Results 71 to 80 of about 2,093,866 (195)

Synthesis of stable isotope–labeled chloroquine and amodiaquine and their metabolites

Journal of Labelled Compounds and Radiopharmaceuticals, 2019
Anti‐malaria drugs chloroquine and amodiaquine and their metabolites were synthesized to incorporate 13C and 15N starting from U‐13C–labeled benzene to give M + 7 isotopomers. Chloroquine and its metabolites were prepared from 7‐chloro‐1,2,3,4‐tetrahydroquinolin‐4‐one through an aryl substitution with the corresponding amines; and the amodiaquine and ...
Ruilian Wu, Robert F. Williams, L.A. “Pete” Silks, Jurgen G. Schmidt   +3 more
openaire   +3 more sources

Organic produce and production system conformity assessments : eggs and isotope analysis [PDF]

, 2008
Eggs were analysed for stable isotope composition, as a measure for organic produce ...
van Ruth, S.M., Ruth, S.M., van, Hoogenboom, L.A.P.   +2 more
core  

Diel variations in the carbon isotope composition of respired CO(2) and associated carbon sources: a review of dynamics and mechanisms [PDF]

, 2011
Werner C, Gessler A. Diel variations in the carbon isotope composition of respired CO(2) and associated carbon sources: a review of dynamics and mechanisms. Biogeosciences.
Werner, Christiane ; https://orcid.org/, Geßler, Arthur, C. Werner, Gessler, A., A. Gessler, Werner, Christiane   +5 more
core   +2 more sources

Multi-Spectroscopic Analysis of Seed Quality and 13C-Stable-Iotopologue Monitoring in Initial Growth Metabolism of Jatropha curcas L.

Metabolites, 2014
In the present study, we applied nuclear magnetic resonance (NMR), as well as near-infrared (NIR) spectroscopy, to Jatropha curcas to fulfill two objectives: (1) to qualitatively examine the seeds stored at different conditions, and (2) to monitor the ...
Takanori Komatsu, Risa Ohishi, Amiu Shino, Kinya Akashi, Jun Kikuchi   +4 more
doaj   +1 more source

Stable isotope labelling kinetics of neurofilament light

Brain Communications
Abstract This study provides the first quantification of neurofilament light chain (NfL) kinetics in the human CNS using stable isotope labelling kinetics. NfL is elevated in CSF and blood across a range of traumatic, inflammatory and neurodegenerative diseases of the CNS, and has been increasingly included in clinical trials as a ...
Claire A Leckey, Tatiana A Giovannucci, John B Coulton, Yingxin He, Chihiro Sato, Nupur Ghoshal, Tharini Vignarajah, Zane Jaunmuktane, Nicolas R Barthélemy, Henrik Zetterberg, Donald L Elbert, Kevin Mills, Selina Wray, Randall J Bateman, Ross W Paterson   +14 more
openaire   +2 more sources

Combined stable isotope and gut contents analysis of food webs in plant-dominated, shallow lakes [PDF]

, 2003
1. To determine feeding links between primary producers, invertebrates and fish, stable isotope analyses and gut content analyses of fish were conducted on the components of four shallow, eutrophic to hypertrophic, plant-dominated lakes. 2.
Susan Waldron, J. Iwan Jones, Jones, J.I., Waldron, S.   +3 more
core   +1 more source

13C Tracer Studies of Metabolism in Mouse Tumor Xenografts

Bio-Protocol, 2015
Mice are widely used for human tumor xenograft studies of cancer development and drug efficacy and toxicity. Stable isotope tracing coupled with metabolomic analysis is an emerging approach for assaying metabolic network activity.
Andrew Lane, Jun Yan, Teresa Fan
doaj   +1 more source

The effectiveness of using carbonate isotope measurements of body tissues to infer diet in human evolution: Evidence from wild western chimpanzees (Pan troglodytes verus)* [PDF]

, 2015
Changes in diet throughout hominin evolution have been linked with important evolutionary changes. Stable carbon isotope analysis of inorganic apatite carbonate is the main isotopic method used to reconstruct fossil hominin diets; to test its ...
Boesch, Christophe, Richards, M. ; https://orcid.org/, Hublin, Jean-Jacques, Fahy, Geraldine, Fahy, G. ; https://orcid.org/, Richards, Michael P., Boesch, C. ; https://orcid.org/, Hublin, J. ; https://orcid.org/   +7 more
core   +1 more source

Stable Isotope Tracing Analysis in Cancer Research: Advancements and Challenges in Identifying Dysregulated Cancer Metabolism and Treatment Strategies

Metabolites
Metabolic reprogramming is a hallmark of cancer, driving the development of therapies targeting cancer metabolism. Stable isotope tracing has emerged as a widely adopted tool for monitoring cancer metabolism both in vitro and in vivo.
Dalton Hilovsky, Joshua Hartsell, Jamey D. Young, Xiaojing Liu   +3 more
doaj   +1 more source

Systematic NMR analysis of stable isotope labeled metabolite mixtures in plant and animal systems: coarse grained views of metabolic pathways.

PLoS ONE, 2008
BackgroundMetabolic phenotyping has become an important 'bird's-eye-view' technology which can be applied to higher organisms, such as model plant and animal systems in the post-genomics and proteomics era.
Eisuke Chikayama, Michitaka Suto, Takashi Nishihara, Kazuo Shinozaki, Jun Kikuchi   +4 more
doaj   +1 more source