Results 171 to 180 of about 15,919 (247)

Stretch strain shifts optic nerve head astrocyte metabolism to enrich α-ketoglutarate and the pentose phosphate pathway. [PDF]

Sci Rep
Suwannasual U, Smart KR, Young O, Suh EH, Golden TD, Inman DM.   +5 more
europepmc   +1 more source

Quantitation of Cirtuvivint (SM08502) in Human Plasma by LC–MS/MS

Biomedical Chromatography, Volume 40, Issue 10, October 2026.
ABSTRACT CDC‐like kinases (CLK) and dual‐specificity tyrosine‐regulated kinases (DYRK) are protein kinases involved in various cellular functions, mRNA splicing, and DNA damage repair. CLK/DYRK kinases have been implicated in many disorders such as diabetes, neurodegenerative diseases, and cancer.
Julianne L. Holleran, Joshua J. Deppas, Ye Feng, Michael J. Hochman, Evan C. Chen, Maximilian Stahl, Steven D. Gore, Timothy W. Synold, Jan H. Beumer, Raman Venkataramanan, Robert A. Parise   +10 more
wiley   +1 more source

A sensitive liquid chromatography-tandem mass spectrometry analytical method of steroid hormones in small blubber samples from four whale species. [PDF]

Conserv Physiol
Dulgheriu D, Andvik C, Jourdain E, Borgå K, Ruus A, Haug T, Karoliussen R, Lyche JL, Horsberg TE.   +8 more
europepmc   +1 more source

Resolution and Quantitation of Ribonucleosides and Deoxyribonucleosides in Digested Genomic DNA by UHPLC–MS/MS

Biomedical Chromatography, Volume 40, Issue 10, October 2026.
ABSTRACT Deoxyuridine (dUrd) is often misincorporated into genomic DNA in cancer patients receiving antimetabolite chemotherapy. This activates base excision repair and recruits ataxia telangiectasia‐mutated and Rad3‐related (ATR), which coordinates DNA repair with nucleotide metabolism by facilitating ribonucleotide reductase (RNR) activity ...
Joshua J. Deppas, Reyna Jones, Robert A. Parise, Pinakin Pandya, Christopher J. Bakkenist, Jan H. Beumer   +5 more
wiley   +1 more source

Human cells for human proteins: Isotope labeling in mammalian cells in suspension for functional NMR studies. [PDF]

Protein Sci
Rößler P, Ruckstuhl MM, Löbbert A, Stühlinger T, Franchini LR, Tsai CJ, Lichtenecker R, Shrestha B, Rüdisser SH, Konrat R, Schertler GFX, Gossert AD.   +11 more
europepmc   +1 more source

The Exceptions to the Central Dogma of Biology—Bending the Rules and Extending the Scope

Natural Sciences, Volume 6, Issue 4, October 2026.
ABSTRACT The central dogma is an organizing framework for how information flows in biological systems. First presented in 1957 by Francis Crick in his talk “On Protein Synthesis” as a fundamental hypothesis of how information is transferred from DNA to proteins but not out of proteins, it is now introduced in cell biology textbooks as three sequential ...
Anat Ben‐Zvi
wiley   +1 more source

Transitioning from Laboratory-Developed Tests to a Single Commercial Reagent Kit in a National Newborn Screening Program: Impact on Analytical Performance and Harmonization. [PDF]

Int J Neonatal Screen
Carling RS, Barclay ZJ, Ward SC, Appleton M, Barski R, Benn H, Chambers K, Coakley P, Kemp H, Crabbe N, Dowden S, Greenfield T, Hogg SL, Hussein S, Marr R, Parkes O, Powell D, Ramgoolam T, Ssali J, Taj N, Wright K, Wu THY, Bonham JR.   +22 more
europepmc   +1 more source

Cryogen‐Aided Chromatographic Purification of Millimole Quantities of Methane for Spectroscopic Clumped Isotope Analysis

Rapid Communications in Mass Spectrometry, Volume 40, Issue 18, 30 September 2026.
ABSTRACT Rationale Quantum cascade laser absorption spectroscopy (QCLAS) is a fast and reliable method for analyzing the bulk (𝛿13C‐CH4, 𝛿D‐CH4) and clumped isotopic (∆13CH3D and ∆12CH2D2) composition of methane. However, precise measurements of ∆12CH2D2 require 0.5 to 1.8 mmol of purified methane (equivalent to 15 to 40 mL at STP).
Nico Kueter, Jan G. C. Meissner, Naizhong Zhang, Léna Msonnereau, Lukas Emmenegger, Joachim Mohn, Stefano M. Bernasconi   +6 more
wiley   +1 more source

Detection of single-cell enzyme activity by single-time-point stable isotope probing-mass spectrometry. [PDF]

Chem Sci
Wu X, Ma Q, Chen H, Cheng C, Li J, Xu F, Chen Y.   +6 more
europepmc   +1 more source

Solar Fuels Via Methane Valorization: Thermochemical Pathways, Unified Metrics, and Techno‐Economic Perspectives

ENERGY &ENVIRONMENTAL MATERIALS, Volume 9, Issue 5, September 2026.
A first‐of‐its‐kind review benchmarks three solar methane valorization pathways with unified performance metrics for clean fuel production. Meeting global climate targets and sustainable energy demands requires carbon‐neutral fuels and innovative conversion pathways.
Muhammad Abdulmoez, Amjad Othman, Majid Linjawi, Amro Al‐Qutub   +3 more
wiley   +1 more source