Results 171 to 180 of about 2,093,866 (195)
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Kinetic equivalence of stable-isotope-labeled and unlabeled phenytoin
Clinical Pharmacology and Therapeutics, 1981Stable isotope labeling (SIL) of a drug results in a higher molecular weight than that of the unlabeled drug. SIL tracer doses can be quantitated separately from unlabeled drug by gas chromatography-mass spectrometry (GC-MS) without exposing the patient to radiation. The higher molecular weight of SIL drug could cause a higher energy of activation for (
T R, Browne +4 more
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Stable Isotopes Labeling of Drugs in Pediatric Clinical Pharmacology
Pediatrics, 1999Stable isotope labeling (SIL) still has not been used very much in pediatric and perinatal clinical pharmacology. However, this method has numerous advantages. It allows one to determine the concentration of drugs with great sensitivity, thereby allowing quantification in small amounts of biologic samples.
G, Pons, E, Rey
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Profiling of RNA modifications by multiplexed stable isotope labelling
Chemical Communications, 2014The combination of (15)N/(13)C stable isotope labelling (SIL) and LC-MS/MS revealed a total of 52 modifications in RNA from E. coli and yeast, including 10 previously undescribed modifications. Two modifications, N-ribosylnicotinamide and 2-methylthioadenosine, were newly detected in species hitherto thought not to contain these modifications.
Stefanie Kellner +7 more
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Stable isotope labeling of nanomaterials for biosafety evaluation and drug development
Chinese Chemical Letters, 2022Sheng-Tao Yang +2 more
exaly
Tracer or toxicant: Does stable isotope labeling affect central processes in aquatic food webs?
Aquatic Toxicology, 2023Jochen Zubrod +2 more
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Comparing SILAC- and Stable Isotope Dimethyl-Labeling Approaches for Quantitative Proteomics
Journal of Proteome Research, 2014Martin Golkowski +2 more
exaly
Stable isotope labeling methods for protein NMR spectroscopy
Progress in Nuclear Magnetic Resonance Spectroscopy, 2008Masatsune Kainosho, Shin-Ya Ohki
exaly
General Statistical Framework for Quantitative Proteomics by Stable Isotope Labeling
Journal of Proteome Research, 2014Juan Miguel Redondo +2 more
exaly