Results 91 to 100 of about 564,631 (288)
Social context prevents heat hormetic effects against mutagens during fish development
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere+5 more
wiley +1 more source
High-risk cutaneous squamous cell carcinoma (SCC) is associated with an increased risk of metastases. The role of sentinel lymph node (SLN) biopsy in these patients remains unclear.
Dong Zhao, Kwon Steve, Wu Peter C
doaj +1 more source
ENAS4D: Efficient Multi-stage CNN Architecture Search for Dynamic Inference [PDF]
Dynamic inference is a feasible way to reduce the computational cost of convolutional neural network(CNN), which can dynamically adjust the computation for each input sample. One of the ways to achieve dynamic inference is to use multi-stage neural network, which contains a sub-network with prediction layer at each stage.
arxiv
miRNA‐29 regulates epidermal and mesenchymal functions in skin repair
miRNA‐29 inhibits cell‐to‐cell and cell‐to‐matrix adhesion by silencing mRNA targets. Adhesion is controlled by complex interactions between many types of molecules coded by mRNAs. This is crucial for keeping together the layers of the skin and for regenerating the skin after wounding.
Lalitha Thiagarajan+10 more
wiley +1 more source
Objective: Recently, the characteristic longitudinal distribution pattern of the underlying phosphorylated TDP-43 (pTDP-43) pathology in the behavioral variant of frontotemporal dementia (bvFTD) excluding Pick's disease (PiD) across specific brain ...
Jan Kassubek+13 more
doaj +1 more source
Revised National Pressure Ulcer Advisory Panel Pressure Injury Staging System
Our understanding of pressure injury etiology and development has grown in recent years through research, clinical expertise, and global interdisciplinary expert collaboration. Therefore, the National Pressure Ulcer Advisory Panel (NPUAP) has revised the
L. Edsberg+5 more
semanticscholar +1 more source
Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner+7 more
wiley +1 more source
Background: The prevalence of HIV in specific areas of South Africa and its impact on haematological parameters are largely unknown. Objectives: To (1) describe the prevalence of HIV, (2) stage HIV based on CD4 counts, and (3) determine haematological ...
Andries J. Groenewald+4 more
doaj +1 more source
Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley +1 more source