Results 181 to 190 of about 30,137 (254)

Effect of carbamazepine on the pharmacokinetics of vepdegestrant, a PROteolysis TArgeting Chimera estrogen receptor degrader, in healthy adults

British Journal of Clinical Pharmacology, EarlyView.
Aim To evaluate the effects of carbamazepine, a strong cytochrome P450 (CYP)3A4 inducer, on the pharmacokinetics and safety of vepdegestrant, a PROteolysis TArgeting Chimera estrogen receptor degrader. Methods This was a phase 1, open‐label, fixed‐sequence, two‐period study in healthy adult participants.
Hechuan Wang, Jennifer A. Winton, Kyle T. Matschke, Alexandre Stouffs, Kimberly C. Lee, Yuanyuan Zhang, Wenlian Qiao, Weiwei Tan   +7 more
wiley   +1 more source

Top-Down Structural Characterization of Native Ubiquitin Combining Solution-Stable Isotope Labeling, Trapped Ion Mobility Spectrometry, and Tandem Electron Capture Dissociation Mass Spectrometry. [PDF]

Anal Chem
Jeanne Dit Fouque K, Fernandez-Rojas M, Roque AE, Fernandez-Lima F.   +3 more
europepmc   +1 more source

Postprandial Metabolic Effects of Fiber Mixes Revealed by in vivo Stable Isotope Labeling in Humans. [PDF]

Metabolites, 2019
Schlicker L, Boers HM, Dudek CA, Zhao G, Barua A, Trezzi JP, Meyer-Hermann M, Jacobs DM, Hiller K.   +8 more
europepmc   +1 more source

Research on synthesis of microwave‐assisted heterocyclic compounds with eco‐friendly solvents and transition metals via C–H activation

Bulletin of the Korean Chemical Society, EarlyView.
This review summarizes microwave‐assisted transition‐metal catalysis for constructing N‐ and O‐heterocycles, highlighting rapid C–H and pre‐activated C–X activation, improved selectivity, and green synthetic efficiency. Abstract Microwave‐assisted organic synthesis provides a rapid and sustainable platform for synthesizing various heterocycles ...
Woo‐Jin Park, Ye Ri Han, Hyejeong Lee
wiley   +1 more source

Ligand architecture and secondary‐sphere effects in a well‐defined cobalt(IV)–oxo complex

Bulletin of the Korean Chemical Society, EarlyView.
A well‐defined cobalt(IV)–oxo complex supported by a neutral tetraazamacrocyclic ligand is generated and fully characterized. The cobalt(IV)–oxo species exhibits electrophilic oxygen‐atom and hydrogen‐atom transfer reactivity, strongly modulated by protonation and secondary coordination sphere effects, providing new insight into structure–reactivity ...
Ying Xing, Mi Sook Seo, Yong‐Min Lee, Wonwoo Nam   +3 more
wiley   +1 more source

Multiplexed proteome analysis with neutron-encoded stable isotope labeling in cells and mice. [PDF]

Nat Protoc, 2018
Overmyer KA, Tyanova S, Hebert AS, Westphall MS, Cox J, Coon JJ.   +5 more
europepmc   +1 more source

Resource Allocation Trade‐Offs and Rewired Mycorrhizal Networks Underlie the Adaptation of Paphiopedilum purpuratum to Ex Situ Conservation

Biological Diversity, EarlyView.
Paphiopedilum purpuratum Mediates Adaptation via a Dual‐Fungal Strategy: Confronting a physiological trade‐off (↑seed set vs. ↓photosynthesis), Paphiopedilum purpuratum restructures its root microbiome. Mycorrhizal fungi stabilize into a resilient core network, whereas non‐mycorrhizal fungi shift to a dynamic beneficial periphery.
Yong Tan, Junxi Liang, Wentao Wang, Jianing Tian, Qifei Yi   +4 more
wiley   +1 more source

Subterranean environments contribute to three‐quarters of classified ecosystem services

Biological Reviews, EarlyView.
ABSTRACT Beneath the Earth's surface lies a network of interconnected caves, voids, and systems of fissures forming in rocks of sedimentary, igneous, or metamorphic origin. Although largely inaccessible to humans, this hidden realm supports and regulates services critical to ecological health and human well‐being.
Stefano Mammola, David Brankovits, Tiziana Di Lorenzo, Isabel R. Amorim, Raluca Ioana Bancila, Adrià Bellvert, Enrico Bernard, Anna Blomberg, Paulo A.V. Borges, Martina Cappelletti, Rodrigo Lopes Ferreira, Rosalina Gabriel, Diana M. P. Galassi, Laura Garzoli, Vasilis Gerovasileiou, Grant C. Hose, Kathryn L. Korbel, Simone Martino, Ana Z Miller, Nataša Mori, Veronica Nanni, Giuseppe Nicolosi, Mattia Saccò, Troy S. Sakihara, Marconi Souza Silva, Anne E. Tamalavage, Maja Zagmajster, Efraín Chávez, Christian Griebler, Pedro Cardoso, Alejandro Martínez   +30 more
wiley   +1 more source

Stable isotope labeling kinetics of neurofilament lightin vitroandin vivo

Leckey CA, Giovannucci TA, Coulton JB, He Y, Sato C, Ghoshal N, Vignarajah T, Jaunmuktane Z, Barthélemy NR, Zetterberg H, Elbert DL, Mills K, Wray S, Bateman RJ, Paterson RW.   +14 more
europepmc   +1 more source

Development and Application of FASA, a Model for Quantifying Fatty Acid Metabolism Using Stable Isotope Labeling. [PDF]

Cell Rep, 2018
Argus JP, Wilks MQ, Zhou QD, Hsieh WY, Khialeeva E, Hoi XP, Bui V, Xu S, Yu AK, Wang ES, Herschman HR, Williams KJ, Bensinger SJ.   +12 more
europepmc   +1 more source