. The size of the unmodelled dynamics is captured via a gap distance, which in turn is related to the standard H2 gap metric, and the ...
French, Mark
core  

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

LMIs - a Fundamental Tool in Analysis and Controller Design for Discrete Linear Repetitive Processes [PDF]

, 2002
Discrete linear repetitive processes are a distinct class of 2D linear systems with applications in areas ranging from long-wall coal cutting through to iterative learning control schemes.
Owens, D H, D. H. Owens, Rogers, E, J. Lam, S. Xu, Lam, J, Owens, DH, K. Galkowski, Eric Rogers, Galkowski, K, Senior Member, Xu, S   +11 more
core   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Robust exponential point stabilization control of the high-speed underactuated unmanned marine vehicle with model asymmetry

International Journal of Advanced Robotic Systems, 2019
Point stabilization control of a class of asymmetric underactuated high-speed unmanned marine vehicle is discussed, and a robust exponential stabilization control algorithm is proposed based on homogeneous theory, average system theory, and nonlinear ...
Zaopeng Dong, Yabin Wang, Lifei Song, Mao Zheng, Shixin Chu, Yunsheng Mao   +5 more
doaj   +1 more source

KYP lemma based stability and control law design for differential linear repetitive processes with applications

, 2013
Repetitive processes are a class of two-dimensional systems that have physical applications, including the design of iterative learning control laws where experimental validation results have been reported.
Galkowski, Krzysztof, Paszke, Wojciech, Rogers, Eric   +2 more
core   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Strong practical stability and stabilization of discrete linear repetitive processes

, 2009
This paper considers two-dimensional (2D) discrete linear systems recursive over the upper right quadrant described by well known state-space models. Included are discrete linear repetitive processes that evolve over subset of this quadrant.
Dabkowski, P, Kummert, A, Galkowski, K, Rogers, Eric   +3 more
core   +1 more source