Results 131 to 140 of about 2,787,968 (277)

Assessing Volumetric Absorptive Microsampling Coupled with Stable Isotope Dilution Assay and Liquid Chromatography-Tandem Mass Spectrometry as Potential Diagnostic Tool for Whole Blood 5-Methyltetrahydrofolic Acid. [PDF]

Front Nutr, 2017
Kopp M, Rychlik M.
europepmc   +1 more source

Enhanced differentiation between 3‐hydroxyglutaric and 2‐hydroxyglutaric acids facilitates diagnostic testing for glutaric aciduria type 1

JIMD Reports
Glutaric aciduria type 1 (GA1) is an inherited neurometabolic disorder, in which deficiency of glutaryl‐CoA dehydrogenase leads to accumulation of glutaric acid (GA) and 3‐hydroxyglutaric acid (3‐HG).
Denis Cyr, Michel Boutin, Bruno Maranda, Paula J. Waters   +3 more
doaj   +1 more source

Multi‐omics–driven precision medicine

iMeta, EarlyView.
Multi‐omics‐driven precision medicine (MODPM) provides a multiscale, continuously learnable framework that integrates genomics, epigenomics, transcriptomics, proteomics, metabolomics, microbiome profiles, and clinical data. Powered by artificial intelligence and foundation models, MODPM enables cross‐modal representation learning, contextual modeling ...
Huibo Li, Zhe Zhao, Yifan Zhang, Yao Ma, Gaofei Hu, Min Zeng, Zhanqun Yang, Zixuan Zhao, Xin Zhou, Wei Hu, Yuxuan Sun, Meng Su, Jun Li, Matthew Whiteman, Wei Fu, Chao Zhong, Lemin Zheng, Long Chen, Hairong Lv, Rongsheng Zhao, Yi Zhun Zhu   +20 more
wiley   +1 more source

Gut virome orchestrates nitrogen partitioning between the host and microbiome

iMeta, EarlyView.
Under normal protein intake, lytic phages promote bacterial turnover, releasing microbial nitrogen that can be assimilated by the host and thereby revealing phage‐mediated lysis as a potential pathway for host nutrient acquisition. Under protein restriction, however, phages shift toward a lysogenic strategy, reducing bacterial death and microbial ...
Shujie Xu, Xianglin Fei, Fengqing Lin, Wenzi Wu, Jiachen Zhuang, Qiufen Mo, Xiuan Zhan, Aikun Fu   +7 more
wiley   +1 more source

Short‐Term 6PPD‐Q Exposure alters Tight‐Junction‐Related Gene Expression Without Acute Lethality in Japanese Medaka Oryzias latipes

Journal of Applied Toxicology, EarlyView.
ABSTRACT 6PPD‐quinone (6PPD‐Q), a transformation product of the tire antioxidant 6PPD, causes acute mortality in several salmonid species, but its toxicity varies markedly among fish species. Disruption of vascular‐barrier integrity and inflammatory signaling has been proposed as a key mechanism of 6PPD‐Q toxicity.
Kyoshiro Hiki
wiley   +1 more source

Corticosterone and Mitochondrial Efficiency Are Associated With Changes in DNA Oxidative Damage During an Acute Stress Response in Leach's Storm‐Petrels (Hydrobates leucorhous)

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, EarlyView.
ABSTRACT The ability of organisms to effectively respond to challenges is critical for survival. We investigated how an acute stressor affected corticosterone, mitochondrial function, and DNA oxidative damage in a wild population of Leach's storm‐petrels (Hydrobates leucorhous).
Kayla E. Lichtner, Jack K. Dziubek, Nicole A. Joseph, Sarah E. Chapman, Tori J. Chace, Dongxiao Sun, Zachary T. Bitzer, Antoine Stier, Robert A. Mauck, Patricia L. Jones, Mark F. Haussmann   +10 more
wiley   +1 more source

Intra‐Plant Nitrogen Isotope Fractionation in Maize

Journal of Plant Nutrition and Soil Science, EarlyView.
ABSTRACT Background and aim The natural abundance of nitrogen isotopes (δ15N) provides a powerful integrative tracer of nitrogen uptake and assimilation in plants, yet the internal partitioning of δ15N among plant tissues remains insufficiently understood.
Priscillia Semaoune, Joëlle Templier, Sylvie Derenne, R. Dave Evans, Mathieu Sebilo   +4 more
wiley   +1 more source

Perspectives of High‐Resolution Mass Spectrometry in Soil Science

Journal of Plant Nutrition and Soil Science, EarlyView.
ABSTRACT Soil biogeochemical research requires specific, sensitive, and accurate methods to identify and quantify organic molecules in order to trace biochemical processes and assess element cycling in complex, heterogenous systems. High‐resolution mass spectrometry (HRMS) has evolved into a transformative tool for unraveling the complex chemical ...
Bruno Glaser, Tobias Bromm, Klaus Kaiser, Arthur Gross, Carsten Simon, Snežana Maletić, Ines Mulder, Oliver J. Lechtenfeld, Sören Thiele‐Bruhn, Ivy Notterpek, Callum Banfield, Michaela A. Dippold   +11 more
wiley   +1 more source

Milankovitch Cyclicity and Stable Isotope Calibration in the Paleogene (invited)

, 2003
Significant progress has been made over the last decade in the extension of astronomically calibrated geological time scales for the Neogene (Hilgen et al., 1999, Shackleton et al., 1999).
Pälike, H., Shackleton, N.J.
core   +1 more source

Ngarrawa (mound spring) sediments as archives of Holocene environmental change in arid central Australia: Insights from Itrax XRF scanning

Journal of Quaternary Science, EarlyView.
ABSTRACT Central Australia's ngarrawa, or ‘mound springs’, are unique hydrological systems that serve as some of the only near‐permanent sources of water and continuous sediment deposition in Australia's arid interior. As such, they hold significant potential as palaeo‐climate and ‐environmental archives in a region where many aspects of past climate ...
Fletcher C. Nixon, Jonathan J. Tyler, Patricia S. Gadd, Quan Hua   +3 more
wiley   +1 more source