Results 91 to 100 of about 879,906 (340)

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

To stage, or not to stage

Current Opinion in Neurobiology, 2020
Staging of neurodegenerative diseases is based chiefly on the topographical or anatomical extent of aggregated proteinaceous inclusions, and the density or severity of the lesions in a given region is usually assessed semiquantitatively. Associated phenomena, such as cell loss and synapse loss, are evaluated but not staged.
Kelly, Del Tredici, Heiko, Braak
openaire   +2 more sources

Nodal involvement evaluation in advanced cervical cancer: a single institutional experience [PDF]

, 2013
Purpose: To assess the usefulness of different imaging techniques in the detection of nodal involvement in patients with advanced cervical carcinoma.
Diestro, Maria Dolores, González-Benítez, C., Hernández, A., Salas, P. I., Santiago, J. de, Zapardiel, I.   +5 more
core   +1 more source

Accuracy of five algorithms to diagnose gambiense human African trypanosomiasis. [PDF]

, 2011
Algorithms to diagnose gambiense human African trypanosomiasis (HAT, sleeping sickness) are often complex due to the unsatisfactory sensitivity and/or specificity of available tests, and typically include a screening (serological), confirmation ...
A Cox, A Garcia, B Courtioux, BM de Clare Bronsvoort, C Burri, C Enoe, C Paquet, Daniel Chandramohan, E Magnus, E Magnus, E Magnus, F Chappuis, F Chappuis, F Checchi, F Checchi, F Noireau, F Noireau, Francesco Checchi, François Chappuis, G Duvallet, Gerardo Priotto, J Blum, J Pepin, J Robays, JC Enyaru, JJ Deeks, JM Bafort, Joseph Mathu Ndung'u, JW Bailey, JW Bailey, JW Kyambadde, L Penchenier, L Penchenier, M Balasegaram, M Gastellu Etchegorry, M Kabiri, M Koffi, M Radwanska, MC Henry, MP Barrett, P Cattand, P Lutumba, P Lutumba, P Truc, P Truc, P Truc, PP Simarro, PP Simarro, PT Woo, R Brun, S Becker, S Bisser, S Molisho, T Ancelle, T Miezan, TW Miezan, TW Miezan, Unni Karunakara, V Jamonneau, V Jamonneau, V Jamonneau, V Lejon, V Lejon, V Lejon, WH Lumsden, WH Lumsden, WL Deville, WO Inojosa   +67 more
core   +6 more sources

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Pathological, immunological and molecular epidemiological analysis of lumpy skin disease virus in Indian cattle during a high-mortality epidemic

Veterinary Quarterly
Lumpy skin disease (LSD) is an economically significant, emerging viral disease of Cattle and Buffaloes. This study aimed to investigate the causes of high mortality in a recent LSD epidemic in India. We examined 1618 animals across seventy outbreaks and
Gundallhalli Bayyappa Manjunathareddy, Mani Saminathan, Lalasangi Sanjeevakumar, Sugana Rao, Murali Dinesh, Kuldeep Dhama, Karam Pal Singh, Bhupendra Nath Tripathi   +7 more
doaj   +1 more source

Time-Staging Enhancement of Hybrid System Falsification

, 2018
Optimization-based falsification employs stochastic optimization algorithms to search for error input of hybrid systems. In this paper we introduce a simple idea to enhance falsification, namely time staging, that allows the time-causal structure of time-
Ernst, Gidon, Hasuo, Ichiro, Sedwards, Sean, Zhang, Zhenya   +3 more
core  

Multimodal Magnetic Resonance and Near-Infrared-Fluorescent Imaging of Intraperitoneal Ovarian Cancer Using a Dual-Mode-Dual-Gadolinium Liposomal Contrast Agent. [PDF]

, 2016
The degree of tumor removal at surgery is a major factor in predicting outcome for ovarian cancer. A single multimodality agent that can be used with magnetic resonance (MR) for staging and pre-surgical planning, and with optical imaging to aid surgical ...
Annapragada, A, Anvari, B, Bankson, J, Bhavane, R, Kundra, V, Ravoori, MK, Singh, S, Sood, AK   +7 more
core   +2 more sources

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source