Results 231 to 240 of about 829,217 (306)

Structure‐Guided Engineering of a Promiscuous O‐Methyltransferase for a SAM Regeneration Biocatalysis Platform of Methylated Pharmaceuticals

open access: yesAdvanced Science, EarlyView.
A substrate promiscuous and regioselective O‐methyltransferase, SmOMT, is functionally and structurally characterized. A double mutant, SmOMTE152A/I306A, exhibited enhanced catalytic activity. By coupling this mutant with a mutant halide methyltransferase, AtHMTV140T, for SAM regeneration, a superior artificial fusion enzyme, AtHMTV140T‐L95‐SmOMTE152A ...
Xiran Xiong   +11 more
wiley   +1 more source

Family interventions in dementia mental health environments (FIND ME): a mixed-methods protocol. [PDF]

open access: yesBMJ Open
Wolverson E   +10 more
europepmc   +1 more source

Gamified Simulation for Onboarding Health Care Teams in Emergency Care: Development and Preliminary Feasibility Study. [PDF]

open access: yesJMIR Form Res
Gobron S   +7 more
europepmc   +1 more source

Trauma-Informed Principles in Practice: A Mixed-Method Study of Co-Producing Systems Change With People Who Have Experienced Multiple Disadvantage. [PDF]

open access: yesHealth Expect
Stone T   +11 more
europepmc   +1 more source

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