Results 71 to 80 of about 359,491 (304)

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Cross-labeling MPs from different cell types: non-specific labeling.

, 2015
Double staining with annexin-V and specific markers was applied to four MP types (B-lymphocytes, T-lymphocytes, monocytes and NK-cells). Isotypes were used as negative controls (open line) and the tests are presented by filled histogram.
Hugues Duvillier (15585), Basile Stamatopoulos (58107), Michael Van Damme (5663491), David Perez-Morga (104086), Nathalie Meuleman (58106), Marjorie Vermeesch (739929), Philippe Mineur (361634), Dominique Bron (58110), Emerence Crompot (667274), Karlien Pieters (361632), Laurence Lagneaux (58111)   +10 more
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

ATDC expression correlates directly with index of Ki-67 labeling and expression of cyclinD1 and c-Myc in NSCLC tissues.

, 2013
Immunohistochemical staining of ATDC (A and B), cyclin D1 (C and D), c-Myc (E and F) and Ki67 (G and H) in NSCLC specimens. A, C, E and G indicate a representative case with positive ATDC demonstrating a high level of cyclin D1 and c-Myc, a high labeling
En-Di Wang (420784), Paulie Papavassiliou (420783), Qian-Ze Dong (420781), Quan-Zhe Cui (420782), Zhong-Ping Tang (420780), En-Hua Wang (420785)   +5 more
core   +1 more source

The application of special staining in neuropathological diagnosis

Chinese Journal of Contemporary Neurology and Neurosurgery, 2014
Special staining plays an important role in the clinical neuropathological diagnosis. Some special staining is used to distinguish the specific structure of neuron, such as Nissl staining for Nissl body.
Yong-juan FU, Yue-shan PIAO, De-hong LU
doaj  

Capillary blood as an alternative specimen for enumeration of percentages of lymphocyte subsets

BMC Research Notes, 2019
Objective Capillary blood has been increasingly used in point-of-care setting for clinical monitoring in immunology and infectious diseases. We explored whether percentages of lymphocyte subsets (T-cells; CD3+, helper T-cells; CD4+, cytotoxic T-cells ...
Supanart Srisala, Nutkridta Pongsakul, Thiantip Sahakijpicharn, Suradej Hongeng, Somchai Chutipongtanate, Nopporn Apiwattanakul   +5 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

The application of different staining methods in the morphological observation of non-decalcified bone tissue sections containing implants [PDF]

精准医学杂志
Objective To investigate the application and advantages of different staining methods in the morphological observation of non-decalcified bone tissue sections containing implants.
XU Qian, ZHANG Fan, ZHANG Liguo
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source