Results 41 to 50 of about 953,953 (275)
Discovery of 2D Materials using Transformer Network‐Based Generative Design
Advanced Intelligent Systems, 2023 Two‐dimensional (2D) materials offer great potential in various fields like superconductivity, quantum systems, and topological materials. However, designing them systematically remains challenging due to the limited pool of fewer than 100 experimentally
Rongzhi Dong +3 more
doaj +1 more source
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
International Journal of Applied Mathematics and Computer Science, 2014 This paper is concerned with the problem of designing a robust modified repetitive-control system with a dynamic output feedback controller for a class of strictly proper plants.
Zhou Lan, She Jinhua, Zhou Shaowu
doaj +1 more source
Realizable Learning is All You Need [PDF]
TheoretiCSThe equivalence of realizable and agnostic learnability is a fundamental phenomenon in learning theory. With variants ranging from classical settings like PAC learning and regression to recent trends such as adversarially robust learning, it's surprising
Max Hopkins +3 more
doaj +1 more source
Remote Monitoring in Myasthenia Gravis: Exploring Symptom Variability
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Myasthenia gravis (MG) is a rare, autoimmune disorder characterized by fluctuating muscle weakness and potential life‐threatening crises. While continuous specialized care is essential, access barriers often delay timely interventions. To address this, we developed MyaLink, a telemedical platform for MG patients.
Maike Stein +13 more
wiley +1 more source
A reinforcement learning theory for homeostatic regulation [PDF]
, 2011 Reinforcement learning models address animal’s behavioral adaptation to its changing “external” environment, and are based on the assumption that Pavlovian, habitual and goal-directed responses seek to maximize reward acquisition.
Gutkin, B. S., Keramati, M.
core
From synaptic interactions to collective dynamics in random neuronal networks models: critical role of eigenvectors and transient behavior [PDF]
, 2018 The study of neuronal interactions is currently at the center of several neuroscience big collaborative projects (including the Human Connectome, the Blue Brain, the Brainome, etc.) which attempt to obtain a detailed map of the entire brain matrix. Under
Chialvo, Dante R. +4 more
core +2 more sources
Complexity, 2022 This paper proposes an adaptive formation tracking control algorithm optimized by Q-learning scheme for multiple mobile robots. In order to handle the model uncertainties and external disturbances, a desired linear extended state observer is designed to ...
Chen Zhang +4 more
doaj +1 more source
Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina +11 more
wiley +1 more source