Results 31 to 40 of about 13,204,286 (295)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Lyapunov theory demonstrating a fundamental limit on the speed of systems consolidation

Physical Review Research
This article is part of the Physical Review Research collection titled Physics of Neuroscience. The nervous system reorganizes memories from an early site to a late site, a commonly observed feature of learning and memory systems known as systems ...
Alireza Alemi, Emre R. F. Aksay, Mark S. Goldman   +2 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

The impact of cognitive schema on learning transfer ability and stability of classical Chinese poetry.

PLoS ONE
Classical Chinese poetry is a condensed vessel of Chinese culture, bearing the core ethos of history, philosophy, and ethics. The symbolic imagery system in poetry facilitates the construction of cognitive schemata, thereby advancing transfer learning ...
Dawei Liu, Ping He, Huifen Yan
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

R-L-Based Distributed Sliding Mode Control for Isomorphic Complex Network

Tsinghua Science and Technology
In this paper, we discuss the distributed optimal Sliding Mode Control (SMC) issue for the isomorphic complex network in view of learning theory. Firstly, a dynamic distributed SMC strategy is introduced innovatively by virtue of Reinforcement Learning ...
Guangchen Zhang, Zheng Zhou, Yuanqing Xia, Shuping He   +3 more
doaj   +1 more source

Discovery of 2D Materials using Transformer Network‐Based Generative Design

Advanced Intelligent Systems, 2023
Two‐dimensional (2D) materials offer great potential in various fields like superconductivity, quantum systems, and topological materials. However, designing them systematically remains challenging due to the limited pool of fewer than 100 experimentally
Rongzhi Dong, Yuqi Song, Edirisuriya M. D. Siriwardane, Jianjun Hu   +3 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

A 2D system approach to the design of a robust modified repetitive-control system with a dynamic output-feedback controller

International Journal of Applied Mathematics and Computer Science, 2014
This paper is concerned with the problem of designing a robust modified repetitive-control system with a dynamic output feedback controller for a class of strictly proper plants.
Zhou Lan, She Jinhua, Zhou Shaowu
doaj   +1 more source

C-GAIL: Stabilizing Generative Adversarial Imitation Learning with Control Theory

Advances in Neural Information Processing Systems 37
Generative Adversarial Imitation Learning (GAIL) trains a generative policy to mimic a demonstrator. It uses on-policy Reinforcement Learning (RL) to optimize a reward signal derived from a GAN-like discriminator. A major drawback of GAIL is its training instability - it inherits the complex training dynamics of GANs, and the distribution shift ...
Tianjiao Luo, Tim Pearce, Huayu Chen, Jianfei Chen 0001, Jun Zhu 0001   +4 more
openaire   +3 more sources