Results 51 to 60 of about 83,069 (252)

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source

Learning Transformed Dynamics for Efficient Control Purposes

Mathematics
Learning linear and nonlinear dynamical systems from available data is a timely topic in scientific machine learning. Learning must be performed while enforcing the numerical stability of the learned model, the existing knowledge within an informed or ...
Chady Ghnatios, Joel Mouterde, Jerome Tomezyk, Joaquim Da Silva, Francisco Chinesta   +4 more
doaj   +1 more source

Learning a DFT-based sequence with reinforcement learning: a NAO implementation

Paladyn, 2012
The implementation of sequence learning in robotic platforms offers several challenges. Deciding when to stop one action and continue to the next requires a balance between stability of sensory information and, of course, the knowledge about what action ...
Durán Boris, Lee Gauss, Lowe Robert
doaj   +1 more source

A Two‐Stage Questionnaire and Actigraphy Screening for iRBD in a Multicenter Retrospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Isolated rapid‐eye‐movement sleep behavior disorder is a prodromal marker of synucleinopathies. However, most cases remain undiagnosed due to the insufficient predictive value of questionnaires and limited access to confirmatory video‐polysomnography. We assessed a two‐stage screening strategy combining a brief questionnaire on rapid‐
Caleb A. Massimi, Giorgio Ricciardiello Mejia, Andre Metzger, Kang Hyun Ryu, Salonee Marwaha, Eva Grzegorczyk, Li Zhou, Eliana Jacobs, Boris Gilyadov, Claudia Kunney, Liqhwa Ncube, Ankit Parekh, Emmanuel Mignot, Fanny M. Elahi, Joseph Winer, Kathleen Poston, Andreas Brink‐Kjaer, Emmanuel H. During   +17 more
wiley   +1 more source

Cognitive and Neuroimaging Divergence Between Juvenile and Adult FUS Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive motor neuron degeneration. Fused in sarcoma (FUS)‐associated juvenile ALS (jALS) represents a distinct and aggressive subgroup with rapid deterioration and poor prognosis.
Alexandra V. Jürs, Marcel Naumann, Annaliis Lehto, Hanna Schön, Jens Kurth, Johannes Prudlo, Andreas Hermann, Elisabeth Kasper   +7 more
wiley   +1 more source

Fine-Tuning Quadcopter Control Parameters via Deep Actor-Critic Learning Framework: An Exploration of Nonlinear Stability Analysis and Intelligent Gain Tuning

IEEE Access
Quadcopters have underactuated, nonlinear, and coupled dynamics, making their control a challenging endeavor. However, PID controllers have exhibited remarkable performance for such systems in a variety of circumstances, including obstacle avoidance ...
Hassan Moin, Umer Hameed Shah, Muhammad Jawad Khan, Hasan Sajid   +3 more
doaj   +1 more source

Exploration and Exploitation of New Knowledge Emergence to Improve the Collective Intelligent Decision-Making Level of Web-of-Cells With Cyber-Physical-Social Systems Based on Complex Network Modeling

IEEE Access, 2018
Through exploration and exploitation of new knowledge emergence, the collective intelligent decision-making (CID) level of Web-of-Cells (WoC) proposed by ELECTRA will be dramatically improved.
Lefeng Cheng, Tao Yu
doaj   +1 more source

A 57‐Year‐Old Male With Behavioral Variant Frontotemporal Dementia and MATR3 and NOS3 Mutations

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT This report presents a case of behavioral variant frontotemporal dementia caused by mutations in the MATR3 and NOS3 genes, aiming to analyze its clinical manifestations and genetic characteristics. For a case presenting with personality changes and gait abnormalities as the initial symptoms, this study conducted a comprehensive analysis of its
Feifei Lin, Saie Huang
wiley   +1 more source

SMC-Based, Stability-Guided Deep Reinforcement Learning for Control of Uncertain Nonlinear Dynamic Systems

IEEE Access
This paper presents a novel control framework that integrates the stability insights of traditional control with reinforcement learning (RL) to tackle uncertain nonlinear dynamic systems.
Mahya Ramezani, M. Amin Alandihallaj, Andreas M. Hein, Holger Voos   +3 more
doaj   +1 more source

Quantitative MRI Uncovers Subtle Cortical Damage in Myelin Oligodendrocyte Glycoprotein Antibody‐Associated Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine whether myelin‐sensitive quantitative MRI reveals microstructural abnormalities in normal‐appearing cortex (NACtx) in myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), indicating that conventional MRI underestimates remission residual cortical injury.
Valentina Camera, Agnese Tamanti, Silvia Messina, Nicola Dall'Osto, Teresa Maltempo, Stefano Ziccardi, Matteo Foschi, Maria Grazia Piscaglia, Diana Ferraro, Francesco Crescenzo, Francesca Rossi, Albulena Bajrami, Sabrina Marangoni, Damiano Marastoni, Francesca Benedetta Pizzini, Maria Isabel Leite, Roberta Magliozzi, Patrick Waters, Massimiliano Calabrese, Jacqueline Palace, Ruth Geraldes   +20 more
wiley   +1 more source