Results 141 to 150 of about 7,349,903 (259)
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Evaluation of balance measurement uncertainty based on standard error of calibration coefficients
Kongqi donglixue xuebaoThe measurement uncertainty of strain gauge balance is one of the important sources of uncertainty in aircraft wind tunnel test data. The conventional methodology obtains the balance calibration formula through the comprehensive loading residual method ...
Chao Wang +4 more
doaj +1 more source
Comparison of small-sample standard-error corrections for generalised estimating equations in stepped wedge cluster randomised trials with a binary outcome: A simulation study. [PDF]
Stat Methods Med Res, 2021 Thompson JA +4 more
europepmc +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Continuity Correction and Standard Error Calculation for Testing in Proportional Hazards Models
StatsStandard asymptotic inference for proportional hazards models is conventionally performed by calculating a standard error for the estimate and comparing the estimate divided by the standard error to a standard normal distribution.
Daniel Baumgartner, John E. Kolassa
doaj +1 more source
Minutes of the Standard Club, 1922-1923
, 1922 This volume contains the minutes of the Standard Club women's organization of Dallas, Texas from October 1922 through April 1923.
Standard Club of Dallas
core
Standard error of the log of relative risk (CIHD)
, 2018 Standard error of the log of relative risk ...
KOK YEW NGEW (5206454)
core +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source