Results 31 to 40 of about 17,110 (211)

Supporting Survivor‐Centered Care Through Digital Health Integration

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Survivors of childhood cancer face barriers to receiving guideline‐based, long‐term follow‐up care. Two digital tools, Passport for Care (PFC) and Cancer SurvivorLink (SurvivorLink), address complementary gaps by enabling tailored survivorship care plan (SCP) generation, updating, storage, and sharing.
Jordan G. Marchak   +15 more
wiley   +1 more source

Collaborative Semantic Annotation Tooling (CoAT) to Improve Efficiency and Plug-and-Play Semantic Interoperability in the Secondary Use of Medical Data: Concept, Implementation, and First Cross-Institutional Experiences

open access: yesApplied Sciences
The cross-institutional secondary use of medical data benefits from structured semantic annotation, which ideally enables the matching and merging of semantically related data items from different sources and sites.
Thomas Wiktorin   +7 more
doaj   +1 more source

Therapeutic Apheresis in Nigeria: A Multi‐Center Summary of Abstracts From the Inaugural Nigerian Society for Apheresis Scientific Meeting

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Therapeutic apheresis (TA) is an established treatment modality for hematologic, neurologic, and immunologic disorders, yet access remains severely limited in sub‐Saharan Africa. Donor apheresis, including platelet apheresis collection from healthy donors, represents an important complementary modality supporting blood product ...
Nosa Bazuaye   +33 more
wiley   +1 more source

Integrated transcriptomic and metabolomic analysis of resistant and susceptible Nicotiana tabacum L. reveals the mechanisms of selenium-induced disease resistance to Phytophthora nicotianae

open access: yesFrontiers in Plant Science
Tobacco black shank, a destructive soil-borne disease caused by Phytophthora nicotianae, severely impacts tobacco production. Selenium (Se) is a beneficial trace element known to enhance plant stress resistance.
Kai Zhang   +10 more
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata   +10 more
wiley   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

open access: yesFEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn   +4 more
wiley   +1 more source

Prediction of Structural Response for HSSCC Deep Beams Implementing a Machine Learning Approach

open access: yesInternational Journal of Coastal and Offshore Engineering, 2018
High Strength Concrete (HSC) is a complex type of concrete, that meets the combination of performance and uniformity at the same time. This paper demonstrates the use of artificial neural networks (ANN) to predict the deflection of high strength ...
Mohammad Mohammadhassani   +3 more
doaj  

Kajian pengukuran performa kota hijau kota metropolitan di Pulau Jawa (studi kasus: Jabodetabek, Kedungsepur, dan Gerbangkertasusila)

open access: yesRegion: Jurnal Pembangunan Wilayah dan Perencanaan Partisipatif
Pendekatan Green City Conceptual Framework (IHS-GCCF) dan Green City Performance Index (GCPI) berbasis pada efisiensi energi dan digunakan untuk masukan pengambilan kebijakan oleh pemangku kepentingan dalam pengembangan metropolitan yang lebih ...
Dina Rachmayati
doaj   +1 more source

Teaching with wikis: improving staff development through action research [PDF]

open access: yesResearch in Learning Technology, 2012
This paper reports on the use of action research in a case study involving two iterations of an online workshop implemented at two universities in late 2007 and early 2009 to prepare teaching staff for using wikis for student group work and assessment ...
Robyn Benson   +2 more
doaj   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source

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