Results 231 to 240 of about 19,434,090 (311)

Steps Toward Vitrification and Banking of Coral Larvae Using Field‐Friendly Cryomesh Technology

open access: yesAdvanced Science, EarlyView.
Cryomesh enables a low‐tech cryopreservation method, adding a valuable option to the coral reef conservation toolkit. The approach reveals how size, toxicity, and developmental stage govern larval survival, while modeling links cooling and rewarming rates to a theoretical upper volume limit.
E. Michael Henley   +15 more
wiley   +1 more source

Salivary Citrate Deficiency Defines an Endogenous Dentin Remineralization Failure State Through Glandular MT1/2‐Zn2+‐ACO2 Dysregulation

open access: yesAdvanced Science, EarlyView.
Salivary citrate deficiency in early‐stage Sjögren's syndrome accompanies impaired dentin remineralization despite preserved salivary flow and mineral availability. Matched‐ion experiments reveal disrupted mineral organization and reduced dentin recovery at disease‐associated citrate levels.
Ran You   +8 more
wiley   +1 more source

CKMT1 Counteracts VDAC1 Oligomerization‐Induced Neuronal Pyroptosis Through Steric Hindrance in Ischemic Stroke

open access: yesAdvanced Science, EarlyView.
CKMT1 inhibits VDAC1 oligomerization via a dual‐region mechanism: its NTD interacts with the VDAC1 C‐terminal domain, while residues 1–39 sterically hinder dimerization, thereby reducing mtDNA leakage and AIM2 inflammasome activation, suppressing neuronal pyroptosis and protecting against cerebral ischemic injury. ABSTRACT Ischemic stroke is one of the
Xiaoyu Wang   +17 more
wiley   +1 more source

Bacillus Licheniformis‐Induced Cognitive Decline in Mice Linking Gut Microbiota Dysbiosis, Metabolic Perturbations, and Hippocampal Neuroinflammation

open access: yesAdvanced Science, EarlyView.
Chronic oral administration of specific probiotic strains triggers gut microbiota dysbiosis and systemic metabolic perturbations in mice. Multi‐omics profiling reveals subsequent hippocampal glial remodeling and neuroinflammation, which are linked to cognitive impairment.
Yibin Lin   +15 more
wiley   +1 more source

Roles of Interstitial Albumin in the Subcutaneous Delivery of Therapeutic Peptides

open access: yesAdvanced Science, EarlyView.
A biomimetic extracellular matrix hydrogel platform reveals how interstitial albumin regulates peptide pharmacokinetics after subcutaneous administration. Albumin not only binds peptides but also shows a unique affinity for glycosaminoglycans, thereby reshaping peptide distribution and diffusion.
David Juriga   +7 more
wiley   +1 more source

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